Impaired dynamic thiol/disulfide homeostasis in pubertal gynecomastia
-
Özge Yüce
,
Derya Tepe
Abstract
Background
The aim of the study was to evaluate the dynamic thiol/disulfide homeostasis (TDH) with a new method in patients with pubertal gynecomastia and also to investigate the relationship between sex hormones.
Methods
Thiol/disulfide homeostasis, involving native thiol (SH), disulfide (SS) and total thiol (SS + SH), was evaluated between 20 adolescent boys with gynecomastia in mid-puberty and 50 healthy adolescents, who were matched for age, body mass index (BMI) and pubertal stage. The correlations of total serum testosterone (TT) and estradiol (E2) levels with the oxidative parameters were also determined.
Results
No significant difference was found between the total thiol, native thiol, disulfide/native thiol and disulfide/total thiol ratios of the patient and control groups. The mean disulfide concentrations, disulfide/native thiol and the disulfide/total thiol ratios were statistically significantly higher in the patient group than in the controls. A positive correlation was found between the E2 and native thiol levels, also there was a negative correlation between the E2 and disulfide levels. TT was negatively correlated with both native thiol and disulfide levels. All these did not statistically differ between the patients with unilateral and bilateral gynecomastia.
Conclusions
There was an impaired thiol/disulfide homeostasis in patients with pubertal gynecomastia. According to this result, we can postulate that oxidative stress may be an etiologic factor that contributes to initiation and/or progression of gynecomastia.
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Articles in the same Issue
- Frontmatter
- Original Articles
- Awareness and practices of menstrual hygiene among females of reproductive age in rural Puducherry – a mixed method study
- Many hours of watching medical TV shows is associated with greater medical knowledge
- Spatio-temporal trends in the risk of adolescent pregnancy in Minas Gerais, Brazil, 2000–2015
- Sexual behaviour and its correlates among adolescents in Brunei Darussalam
- The relationship between anxiety and social support in male and female students in high schools in the southeast of Iran
- Cannabis and amphetamine use and socio-ecological (proximal and distal) factors among school-going adolescents in four countries in the Caribbean and four countries in South America
- Gender differences in concussion-related knowledge, attitudes and reporting-behaviours among high school student-athletes
- Determinants of overweight and obesity among urban school-going children and adolescents: a case-control study in Bangladesh
- Addiction to the Internet and mobile phones and its relationship with loneliness in Iranian adolescents
- Prevalence and associated factors for social phobia among school-going adolescents in a rural area of Puducherry, South India
- Self-efficacy of osteoporosis preventive behaviors and its predictors in Iranian adolescents
- Prevalence of pediculosis and its related factors among primary school girls in the north of Iran
- Risk behaviors in adolescence – a study in a Portuguese health unit
- Statistical analysis for the impact of smoking on the behavior and health of Qatari adolescents
- Risk behaviors screening in Thai adolescents with acute and chronic illnesses
- Prenatal and early life origins of adolescence sleep problems: evidence from a birth cohort
- Intake of fruit, vegetables and milk products and correlates among school boys in Saudi Arabia
- Determinants of early marriage among female adolescent in Indonesia
- Social health needs of Iranian male adolescents
- Radiation and its associated health risks: assessment of knowledge and risk perception among adolescents and young adults in Saudi Arabia
- What does social media have to do with health? A case study of Bangkok youths
- Determining the development of syntax in typically-developing Indian adolescents using a syntactic analysis package
- Prevalence of traumatic injuries to the anterior teeth among 3–17-year-old school children of Indore and correlating it with Kuppuswamy SES, occlusal relationship and ascertaining percentage of those seeking the treatment
- Impaired dynamic thiol/disulfide homeostasis in pubertal gynecomastia
- Can upper limb taping or exercises improve hand function, writing speed and self-perception of performance in adolescent school children?
- Hemihyperplasia/hemihypertrophy in adolescents: prospective international study
- Depression in a sample of Tunisian adolescents: prevalence, associated factors and comorbidity with anxiety disorders
- Predictors of sexual function in pregnant Iranian adolescents
- Spiritual belief and its link with potentially addictive behaviors in a youth sample in Switzerland
- Short Communications
- Violence depicted in advertisements on LinkNYC kiosks in Manhattan, New York City
- Major food groups contributing to sodium intake in school-attending adolescents
