Abstract
Aortic dilatation and aortic dissection are increasingly recognised in patients with Turner syndrome (TS). Risk factors for aortic dissection include aortic dilatation, bicuspid aortic valves, coarctation of aorta and pregnancy. The risk of death due to aortic dissection in pregnancy in TS is 2%, which is approximately 100 times higher than the general population, as maternal mortality is extremely low. Ongoing cardiovascular monitoring is recommended, although there remain several unanswered questions in relation to cardiovascular imaging especially the choice of modality for detection of vascular, valvular abnormalities and measurements of aortic dimensions. Due to the relative short stature of patients with TS, aortic dimensions need to be defined by aortic measurements adjusted for body surface area, known as aortic sized index (ASI). The relationship of ASI and other risk factors with aortic dissection is only beginning to be clarified. Clinical management and monitoring of such patients should be delivered by a group of clinicians familiar with the issues unique to TS patients in a multidisciplinary fashion. All clinicians including the non-specialists need to have a low threshold of suspecting aortic dissection in these adolescents and young adults. This up to date review, including a summary of all 122 published cases of TS patients with aortic dissection, aims to provide a summary of recent publications on characteristics of aortic dissection and aortic dilatation in TS to highlight gaps in knowledge and propose possible clinical monitoring pathway of cardiovascular health in children and adults with TS. Cardiovascular assessment and risk counselling is especially crucial during the period of transition of adolescents with TS, although life long monitoring by expert cognizant to the issues specific in TS is essential.
Acknowledgements
The Murdoch Childrens Research Institute is supported by the Victorian Government’s Operational Infrastructure Support Program. The Heart Research Group is supported by RCH 1000, The Royal Children’s Hospital Foundation.
Conflict of interest statement
All the authors have no conflicts of interest to declare in relation to this clinical review.
References
1. Stochholm K, Juul S, Juel K, Naeraa RW, Gravholt CH. Prevalence, incidence, diagnostic delay, and mortality in Turner syndrome. J Clin Endocrinol Metab 2006;91:3897–902.10.1210/jc.2006-0558Search in Google Scholar
2. Bondy CA. Aortic dissection in Turner syndrome. Curr Opin Card 2008;23:519–26.10.1097/HCO.0b013e3283129b89Search in Google Scholar
3. Bondy CA. Heart disease in Turner syndrome. Minerva Endocrinologica 2007;32:245–61.Search in Google Scholar
4. Bondy CA. Congenital cardiovascular disease in Turner syndrome. Congenit 2008;3:2–15.10.1111/j.1747-0803.2007.00163.xSearch in Google Scholar
5. Mortensen KH, Andersen NH, Gravholt CH. Cardiovascular phenotype in Turner syndrome—integrating cardiology, genetics, and endocrinology. Endocr Rev 2012;33:677–714.10.1210/er.2011-1059Search in Google Scholar
6. Gotzsche CO, Krag-Olsen B, Nielsen J, Sorensen KE, Kristensen BO. Prevalence of cardiovascular malformations and association with karyotypes in Turner’s syndrome. Arch Dis Child 1994;71:433–6.10.1136/adc.71.5.433Search in Google Scholar
7. Ho VB, Bakalov VK, Cooley M, Van PL, Hood MN, et al. Major vascular anomalies in Turner syndrome: prevalence and magnetic resonance angiographic features. Circulation 2004;110:1694–700.10.1161/01.CIR.0000142290.35842.B0Search in Google Scholar
8. Mazzanti L, Cacciari E. Congenital heart disease in patients with Turner’s syndrome. Italian Study Group for Turner Syndrome (ISGTS). J Pediatr 1998;133:688–92.10.1016/S0022-3476(98)70119-2Search in Google Scholar
9. Prandstraller D, Mazzanti L, Picchio FM, Magnani C, Bergamaschi R, et al. Turner’s syndrome: cardiologic profile according to the different chromosomal patterns and long-term clinical follow-Up of 136 nonpreselected patients. Pediatr Cardiol 1999;20:108–12.10.1007/s002469900416Search in Google Scholar PubMed
10. Hjerrild BE, Mortensen KH, Sorensen KE, Pedersen EM, Andersen NH, et al. Thoracic aortopathy in Turner syndrome and the influence of bicuspid aortic valves and blood pressure: a CMR study. J Cardiovasc Magn Reson 2010;12:12.10.1186/1532-429X-12-12Search in Google Scholar PubMed PubMed Central
11. Sachdev V, Matura LA, Sidenko S, Ho VB, Arai AE, et al. Aortic valve disease in Turner syndrome. J Am Coll Cardiol 2008;51:1904–9.10.1016/j.jacc.2008.02.035Search in Google Scholar PubMed
12. Volkl TMK, Degenhardt K, Koch A, Simm D, Dorr HG, et al. Cardiovascular anomalies in children and young adults with Ullrich-Turner syndrome the Erlangen experience. Clin Cardiol 2005;28:88–92.10.1002/clc.4960280209Search in Google Scholar
