Analgesic, anti-inflammatory, and anti-oxidant activities of Phlogacanthus thyrsiflorus leaves
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Biplab Kumar Das
,
Nusrat Nabila Chowdhury
Abstract
Background: Our present study was carried out to explore the potential role of the methanol extract from the leaves of Phlogocanthus thyrsiflorus (PT) Nees. in central and peripheral analgesic activities using hot plate and acetic acid-induced writhing methods. We also tested the anti-inflammatory effects and anti-oxidant activity using carrageenan-induced paw edema and the DPPH method, respectively.
Methods: Methanol extracts of PT leaves were prepared using 500 g powder in 1.8 L methanol by percolation method, followed by evaporation in a rotary evaporator under controlled temperature and pressure. The crude methanol extract was dried by freeze drier and preserved at 4 °C.
Results: Oral administration of PT significantly (p<0.05) increased the reaction time at 55.73% (250 mg/kg) and 72.81% (500 mg/kg) inhibition (p<0.05) in the hot plate test at 3 h. PT significantly (p<0.05) inhibited 42.17% (250 mg/kg) and 56.63% (500 mg/kg) acetic acid-induced writhing. PT leaves (250 and 500 mg/kg) also significantly (p<0.05) inhibited paw edema 6 h after carrageenan injection. Furthermore, this plant showed significant (p<0.05) free radical-scavenging activity at a dose range of 25–800 μg/mL.
Conclusions: Based on the findings, we can conclude that PT leaf possesses analgesic, anti-inflammatory, and anti-oxidant activities. Preliminary phytochemical study of PT leaves revealed the presence of flavonoids, tannins and triterpens in methanol extract which could be correlated with its observed biological activities.
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©2014 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Review
- Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting
- Genotoxicity and Cytotoxicity
- l-Carnitine is a calcium chelator: a reason for its useful and toxic effects in biological systems
- Cardiovascular Function
- Considering space weather forces interaction on human health: the equilibrium paradigm in clinical cosmobiology – is it equal?
- Oxidative Stress
- Analgesic, anti-inflammatory, and anti-oxidant activities of Phlogacanthus thyrsiflorus leaves
- Metabolism
- Inadvertent use of bevacizumab in pregnant women with diabetes mellitus type 1
- Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study
- Hematological Profile
- Influence of extracellular media’s ionic strength on the osmotic stability of Sahel goat erythrocytes
- Inflammation
- Anti-inflammatory and analgesic effects of methanol extract and fractions of Acalypha wilkesiana leaves
- Phytotherapy
- Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats
- Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats
- The relaxant actions of ethanolic extract of Tridax procumbens (Linn.) on rat corpus cavernosum smooth muscle contraction
Artikel in diesem Heft
- Frontmatter
- Review
- Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting
- Genotoxicity and Cytotoxicity
- l-Carnitine is a calcium chelator: a reason for its useful and toxic effects in biological systems
- Cardiovascular Function
- Considering space weather forces interaction on human health: the equilibrium paradigm in clinical cosmobiology – is it equal?
- Oxidative Stress
- Analgesic, anti-inflammatory, and anti-oxidant activities of Phlogacanthus thyrsiflorus leaves
- Metabolism
- Inadvertent use of bevacizumab in pregnant women with diabetes mellitus type 1
- Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study
- Hematological Profile
- Influence of extracellular media’s ionic strength on the osmotic stability of Sahel goat erythrocytes
- Inflammation
- Anti-inflammatory and analgesic effects of methanol extract and fractions of Acalypha wilkesiana leaves
- Phytotherapy
- Rosmarinic acid inhibits DMH-induced cell proliferation in experimental rats
- Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats
- The relaxant actions of ethanolic extract of Tridax procumbens (Linn.) on rat corpus cavernosum smooth muscle contraction
