Hemihyperplasia/hemihypertrophy in adolescents: prospective international study

Michael Vaiman; Phillip Shilco; Yulia Roitblat; Lilia Nehuliaieva; Sari Rosenberg; Aidan Leit; Ryan Cleminson; Michael Shterenshis

doi:10.1515/ijamh-2018-0066

Article

Hemihyperplasia/hemihypertrophy in adolescents: prospective international study

Michael Vaiman , Phillip Shilco , Yulia Roitblat , Lilia Nehuliaieva , Sari Rosenberg , Aidan Leit , Ryan Cleminson and Michael Shterenshis

Published/Copyright: January 12, 2019

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From the journal International Journal of Adolescent Medicine and Health Volume 33 Issue 1

Abstract

Aim

The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 to 1:86,000 live births) and further clarification is needed. We hypothesized that a survey of the birth prevalence of IH among newborn infants may underestimate the incidence of IH by overlooking late-onset cases.

Methods

The prospective international multicenter study utilized the two-steps selection tool for an anonymous survey of volunteers of 15–18 years old. The initial step was “three measurements-three questions” screening, or “face-palms-calves survey”. The subsequent step was an in-depth assessment of selected cases to exclude localized, lesional and syndrome-related cases as well as body asymmetry within normative range and to select suspected cases of IH. This step included measurements of various anatomical regions and a subsequent questionnaire. The participants that were selected in a risk group were advised to refer to medical institutions for clinical, genetic and instrumental investigation.

Results

Out of 6000 of selected participants (male, M 3452, female, F 2548), 229 (3.82%) were selected for detailed investigation and 57 (0.95%) were assigned to the risk group. Only 36 of them were actually referred to medical institutions and in two cases the diagnosis of IH was confirmed.

Conclusion

Our survey indicated the prevalence of IH at the age of adolescence as approximately 1:3000. While IH is a hereditary genetic disorder, it may not be detected in newborns and infants and the true prevalence of the disease can be estimated if older age children are screened.

Keywords: adolescents; asymmetric regional; body asymmetry; body overgrowth; hemihyperplasia; hemihypertrophy

Acknowledgments

The authors thank Rachelle Sevitt, Brian Frank, and Alex Lasky for assistance in the research in Israel, Aaron Kavin and Edan Schonberger for assistance in the research in Australia and Jacob Ilani for assistance in the research in the USA.

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Received: 2018-04-02

Accepted: 2018-06-05

Published Online: 2019-01-12

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Articles in the same Issue

https://doi.org/10.1515/ijamh-2018-0066

Keywords for this article

adolescents; asymmetric regional; body asymmetry; body overgrowth; hemihyperplasia; hemihypertrophy