13. Olivieri LJ, Baba RY, Arai AE, Bandettini WP, Rosing DR, et al. Spectrum of aortic valve abnormalities associated with aortic dilation across age groups in Turner syndrome. Circ Cardiovasc Imaging 2013;6:1018–23.10.1161/CIRCIMAGING.113.000526Search in Google Scholar
14. Kim HK, Gottliebson W, Hor K, Backeljauw P, Gutmark-Little I, et al. Cardiovascular anomalies in Turner syndrome: spectrum, prevalence, and cardiac MRI findings in a pediatric and young adult population. AJR Am J Roentgenol 2011;196:454–60.10.2214/AJR.10.4973Search in Google Scholar
15. Price WH, Willey RF. Partial anomalous pulmonary venous drainage in two patients with Turner’s syndrome. J Med Genet 1980;17:133–4.10.1136/jmg.17.2.133Search in Google Scholar
16. Fang J, Dagenais SL, Erickson RP, Arlt MF, Glynn MW, et al. Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. Am J Hum Genet 2000;67:1382–8.10.1086/316915Search in Google Scholar
17. Bondy C, Bakalov VK, Cheng C, Olivieri L, Rosing DR, et al. Bicuspid aortic valve and aortic coarctation are linked to deletion of the X chromosome short arm in Turner syndrome. J Med Genet 2013;50:662–5.10.1136/jmedgenet-2013-101720Search in Google Scholar
18. Kim J, Park J, Choi S, Chi S-G, Mowbray AL, et al. X-linked inhibitor of apoptosis protein is an important regulator of vascular endothelial growth factor-dependent bovine aortic endothelial cell survival. Circ Res 2008;102:896–904.10.1161/CIRCRESAHA.107.163667Search in Google Scholar
19. Gravholt CH, Landin-Wilhelmsen K, Stochholm K, Hjerrild BE, Ledet T, et al. Clinical and epidemiological description of aortic dissection in Turner’s syndrome. Cardiol Young 2006;16:430–6.10.1017/S1047951106000928Search in Google Scholar
20. Gopal AS, Arora NS, Vardanian S, Messineo FC. Utility of transesophageal echocardiography for the characterization of cardiovascular anomalies associated with Turner’s syndrome. J Am Soc Echocardiogr 2001;14:60–2.10.1067/mje.2001.109197Search in Google Scholar
21. Rubin K. Aortic dissection and rupture in Turner syndrome. J Pediatr 1993;122:670.10.1016/S0022-3476(05)83571-1Search in Google Scholar
22. Price WH, Wilson J. Dissection of the aorta in Turner’s syndrome. J Med Genet 1983;20:61–3.10.1136/jmg.20.1.61Search in Google Scholar
23. Sybert VP. Cardiovascular malformations and complications in Turner syndrome. Pediatrics 1998;101:E11.10.1542/peds.101.1.e11Search in Google Scholar
24. Price WH, Clayton JF, Collyer S, De Mey R, Wilson J. Mortality ratios, life expectancy, and causes of death in patients with Turner’s syndrome. J Epidemiol Community Health 1986;40: 97–102.10.1136/jech.40.2.97Search in Google Scholar
25. Hirose H, Amano A, Takahashi A, Nagano N, Kohmoto T. Ruptured aortic dissecting aneurysm in Turner’s syndrome: a case report and review of literature. Ann Thorac Cardiovasc Surg 2000;6:275–80.Search in Google Scholar
26. Chlumsky J, Kolbel F, Buresova M, Svab P, Krutilkova V, et al. [A dissecting aortic aneurysm in a female patient with Turner syndrome]. Vnitr Lek 2000;46:34–6.Search in Google Scholar
27. Meunier JP, Jazayeri S, David M. Acute type A aortic dissection in an adult patient with Turner’s syndrome. Heart 2001;86:546.10.1136/heart.86.5.546Search in Google Scholar
28. Clement CI, Brereton J, Clifton-Bligh P. Aortic dissection in Turner syndrome. Med J Australia 2004;180:584.10.5694/j.1326-5377.2004.tb06097.xSearch in Google Scholar
29. Buheitel G, Singer H, Hofbeck M. [Aortic aneurysms in Ullrich-Turner syndrome]. Klin Padiatr 1996;208:42–5.10.1055/s-2008-1043992Search in Google Scholar
30. Kusaba E, Imada T, Iwakuma A, Nonaka K. [Aortic aneurysm complicated with coarctation of the aorta and Turner syndrome]. Kyobu geka 1995;48:1115–7.Search in Google Scholar
31. Allemann J, Muller G, Legat M. [Rare variant of a Turner-Ullrich syndrome]. Schweiz Med Wochenschr 1982;112:1249–55.Search in Google Scholar
32. Lin AE, Lippe B, Rosenfeld RG. Further delineation of aortic dilation, dissection, and rupture in patients with Turner syndrome. Pediatrics 1998;102:e12.10.1542/peds.102.1.e12Search in Google Scholar
33. Kostich ND, Opitz JM. Ullrich-Turner syndrome associated with cystic medial necrosis of the aorta and great vessels: case report and review of the literature. Am J Med 1965;38:943–50.10.1016/0002-9343(65)90014-8Search in Google Scholar
34. Lippe BM, Kogut MD. Aortic rupture in gonadal dysgenesis. J Pediatr 1972;80:895–6.10.1016/S0022-3476(72)80162-8Search in Google Scholar
35. Weytjens C, Bove T, Van Der Niepen P. Aortic dissection and Turner’s syndrome. J Cardiovasc Surg 2000;41:295–7.Search in Google Scholar
36. Fejzic Z, van Oort A. Fatal dissection of the descending aorta after implantation of a stent in a 19-year-old female with Turner’s syndrome. Cardiol Young 2005;15:529–31.10.1017/S1047951105001447Search in Google Scholar PubMed
