Startseite Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19
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Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19

  • Bianca Schrul EMAIL logo und Wolfgang Schliebs
Veröffentlicht/Copyright: 3. März 2018

Abstract

In order to adapt to environmental changes, such as nutrient availability, cells have to orchestrate multiple metabolic pathways, which are catalyzed in distinct specialized organelles. Lipid droplets (LDs) and peroxisomes are both endoplasmic reticulum (ER)-derived organelles that fulfill complementary functions in lipid metabolism: Upon nutrient supply, LDs store metabolic energy in the form of neutral lipids and, when energy is needed, supply fatty acids for oxidation in peroxisomes and mitochondria. How these organelles communicate with each other for a concerted metabolic output remains a central question. Here, we summarize recent insights into the biogenesis and function of LDs and peroxisomes with emphasis on the role of PEX19 in these processes.

Acknowledgments

We are grateful to David Mick for critical reading of the manuscript and valuable comments. While we attempted a balanced literature review within the scope of this article, we apologize to all our colleagues whose work could not be cited due to space restrictions.

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Received: 2018-01-16
Accepted: 2018-02-23
Published Online: 2018-03-03
Published in Print: 2018-06-27

©2018 Walter de Gruyter GmbH, Berlin/Boston

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