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Analgesic, anti-inflammatory and antipyretic effects of Ixora coccinea

  • Md. Syed Ali Adnan , Md. Mamun Al-Amin EMAIL logo , Mir Muhammad Nasir Uddin , M. Shohel , Rajib Bhattacharjee , J.M.A. Hannan and Biplab Kumar Das
Published/Copyright: January 27, 2014

Abstract

Background: The present study was carried out to explore the potential of the ethanol extract of Ixora coccinea L. (IC) leaves as analgesic, anti-inflammatory and antipyretic agents using the hot-plate, acetic acid-induced writhing, carrageenan-induced paw edema and brewer’s yeast-induced pyrexia tests in rodents.

Methods: The extract was prepared by soaking the dried powdered leaves of IC in ethanol for 2 days. The filtrate thus obtained by filtration and evaporation was considered as a stock solution and was used in all experimental models.

Results: Oral administration of IC (250 and 500 mg/kg) significantly (p<0.05) increased the reaction time in the hot-plate test. Ixora coccinea (250 and 500 mg/kg) produced 56.14% and 63.16% inhibition (p<0.05) in acetic acid-induced writhing. It also (250 and 500 mg/kg) produced significant (p<0.05) inhibition of paw edema pronounced at 6 h after carrageenan injection. Intraperitoneal administration of IC (250 and 500 mg/kg) lowered the body temperature in brewer’s yeast-induced hyperthermia.

Conclusions: Based on the findings, it may be concluded that the IC leaves possessed analgesic, anti-inflammatory, and antipyretic activities. Phytochemical constituents of IC leaves such as flavonoids, tannins, and triterpenes in ethanol extract could be correlated with its observed biological activities.


Corresponding author: M.M. Al-Amin, Department of Pharmacy, North South University, Plot 15, Block B, Bashundhara, Dhaka-1229, Bangladesh, Phone: +88-01927077102, Fax: +88-2-8852016, E-mail: ;

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Received: 2013-8-20
Accepted: 2013-12-9
Published Online: 2014-1-27
Published in Print: 2014-11-1

©2014 by De Gruyter

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