37. Bordeleau L, Cwinn A, Turek M, Barron-Klauninger K, Victor G. Aortic dissection and Turner’s syndrome: case report and review of the literature. J Emerg Med 1998;16:593–6.10.1016/S0736-4679(98)00041-9Search in Google Scholar
38. Landin-Wilhelmsen K, Bryman I, Hanson C, Hanson L. Spontaneous pregnancies in a Turner syndrome woman with Y-chromosome mosaicism. J Assist Reprod Genet 2004;21:229–30.10.1023/B:JARG.0000040239.40913.c3Search in Google Scholar
39. Badmanaban B, Mole D, Sarsam MAI. Descending aortic dissection post coarctation repair in a patient with Turner’s syndrome. J Cardiac Surg 2003;18:153–4.10.1046/j.1540-8191.2003.02001.xSearch in Google Scholar
40. Bartlema KA, Hogervorst M, Akkersdijk GJ, Seelen J, Hoogland P, et al. Isolated abdominal aortic dissection in a patient with Turner’s syndrome. Surgery 1995;117:116–7.10.1016/S0039-6060(05)80241-7Search in Google Scholar
41. Nagel TC, Tesch LG. ART and high risk patients. Fertil Steril 1997;68:748–9.Search in Google Scholar
42. Hata J. Ultrastructural and histochemical studies on aortic dissection aneurysm. Myok Kangaku 1986;26:493–8.Search in Google Scholar
43. Asch AJ. Turner’s syndrome occurring with Horner’s syndrome. Seen with coarctation of the aorta and aortic aneurysm. Am J Dis Child 1979;133:827–30.10.1001/archpedi.1979.02130080067013Search in Google Scholar
44. Guerin FGD de Saint-Maur P, Akoun J, Josso N. Dissection aortique et syndrome de Turner. Couer 1974;5:771–5.Search in Google Scholar
45. Imamura M, Aoki H, Eya K, Murakami T, Yasuda K. Balloon angioplasty before Wheat’s operation in a patient with Turner’s syndrome. Cardiovasc Surg 1995;3:70–2.10.1016/0967-2109(95)92908-ZSearch in Google Scholar
46. Ohuchi H, Takasugi H, Ohashi H, Okada Y, Yamada O, et al. Stratification of pediatric heart failure on the basis of neurohormonal and cardiac autonomic nervous activities in patients with congenital heart disease. Circulation 2003;108:2368–76.10.1161/01.CIR.0000101681.27911.FASearch in Google Scholar
47. Goldberg SM, Pizzarello RA, Goldman MA, Padmanabhan VT. Aortic dilatation resulting in chronic aortic regurgitation and complicated by aortic dissection in a patient with Turner’s syndrome. Clin Cardiol 1984;7:233–5.10.1002/clc.4960070408Search in Google Scholar
48. Beauchesne LM, Connolly HM, Ammash NM, Warnes CA. Coarctation of the aorta: outcome of pregnancy. J Am Coll Cardiol 2001;38:1728–33.10.1016/S0735-1097(01)01617-5Search in Google Scholar
49. Shiroma K, Ebine K, Tamura S, Yokomuro M, Suzuki H, et al. A case of Turner’s syndrome associated with partial anomalous pulmonary venous return complicated by dissecting aortic aneurysm and aortic regurgitation. J Cardiovasc Surg 1997; 38:257–9.Search in Google Scholar
50. Apostolopoulos T, Kyriakidis M, Toutouzas P. Endarteritis of the aortic arch in Turner’s syndrome with cystic degeneration of the aorta. Int J Cardiol 1992;35:417–9.10.1016/0167-5273(92)90244-WSearch in Google Scholar
51. Slater DN, Grundman MJ, Mitchell L. Turner’s syndrome associated with bicuspid aortic stenosis and dissecting aortic aneurysm. Postgrad Med J 1982;58:436–8.10.1136/pgmj.58.681.436Search in Google Scholar
52. Ravelo HR, Stephenson LW, Friedman S, Chatten J, Rashkind WJ, et al. Coarctation resection in children with Turner’s syndrome: a note of caution. J Thorac Cardiovasc Surg 1980;80:427–30.10.1016/S0022-5223(19)37770-0Search in Google Scholar
53. Oohara K, Yamazaki T, Sakaguchi K, Nakayama M, Kobayashi A. Acute aortic dissection, aortic insufficiency, and a single coronary artery in a patient with Turner’s syndrome. J Cardiovasc Surg 1995;36:273–5.Search in Google Scholar
54. Kido G, Miyagi A, Shibuya T, Miyagami M, Tsubokawa T, et al. [Turner’s syndrome with pituitary hyperplasia: a case report]. No Shinkei Geka 1994;22:333–8.Search in Google Scholar
55. Akimoto N, Shimizu T, Ishikawa M, Ishimaru S, Furukawa K. The surgical treatment of aortic dissection in a patient with Turner’s syndrome: report of a case. Surgery Today 1994;24:929–32.10.1007/BF01651013Search in Google Scholar
56. Salgado CR. [Turner’s syndrome. Report of a case associated with dissecting aneurysm of the aorta. Review of the literature]. Rev Fac Cienc Med Cordoba 1961;19:193–204.Search in Google Scholar
57. Ota Y, Tsunemoto M, Shimada M, Ishizawa A, Koike K, et al. [Aortic dissection associated with Turner’s syndrome]. Kyobu Geka 1992;45:411–4.Search in Google Scholar
58. Youker JE, Roe BB. Aneurysm of the aortic sinuses and ascending aorta in Turner’s syndrome. Am J Cardiol 1969;23:89–93.10.1016/0002-9149(69)90246-XSearch in Google Scholar
59. Cecchi F, Samoun M, Santoro G, Calamai G. [Chronic dissecting aortic aneurysm and Turner’s syndrome. Apropos of a case]. Arch Mal Coeur Vaiss 1992;85:1043–6.Search in Google Scholar
