In vivo sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. in Swiss Albino mice
-
Md. Jakaria
,
Chayan Dhar Clinton
Abstract
Background:
The superior genus Jacquemontia belongs to Convolvulaceae, with around 120 species, and is also considered taxonomically difficult. The aim of this experiment was to assess the sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f.
Methods:
The sedative and hypnotic activities were evaluated by hole-cross, open field, hole-board, elevated plus maze (EPM), and thiopental sodium-induced sleeping time determination tests in mice at doses of 200 and 400 mg/kg.
Results:
In this investigation, we found that methanol extract of Jacquemontia paniculata (MEJP) produced a significant dose-dependent inhibition of spontaneous activity of mice both in hole-cross and open field tests. In addition, it also decreased the number of head dips in hole-board test. In the case of EPM test, this crude extract induced an anxiogenic-like effect rather than anxiolytic effect in mice. Moreover, MEJP significantly decreased the induction time to sleep and prolonged the duration of sleeping, induced by thiopental sodium.
Conclusions:
To conclude, these results suggest that the MEJP leaves possess potent sedative and hypnotic activities, which supported its therapeutic use for sleep disorders like insomnia.
Acknowledgments
The authors thank the authorities of the Department of Pharmacy, International Islamic University Chittagong for providing valuable laboratory facilities.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. MJ, CDC, MI, MBT, and MSI designed and conducted the experiments under the supervision of SBU. MJ, SMT, and SBU wrote the manuscript and analyzed the data. MJ also edited and drafted the manuscript. All authors read and approved the final manuscript.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Antidepressant and anxiolytic-like, sedation and hypnosis
- Behavior and Neuroprotection
- Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats
- Neuropharmacological evaluation of a novel 5-HT3 receptor antagonist (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl) methanone (6g) on lipopolysaccharide-induced anxiety models in mice
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- In vivo sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. in Swiss Albino mice
- Reproduction
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- Cardiovascular-Pulmonary Interactions
- Meteorological parameters and pollutants on asthma exacerbation in Bangalore, India – an ecological retrospective time-series study
- Oxidative Stress
- Antioxidant and acetylcholinesterase inhibitory activities of leaf extract and fractions of Albizia adianthifolia (Schumach) W.F. Wright
- Oxidative stress, histopathological and electron microscopic alterations induced by dimethylnitrosamine in renal male mice and the protective effect of α-lipoic acid
- Effects of altered thyroid states on oxidative stress parameters in rats
- Metabolism
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- Inflammation
- Investigation of antinociceptive activity of methanolic extract of Persicaria orientalis leaves in rodents
- Infection
- Antiplasmodial activity of the ethanolic root bark extract of Icacina senegalensis in mice infected by Plasmodium berghei
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Articles in the same Issue
- Frontmatter
- Editorial
- Antidepressant and anxiolytic-like, sedation and hypnosis
- Behavior and Neuroprotection
- Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats
- Neuropharmacological evaluation of a novel 5-HT3 receptor antagonist (4-benzylpiperazin-1-yl)(3-methoxyquinoxalin-2-yl) methanone (6g) on lipopolysaccharide-induced anxiety models in mice
- Effect of Salacia reticulata W. and Clitoria ternatea L. on the cognitive and behavioral changes in the streptozotocin-induced young diabetic rats
- In vivo sedative and hypnotic activities of methanol extract from the leaves of Jacquemontia paniculata (Burm.f.) Hallier f. in Swiss Albino mice
- Reproduction
- Bonny light crude oil-induced alteration in levels of testicular stress proteins is accompanied by apoptosis in rats after treatment withdrawal
- Cardiovascular-Pulmonary Interactions
- Meteorological parameters and pollutants on asthma exacerbation in Bangalore, India – an ecological retrospective time-series study
- Oxidative Stress
- Antioxidant and acetylcholinesterase inhibitory activities of leaf extract and fractions of Albizia adianthifolia (Schumach) W.F. Wright
- Oxidative stress, histopathological and electron microscopic alterations induced by dimethylnitrosamine in renal male mice and the protective effect of α-lipoic acid
- Effects of altered thyroid states on oxidative stress parameters in rats
- Metabolism
- The effects of smoking and nicotine ingestion on exercise heat tolerance
- Inflammation
- Investigation of antinociceptive activity of methanolic extract of Persicaria orientalis leaves in rodents
- Infection
- Antiplasmodial activity of the ethanolic root bark extract of Icacina senegalensis in mice infected by Plasmodium berghei
- Phytotherapy
- Evaluation of cytotoxic, analgesic, antidiarrheal and phytochemical properties of Hygrophila spinosa (T. Anders) whole plant
