Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats
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Omar Farid
Abstract
Background:
Ruta montana (L.) is known as a medicinal plant with many beneficial effects, including those that can be used in the treatment of diabetes. The objective of the study was to investigate the antidiabetic effect of this plant in diabetic rat.
Methods:
This study investigated the effects of an aerial part aqueous extract (APAE) of Ruta montana (L.) (RM) at a dose of 5 mg/kg on blood glucose levels in normal and streptozotocin (STZ)-induced diabetic rats. Histopathological changes were also evaluated in liver and pancreas both in normal and STZ-induced rats. The effect of this aqueous extract on glucose tolerance was demonstrated in normal rats. Furthermore, the relative organ weight (ROW) of liver, kidney, pancreas, and brown adipose tissue were evaluated after 15 days of daily oral administration of the aqueous extract.
Results:
Both single and repeated oral doses of APAE (5 mg/kg) produced significant reductions in the blood glucose levels in normal and STZ-induced rats. Oral glucose tolerance test results showed that, after the administration of 3 g/kg of glucose, RM APAE (5 mg/kg) improved the increase in blood glucose levels in normal rats at the 30th min (p<0.01) and 90th min (p<0.001).
Conclusions:
RM APAE exhibits a potent hypoglycemic effect in normal rats and an antidiabetic effect in STZ-induced rats. This finding supports the use of this plant in traditional Moroccan medicine for diabetes management.
Acknowledgments
This work was supported by the CNRST under Grant No. PPR/2015/35.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved its submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances
- Reproduction
- Sub-chronic indomethacin treatment and its effect on the male reproductive system of albino rats: possible protective role of black tea extract
- The effect of extracellular ATP on rat uterine contraction from different gestational stages and its possible mechanisms of action
- Cardiovascular Function
- Effect of cardiovascular and muscular endurance is not associated with stress fracture incidence in female military recruits: a 12-month follow up study
- Cardiovascular-Pulmonary Interactions
- Comparison of structured and unstructured physical activity training on predicted VO2max and heart rate variability in adolescents – a randomized control trial
- Oxidative Stress
- Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes
- Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model
- Metabolism
- Long-term exposure to a butter-rich diet induces mild-to-moderate steatosis in Chang liver cells and Swiss albino mice models
- Effect of adrenocorticotropic hormone on UCP1 gene expression in brown adipocytes
- Phytotherapy
- Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats
- Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)
Articles in the same Issue
- Frontmatter
- Review
- Isolated heart models for studying cardiac electrophysiology: a historical perspective and recent advances
- Reproduction
- Sub-chronic indomethacin treatment and its effect on the male reproductive system of albino rats: possible protective role of black tea extract
- The effect of extracellular ATP on rat uterine contraction from different gestational stages and its possible mechanisms of action
- Cardiovascular Function
- Effect of cardiovascular and muscular endurance is not associated with stress fracture incidence in female military recruits: a 12-month follow up study
- Cardiovascular-Pulmonary Interactions
- Comparison of structured and unstructured physical activity training on predicted VO2max and heart rate variability in adolescents – a randomized control trial
- Oxidative Stress
- Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes
- Anti-aging effects of M2000 (β-D-mannuronic acid) as a novel immunosuppressive drug on the enzymatic and non-enzymatic oxidative stress parameters in an experimental model
- Metabolism
- Long-term exposure to a butter-rich diet induces mild-to-moderate steatosis in Chang liver cells and Swiss albino mice models
- Effect of adrenocorticotropic hormone on UCP1 gene expression in brown adipocytes
- Phytotherapy
- Antidiabetic effect of Ruta montana L. in streptozotocin-induced diabetic rats
- Ethnopharmacological investigation of the aerial part of Phragmites karka (Poaceae)