60. Subramaniam PN. Turner’s syndrome and cardiovascular anomalies: a case report and review of the literature. Am J Med Sci 1989;297:260–2.10.1097/00000441-198904000-00014Search in Google Scholar
61. Anabtawi IN, Ellison RG, Yeh TJ, Hall DP. Dissecting aneurysm of aorta associated with Turner’s syndrome. J Thorac Cardiovasc Surg 1964;47:750–4.10.1016/S0022-5223(19)33503-2Search in Google Scholar
62. Lie JT. Aortic dissection in Turner’s syndrome. Am Heart J 1982;103:1077–80.10.1016/0002-8703(82)90577-4Search in Google Scholar
63. Pollak H, Veit F, Enenkel W. [Presumed “successful” fibrinolysis in unrecognized acute aortic dissection]. Dtsch Med Wochenschr 1992;117:368–71.10.1055/s-2008-1062321Search in Google Scholar PubMed
64. Hochberg Z. Sudden death in Turner’s syndrome. Harefuh 1995;129:285–8.Search in Google Scholar
65. Jeresaty RM, Basu SK, Franco J. Dissecting aneurysm of the aorta in Turner’s syndrome. J Am Med Assoc 1972;222:574–6.10.1001/jama.1972.03210050046010Search in Google Scholar
66. Miller JM, Herrera EL, Puga UC, Torres GS. Sindrome de Turner y aneurisma disecante de la aorta. Arch Inst Cardiol Mex 1974;44:771–5.Search in Google Scholar
67. Carlson M, Airhart N, Lopez L, Silberbach M. Moderate aortic enlargement and bicuspid aortic valve are associated with aortic dissection in Turner syndrome: report of the international turner syndrome aortic dissection registry. Circulation 2012;126:2220–6.10.1161/CIRCULATIONAHA.111.088633Search in Google Scholar PubMed
68. Carlson M, Silberbach M. Dissection of the aorta in Turner syndrome: two cases and review of 85 cases in the literature. J Med Genet 2007;44:745–9.10.1136/jmg.2007.052019Search in Google Scholar PubMed PubMed Central
69. Matura LA, Ho VB, Rosing DR, Bondy CA. Aortic dilatation and dissection in Turner syndrome. Circulation 2007;116:1663–70.10.1161/CIRCULATIONAHA.106.685487Search in Google Scholar PubMed
70. Chevalier N, Letur H, Lelannou D, Ohl J, Cornet D, et al. Materno-fetal cardiovascular complications in Turner syndrome after oocyte donation: insufficient prepregnancy screening and pregnancy follow-up are associated with poor outcome. J Clin Endocrinol Metab 2011;96:E260–7.10.1210/jc.2010-0925Search in Google Scholar PubMed
71. Pleskacova J, Rucklova K, Popelova J, Cerny S, Syrucek M, et al. Aortic dissection and rupture in a 16-year-old girl with Turner syndrome following previous progression of aortic dilation. Eur J Pediatr 2010;169:1283–6.10.1007/s00431-010-1197-4Search in Google Scholar PubMed
72. Mimasaka S, Ohtsu Y, Tsunenari S, Matsukawa A, Hashiyada M, et al. Sudden death of a young woman due to aortic dissection caused by Turner’s syndrome. Pathol Int 2007;57:219–23.10.1111/j.1440-1827.2007.02084.xSearch in Google Scholar PubMed
73. Oza NM, Siegenthaler M, Horvath K, Rosing DR, Chen MY, et al. Serious aortic complications in a patient with Turner syndrome. Eur J Pediatr 2013;172:703–5.10.1007/s00431-012-1808-3Search in Google Scholar PubMed PubMed Central
74. Kin H, Okabayashi H, Nakajima T, Takahashi K. Aortic dissecting aneurysm with a bicuspid aortic valve in Turner’s syndrome: report of a case. Surgery Today 2007;37:667–70.10.1007/s00595-006-3462-8Search in Google Scholar PubMed
75. Maureira JP, Vanhuyse F, Lekehal M, Hubert T, Vigouroux C, et al. Failure of Marfan anatomic criteria to predict risk of aortic dissection in Turner syndrome: necessity of specific adjusted risk thresholds. Interact Cardiovasc Thorac Surg 2012;14: 610–4.10.1093/icvts/ivr172Search in Google Scholar PubMed PubMed Central
76. Jagannath AD, Rastogi U, Spooner AE, Lin AE, Agnihotri AK. Aortic dissection and moyamoya disease in Turner syndrome. Am J Med Genet A 2010;152A:2085–9.10.1002/ajmg.a.33539Search in Google Scholar PubMed
77. Di Eusanio M, Pilato E, Pantaleo A, Di Bartolomeo R. Type B aortic dissection complicating an isthmic coarctation in a Turner patient. J Cardiovasc Med (Hagerstown). 2012;13:225–8.10.2459/JCM.0b013e32833b9653Search in Google Scholar PubMed
78. Boissonnas CC, Davy C, Bornes M, Arnaout L, Meune C, et al. Careful cardiovascular screening and follow-up of women with Turner syndrome before and during pregnancy is necessary to prevent maternal mortality. Fertil Steril 2009;91:929.e5–7.10.1016/j.fertnstert.2008.09.037Search in Google Scholar
79. Ohl J. [Oocyte donation in Turner syndrome]. Gynecologie, Obstetrique & Fertilite 2008;36:886–90.10.1016/j.gyobfe.2008.06.019Search in Google Scholar
80. Garvey P, Elovitz M, Landsberger EJ. Aortic dissection and myocardial infarction in a pregnant patient with Turner syndrome. Obstet Gynecol 1998;91(5 Pt 2):864.10.1016/S0029-7844(97)00546-2Search in Google Scholar
