EDD1 predicts prognosis and regulates gastric cancer growth in vitro and in vivo via miR-22
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Abstract
Gastric cancer is the most common digestive malignant tumor worldwild. EDD1 was reported to be frequently amplified in several tumors and played an important role in the tumorigenesis process. However, the biological role and potential mechanism of EDD1 in gastric cancer remains poorly understood. In this study, we are aim to investigate the effect of EDD1 on gastric cancer progression and to explore the underlying mechanism. The results showed the significant up-regulation of EDD1 in -gastric cancer cell tissues and lines. The expression level of EDD1 was also positively associated with advanced clinical stages and predicted poor overall patient survival and poor disease-free patient survival. Besides, EDD1 knockdown markedly inhibited cell viability, colony formation, and suppressed tumor growth. Opposite results were obtained in gastric cancer cells with EDD1 overexpression. EDD1 knockdown was also found to induce gastric cancer cells apoptosis. Further investigation indicated that the oncogenic role of EDD1 in regulating gastric cancer cells growth and apoptosis was related to its PABC domain and directly through targeting miR-22, which was significantly down-regulated in gastric cancer tissues. Totally, our study suggests that EDD1 plays an oncogenic role in gastric cancer and may be a potential therapeutic target for gastric cancer.
© 2016 by Walter de Gruyter Berlin/Boston
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Articles in the same Issue
- Retraction Note to the article: “EDD1 predicts prognosis and regulates gastric cancer growth in vitro and in vivo via miR-22“
- EDD1 predicts prognosis and regulates gastric cancer growth in vitro and in vivo via miR-22
- Retraction Note to the article “Up-regulation of miR-125b reverses epithelial-mesenchymal transition in paclitaxel-resistant lung cancer cells
- Up-regulation of miR-125b reverses epithelial-mesenchymal transition in paclitaxel-resistant lung cancer cells
- Mechanistic insights into Ras-catalyzed GTP hydrolysis: conformational dynamics, catalytic mechanisms, and emerging therapeutic strategies
- Inhibition of Aβ(40) peptide aggregation by Milk-derived Amyloid-like Protein Aggregates (MAPA)
- Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra
- Molecular mechanisms shaping the actin filament scaffold of dendritic filopodia
- CCM scaffolds at the frontier of biomechanics: their roles in vascular physiology and disease
- Endocytic scaffolds at the crossroads of Alzheimer’s disease and neuronal aging
- Albrecht Kossel and the nucleobases – a review of his life and work
- Intersectins as versatile scaffolds for membrane-associated processes
- Development of kallikrein-related peptidase 7 (KLK7) inhibitors and use in a species-adapted model for ovarian cancer
- Felix Hoppe-Seyler (1825–1895): a pioneer in the field of biochemistry with many significant contributions to the development of the discipline
