Rare cases of disorders of sex development (DSD) in adolescents with female phenotype
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Jenara Kristesashvili
,
Mariam Chipashvili
Abstract
Background: Disorders of sex development (DSD) belong to uncommon pathologies; in addition, there are especially rare forms, such are ovotesticular disorders (OT), Turner syndrome and early malignisation of intraabdominal located gonads in the cases of androgen insensitivity syndrome.
Objective: In this article we present four rare cases of DSD in female phenotype adolescents: two cases of ovotesticular DSD with 46,XX and 46,XY karyotypes; one familial case of androgen insensitivity syndrome (AIS) with early malignancy (19-year-old) of intra-abdominally-located testicle in older siblings, and a case of spontaneous menstruation in a patient with Turner syndrome and mosaic karyotype 45,X/47,XXX. Rare cases of DSD are connected with diagnostic and management difficulties and so description of each such case and collection of data in this field is very important from a scientific, as well as a practical, point of view. Determination of prognosis and adequate management of each individual patient are also essential. Study of this issue is especially sensitive in the case of adolescent patients in order to avoid physiological stress, to reduce health risks and to improve quality of life.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Editorial
- Dean Ornish should receive the Nobel prize in medicine
- Review Articles
- Adolescent suicide in New York City: plenty of room for new research
- Consequences of prenatal substance use
- The need for evidence-based, non-drug medicine
- Teaching medical professionals and trainees about adolescent suicide prevention: five key problems
- Original Articles
- Sexual violence and associated factors among women in HIV discordant and concordant relationships in Uganda
- Educational impact of peer-intervention on the knowledge and attitudes about HIV/AIDS in adolescents in Panama
- Tobacco brand preference among Mexican adolescents
- Spirituality and substance use in a sample of Russian adolescents
- Collaborative evaluation and management of students’ health-related physical fitness: applications of cluster analysis and the classification tree
- Body weight satisfaction among New Zealand adolescents: findings from a national survey
- Prevalence of common mental disorders among Dutch medical students and related use and need of mental health care: a cross-sectional study
- Reaching Jewish ultra-orthodox adolescents: results from a targeted smoking prevention trial
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- Rare cases of disorders of sex development (DSD) in adolescents with female phenotype