81. Strader WJ, 3rd, Wachtel HL, Lundberg GD, Jr. Hypertension and aortic rupture in gonadal dysgenesis. J Pediatr 1971;79: 473–5.10.1016/S0022-3476(71)80161-0Search in Google Scholar
82. Vesin S, Chudanova V. [Aortic aneurysm in Turner’s syndrome]. Ceskoslovenska Radiologie 1989;43:226–9.Search in Google Scholar
83. Martin MM, Beekman RH, Rocchini AP, Crowley DC, Rosenthal A. Aortic aneurysms after subclavian angioplasty repair of coarctation of the aorta. Am J Cardiol 1988;61:951–3.10.1016/0002-9149(88)90390-6Search in Google Scholar
84. Edwards WD, Leaf DS, Edwards JE. Dissecting aortic aneurysm associated with congenital bicuspid aortic valve. Circulation 1978;57:1022–5.10.1161/01.CIR.57.5.1022Search in Google Scholar PubMed
85. Donadille B, Rousseau A, Zenaty D, Cabrol S, Courtillot C, et al. Cardiovascular findings and management in Turner syndrome: insights from a French cohort. Eur J Endocrinol 2012;167: 517–22.10.1530/EJE-12-0434Search in Google Scholar PubMed
86. Loscalzo ML, Van PL, Ho VB, Bakalov VK, Rosing DR, et al. Association between fetal lymphedema and congenital cardiovascular defects in Turner syndrome. Pediatrics 2005;115: 732–5.10.1542/peds.2004-1369Search in Google Scholar PubMed
87. Prandstraller D, Mazzanti L, Giardini A, Lovato L, Tamburrino F, et al. Correlations of phenotype and genotype in relation to morphologic remodelling of the aortic root in patients with Turner’s syndrome. Cardiol Young 2009;19:264–71.10.1017/S1047951109004016Search in Google Scholar PubMed
88. Elsheikh M, Casadei B, Conway GS, Wass JA. Hypertension is a major risk factor for aortic root dilatation in women with Turner’s syndrome. Clin Endocrinol (Oxf) 2001;54:69–73.10.1046/j.1365-2265.2001.01154.xSearch in Google Scholar PubMed
89. Bryman I, Sylven L, Berntorp K, Innala E, Bergstrom I, et al. Pregnancy rate and outcome in Swedish women with Turner syndrome. Fertil Steril 2011;95:2507–10.10.1016/j.fertnstert.2010.12.039Search in Google Scholar
90. Hadnott TN, Gould HN, Gharib AM, Bondy CA. Outcomes of spontaneous and assisted pregnancies in Turner syndrome: the U.S. National Institutes of Health experience. Fertil Steril 2011;95:2251–6.10.1016/j.fertnstert.2011.03.085Search in Google Scholar
91. Hovatta O. Pregnancies in women with Turner’s syndrome. Ann Med 1999;31:106–10.10.3109/07853899908998785Search in Google Scholar
92. Hagman A, Kallen K, Bryman I, Landin-Wilhelmsen K, Barrenas ML, et al. Morbidity and mortality after childbirth in women with Turner karyotype. Hum Reprod 2013;28:1961–73.10.1093/humrep/det113Search in Google Scholar
93. Hagman A, Loft A, Wennerholm UB, Pinborg A, Bergh C, et al. Obstetric and neonatal outcome after oocyte donation in 106 women with Turner syndrome: a Nordic cohort study. Hum Reprod 2013;28:1598–609.10.1093/humrep/det082Search in Google Scholar
94. Hagman A, Kallen K, Barrenas ML, Landin-Wilhelmsen K, Hanson C, et al. Obstetric outcomes in women with Turner karyotype. J Clin Endocrinol Metab 2011;96:3475–2.10.1210/jc.2011-1421Search in Google Scholar
95. Karnis MF, Zimon AE, Lalwani SI, Timmreck LS, Klipstein S, et al. Risk of death in pregnancy achieved through oocyte donation in patients with Turner syndrome: a national survey. Fertil Steril 2003;80:498–501.10.1016/S0015-0282(03)00974-9Search in Google Scholar
96. Gomez D, Al Haj Zen A, Borges LF, Philippe M, Gutierrez PS, et al. Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway. J Pathol 2009;218:131–42.10.1002/path.2516Search in Google Scholar
97. Zhou J, Arepalli S, Cheng CM, Bakalov VK, Bondy CA. Perturbation of the transforming growth factor beta system in Turner syndrome. Beijing da xue xue bao Yi xue ban. Journal of Peking University Health Sciences 2012;44:720–4.Search in Google Scholar
98. Lin AE, Lippe BM, Geffner ME, Gomes A, Lois JF, et al. Aortic dilation, dissection, and rupture in patients with Turner syndrome. J Pediatr 1986;109:820–6.10.1016/S0022-3476(86)80700-4Search in Google Scholar
99. Cleemann L, Mortensen KH, Holm K, Smedegaard H, Skouby SO, et al. Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study. Pediatr Cardiol 2010;31:497–504.10.1007/s00246-009-9626-8Search in Google Scholar PubMed
100. Baxter L, Bryant J, Cave CB, Milne R. Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev 2007 (1):CD003887.10.1002/14651858.CD003887.pub2Search in Google Scholar
101. Hughes IP, Choong CS, Harris M, Ambler GR, Cutfield WS, et al. Growth hormone treatment for Turner syndrome in Australia reveals that younger age and increased dose interact to improve response. Clin Endocrinol (Oxf) 2011;74:473–80.10.1111/j.1365-2265.2011.03937.xSearch in Google Scholar
102. Castillo C, Cruzado M, Ariznavarreta C, Gil-Loyzaga P, Lahera V, et al. Body composition and vascular effects of growth hormone administration in old female rats. Exp Gerontol 2003;38:971–9.10.1016/S0531-5565(03)00156-6Search in Google Scholar
103. Erikstrup C, Pedersen LM, Heickendorff L, Ledet T, Rasmussen LM. Production of hyaluronan and chondroitin sulphate proteoglycans from human arterial smooth muscle—the effect of glucose, insulin, IGF-I or growth hormone. Eur 2001;145:193–8.10.1530/eje.0.1450193Search in Google Scholar PubMed
104. Bondy CA, Van PL, Bakalov VK, Ho VB. Growth hormone treatment and aortic dimensions in Turner syndrome. J Clin Endocrinol Metab 2006;91:1785–8.10.1210/jc.2005-2625Search in Google Scholar PubMed
105. Sharma J, Friedman D, Dave-Sharma S, Harbison M. Aortic distensibility and dilation in Turner’s syndrome. Cardiol Young 2009;19:568–72.10.1017/S1047951109990874Search in Google Scholar PubMed
106. Sbarouni E, Georgiadou P, Marathias A, Geroulanos S, Kremastinos DT. D-dimer and BNP levels in acute aortic dissection. Int J Cardiol 2007;122:170–2.10.1016/j.ijcard.2006.11.056Search in Google Scholar PubMed
107. Gutin LS, Bakalov VK, Rosing DR, Arai AE, Gharib AM, et al. N-terminal pro-brain natriuretic peptide levels and aortic diameters. Am Heart J 2012;164:419–24.10.1016/j.ahj.2012.06.021Search in Google Scholar PubMed PubMed Central
108. Rochiccioli P, Battin J, Bertrand AM, Bost M, Cabrol S, et al. Final height in Turner syndrome patients treated with growth hormone. Horm Res 1995;44:172–6.10.1159/000184620Search in Google Scholar PubMed
109. Rochiccioli P, David M, Malpuech G, Colle M, Limal JM, et al. Study of final height in Turner’s syndrome: ethnic and genetic influences. Acta Paediatr 1994;83:305–8.10.1111/j.1651-2227.1994.tb18099.xSearch in Google Scholar PubMed
110. Dawson-Falk KL, Wright AM, Bakker B, Pitlick PT, Wilson DM, et al. Cardiovascular evaluation in Turner syndrome: utility of MR imaging. Australas Radiol 1992;36:204–9.10.1111/j.1440-1673.1992.tb03152.xSearch in Google Scholar
111. Lopez L, Arheart KL, Colan SD, Stein NS, Lopez-Mitnik G, et al. Turner syndrome is an independent risk factor for aortic dilation in the young. Pediatrics 2008;121:e1622–7.10.1542/peds.2007-2807Search in Google Scholar
112. Ostberg JE, Brookes JAS, McCarthy C, Halcox J, Conway GS. A comparison of echocardiography and magnetic resonance imaging in cardiovascular screening of adults with Turner syndrome. J Clin Endocrinol Metab 2004;89:5966–71.10.1210/jc.2004-1090Search in Google Scholar
113. Davies RR, Goldstein LJ, Coady MA, Tittle SL, Rizzo JA, et al. Yearly rupture or dissection rates for thoracic aortic aneurysms: simple prediction based on size. Ann Thorac Surg 2002;73:17–27; discussion -8.10.1016/S0003-4975(01)03236-2Search in Google Scholar
114. Schoenhoff FS, Cameron DE, Matyas G, Carrel TP. Cardiovasc Surg in Marfan syndrome: implications of new molecular concepts in thoracic aortic disease. Future Cardiol 2011;7:557–69.10.2217/fca.11.37Search in Google Scholar PubMed
115. Kaiser T, Kellenberger CJ, Albisetti M, Bergstrasser E, Valsangiacomo Buechel ER. Normal values for aortic diameters in children and adolescents–assessment in vivo by contrast-enhanced CMR-angiography. J Cardiovasc Magn Reson 2008;10:56.10.1186/1532-429X-10-56Search in Google Scholar PubMed PubMed Central
116. Davies RR, Gallo A, Coady MA, Tellides G, Botta DM, et al. Novel measurement of relative aortic size predicts rupture of thoracic aortic aneurysms. Ann Thorac Surg 2006;81:169–77.10.1016/j.athoracsur.2005.06.026Search in Google Scholar PubMed
117. Lanzarini L, Larizza D, Prete G, Calcaterra V, Klersy C. Prospective evaluation of aortic dimensions in Turner syndrome: a 2-dimensional echocardiographic study. J Am Soc Echocardiogr 2007;20:307–13.10.1016/j.echo.2006.08.028Search in Google Scholar PubMed
118. Mortensen KH, Hjerrild BE, Stochholm K, Andersen NH, Sorensen KE, et al. Dilation of the ascending aorta in Turner syndrome – a prospective cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2011;13:24.10.1186/1532-429X-13-24Search in Google Scholar PubMed PubMed Central
119. Mortensen KH, Erlandsen M, Andersen NH, Gravholt CH. Prediction of aortic dilation in Turner syndrome – enhancing the use of serial cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2013;15:47.10.1186/1532-429X-15-47Search in Google Scholar PubMed PubMed Central
120. Burman ED, Keegan J, Kilner PJ. Aortic root measurement by cardiovascular magnetic resonance: specification of planes and lines of measurement and corresponding normal values. Circ Cardiovasc Imaging 2008;1:104–13.10.1161/CIRCIMAGING.108.768911Search in Google Scholar
121. Castro AVBd, Okoshi K, Ribeiro SM, Barbosa MF, Mattos PF, et al. Cardiovascular assessment of patients with Ullrich-Turner’s syndrome on Doppler echocardiography and magnetic resonance imaging. Arq Bras Cardiol 2002;78:51–8.Search in Google Scholar
122. Xiaocheng W, Zhaohui S, Ka B, Junhui X, Lei Z, et al. The expression of calcitonin gene-related Peptide and acetylcholine in the vestibular-related nucleus population of wild-type mice and retinal degeneration fast mice after rotary stimulation. J Mol Neurosci 2013;51:514–21.10.1007/s12031-013-0087-4Search in Google Scholar
123. Ayad RF, Grayburn PA, Ko JM, Filardo G, Roberts WC. Accuracy of two-dimensional echocardiography in determining aortic valve structure in patients >50 years of age having aortic valve replacement for aortic stenosis. Am J Cardiol 2011;108: 1589–99.10.1016/j.amjcard.2011.09.006Search in Google Scholar
124. Brandenburg RO, Jr., Tajik AJ, Edwards WD, Reeder GS, Shub C, et al. Accuracy of 2-dimensional echocardiographic diagnosis of congenitally bicuspid aortic valve: echocardiographic-anatomic correlation in 115 patients. Am J Cardiol 1983;51:1469–73.10.1016/0002-9149(83)90659-8Search in Google Scholar
125. Chan KL, Stinson WA, Veinot JP. Reliability of transthoracic echocardiography in the assessment of aortic valve morphology: pathological correlation in 178 patients. Can J Cardiol 1999;15:48–2.Search in Google Scholar
126. Malaisrie SC, Carr J, Mikati I, Rigolin V, Yip BK, et al. Cardiac magnetic resonance imaging is more diagnostic than 2-dimensional echocardiography in determining the presence of bicuspid aortic valve. J Thorac Cardiovasc Surg 2012;144:370–6.10.1016/j.jtcvs.2011.09.068Search in Google Scholar
127. Roberts WC. The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 1970;26:72–83.10.1016/0002-9149(70)90761-7Search in Google Scholar
128. Lanzarini L, Larizza D, Prete G, Calcaterra V, Meloni G, et al. Aortic dimensions in Turner’s syndrome: two-dimensional echocardiography versus magnetic resonance imaging. J Cardiovasc Med (Hagerstown) 2007;8:428–37.10.2459/01.JCM.0000269716.33435.d3Search in Google Scholar PubMed
129. Hiratzka LF, Bakris GL, Beckman JA, Bersin RM, Carr VF, et al. 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine. Circulation 2010;121:e266–369.Search in Google Scholar
130. Chalas Boissonnas C, Davy C, Marszalek A, Duranteau L, de Ziegler D, et al. Cardiovascular findings in women suffering from Turner syndrome requesting oocyte donation. Hum Reprod 2011;26:2754–62.10.1093/humrep/der262Search in Google Scholar PubMed
131. Akyurek N, Atabek ME, Eklioglu BS, Alp H. Ambulatory blood pressure and subclinical cardiovascular disease in children with Turner syndrome. Pediatr Cardiol 2014;35:57–62.10.1007/s00246-013-0740-2Search in Google Scholar PubMed
132. Freriks K, Timmermans J, Beerendonk CC, Verhaak CM, Netea-Maier RT, et al. Standardized multidisciplinary evaluation yields significant previously undiagnosed morbidity in adult women with Turner syndrome. J Clin Endocrinol Metab 2011;96:E1517–26.10.1210/jc.2011-0346Search in Google Scholar PubMed
133. Giordano R, Forno D, Lanfranco F, Manieri C, Ghizzoni L, et al. Metabolic and cardiovascular outcomes in a group of adult patients with Turner’s syndrome under hormonal replacement therapy. Eur J Endocrinol 2011;164:819–26.10.1530/EJE-11-0002Search in Google Scholar PubMed
134. Bondy CA, Ceniceros I, Van PL, Bakalov VK, Rosing DR. Prolonged rate-corrected QT interval and other electrocardiogram abnormalities in girls with Turner syndrome. Pediatrics 2006;118:e1220–5.10.1542/peds.2006-0776Search in Google Scholar PubMed
135. Bondy CA, Van PL, Bakalov VK, Sachdev V, Malone CA, et al. Prolongation of the cardiac QTc interval in Turner syndrome. Medicine 2006;85:75–81.10.1097/01.md.0000205629.16302.bcSearch in Google Scholar PubMed
136. Practice Committee of American Society For Reproductive Medicine. Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertil Steril 2012;97:282–4.Search in Google Scholar
137. Cabanes L, Chalas C, Christin-Maitre S, Donadille B, Felten ML, et al. Turner syndrome and pregnancy: clinical practice. Recommendations for the management of patients with Turner syndrome before and during pregnancy. Eur J Obstet Gynecol Reprod Biol 2010;152:18–24.10.1016/j.ejogrb.2010.05.019Search in Google Scholar PubMed
138. Cook JR, Nistala H, Ramirez F. Drug-based therapies for vascular disease in Marfan syndrome: from mouse models to human patients. Mt Sinai J Med 2010;77:366–73.10.1002/msj.20200Search in Google Scholar PubMed PubMed Central
139. Hartog AW, Franken R, Zwinderman AH, Groenink M, Mulder BJM. Current and future pharmacological treatment strategies with regard to aortic disease in Marfan syndrome. Expert Opin Pharmacother 2012;13:647–62.10.1517/14656566.2012.665446Search in Google Scholar PubMed
140. Peng H, Carretero OA, Vuljaj N, Liao T-D, Motivala A, et al. Angiotensin-converting enzyme inhibitors: a new mechanism of action. Circulation 2005;112:2436–45.10.1161/CIRCULATIONAHA.104.528695Search in Google Scholar PubMed PubMed Central
141. Ahimastos AA, Aggarwal A, D’Orsa KM, Formosa MF, White AJ, et al. Effect of perindopril on large artery stiffness and aortic root diameter in patients with Marfan syndrome: a randomized controlled trial. J Am Med Assoc 2007;298:1539–47.10.1001/jama.298.13.1539Search in Google Scholar PubMed
142. Brooke BS, Habashi JP, Judge DP, Patel N, Loeys B,et al. Angiotensin II blockade and aortic-root dilation in Marfan’s syndrome. N Engl J Med 2008;358:2787–95.10.1056/NEJMoa0706585Search in Google Scholar PubMed PubMed Central
143. Kataoka K, Ozawa A, Inage A, Benson LN. Transcatheter repair of native coarctation in children with Turner syndrome: three case reports and literature review. Congenit 2006;1:315–20.10.1111/j.1747-0803.2006.00054.xSearch in Google Scholar PubMed
144. Devernay M, Ecosse E, Coste J, Carel J-C. Determinants of medical care for young women with Turner syndrome. J Clin Endocrinol Metab 2009;94:3408–13.10.1210/jc.2009-0495Search in Google Scholar PubMed
©2014 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- Cardiovascular disease and prevention
- Reviews
- Future orientation: a construct with implications for adolescent health and wellbeing
- Aortic dilatation and dissection in Turner syndrome: What we know, what we are unclear about and what we should do in clinical practice?
- Original articles
- Gender differences in early trauma and high-risk behaviors among street-entrenched youth in British Columbia
- Health-promoting lifestyle and its predictors among Iranian adolescent girls, 2013
- Health risk behaviors and sexual initiation among in-school adolescents in rural communities in southwestern Nigeria
- Is change in health behavior of Dutch medical students related to change in their ideas on how a physician’s lifestyle influences their patient’s lifestyle?
- Awareness of current recommendations and guidelines regarding strength training for youth
- Non-medical prescription drug and illicit street drug use among young Swiss men and associated mental health issues
- Prevalence of health behaviors and their associated factors among a sample of university students in India
- Quality of life measures and psychiatric symptoms in adolescents with systemic lupus erythematosus and familial Mediterranean fever
- Risk behaviors related to violence and injury among school-going adolescents in Karnataka, Southern India
- Polycystic ovary syndrome in Iranian adolescents
- Relational stressors as predictors for repeat aggressive and self-harming incidents in child and adolescent psychiatric inpatient settings
- Effect of life skills training on physical activity patterns amongst school adolescents in Delhi: a non-randomized interventional study
- Association of oral hygiene habits and food intake with the risk of dental caries among undergraduate university women in Saudi Arabia
Articles in the same Issue
- Frontmatter
- Editorial
- Cardiovascular disease and prevention
- Reviews
- Future orientation: a construct with implications for adolescent health and wellbeing
- Aortic dilatation and dissection in Turner syndrome: What we know, what we are unclear about and what we should do in clinical practice?
- Original articles
- Gender differences in early trauma and high-risk behaviors among street-entrenched youth in British Columbia
- Health-promoting lifestyle and its predictors among Iranian adolescent girls, 2013
- Health risk behaviors and sexual initiation among in-school adolescents in rural communities in southwestern Nigeria
- Is change in health behavior of Dutch medical students related to change in their ideas on how a physician’s lifestyle influences their patient’s lifestyle?
- Awareness of current recommendations and guidelines regarding strength training for youth
- Non-medical prescription drug and illicit street drug use among young Swiss men and associated mental health issues
- Prevalence of health behaviors and their associated factors among a sample of university students in India
- Quality of life measures and psychiatric symptoms in adolescents with systemic lupus erythematosus and familial Mediterranean fever
- Risk behaviors related to violence and injury among school-going adolescents in Karnataka, Southern India
- Polycystic ovary syndrome in Iranian adolescents
- Relational stressors as predictors for repeat aggressive and self-harming incidents in child and adolescent psychiatric inpatient settings
- Effect of life skills training on physical activity patterns amongst school adolescents in Delhi: a non-randomized interventional study
- Association of oral hygiene habits and food intake with the risk of dental caries among undergraduate university women in Saudi Arabia