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A role for NGF and its receptors TrKA and p75NTR in the progression of COPD

  • Anna Stabile , Alessandra Pistilli , Lucia Crispoltoni , Claudia Montagnoli , Roberto Tiribuzi , Lucio Casali and Mario Rende EMAIL logo
Published/Copyright: September 25, 2015
Biological Chemistry
From the journal Biological Chemistry Volume 397 Issue 2

Abstract

Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease progression. In fact, for the first time, this study evaluates the presence of nerve growth factor and its receptors in serum and in peripheral blood mononuclear cells of patients with different stages of chronic obstructive pulmonary disease compared to healthy subjects, non-smoker and current smoker. Serum monocyte chemoattractant protein-1, tumor necrosis factor-α, interleukin-10 and forced expiratory volume in 1 s were also analyzed. Compared to healthy subjects, chronic obstructive pulmonary disease patients presented a staging-dependent increase in serum nerve growth factor, negatively correlated to forced expiratory volume in 1 s and positively to monocyte chemoattractant Protein-1. The percentage of p75NTR+ peripheral blood mononuclear cells increased in early stages of chronic obstructive pulmonary disease (I–II), while TrKA+ peripheral blood mononuclear cells increased in late stages (III–IV). Our data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging.

Keywords: airways diseases; cytokines; neurotrophin receptors; neurotrophins; smoking habit
Corresponding author: Mario Rende, Section of Human, Clinical and Forensic Anatomy, Department of Surgery and Biomedical Sciences, School of Medicine, P.le Lucio Severi 1, Sant’Andrea delle Fratte 06132 Perugia, Italy, e-mail:

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Received: 2015-7-8
Accepted: 2015-9-21
Published Online: 2015-9-25
Published in Print: 2016-1-1

©2016 by De Gruyter

Articles in the same Issue

  1. Frontmatter
  2. Research Articles/Short Communications
  3. Genes and Nucleic Acids
  4. Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors
  5. Protein Structure and Function
  6. Crystal structure of cleaved vaspin (serpinA12)
  7. Semi-purification procedures of prions from a prion-infected brain using sucrose has no influence on the nonenzymatic glycation of the disease-associated prion isoform
  8. Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity
  9. Membranes, Lipids, Glycobiology
  10. De novo ceramide synthesis is involved in acute inflammation during labor
  11. Cell Biology and Signaling
  12. A role for NGF and its receptors TrKA and p75NTR in the progression of COPD
  13. Proteolysis
  14. Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
https://doi.org/10.1515/hsz-2015-0208
Keywords for this article
airways diseases; cytokines; neurotrophin receptors; neurotrophins; smoking habit

Articles in the same Issue

  1. Frontmatter
  2. Research Articles/Short Communications
  3. Genes and Nucleic Acids
  4. Acute hypothalamo-pituitary-adrenal axis response to LPS-induced endotoxemia: expression pattern of kinin type B1 and B2 receptors
  5. Protein Structure and Function
  6. Crystal structure of cleaved vaspin (serpinA12)
  7. Semi-purification procedures of prions from a prion-infected brain using sucrose has no influence on the nonenzymatic glycation of the disease-associated prion isoform
  8. Involvement of loop 5 lysine residues and the N-terminal β-hairpin of the ribotoxin hirsutellin A on its insecticidal activity
  9. Membranes, Lipids, Glycobiology
  10. De novo ceramide synthesis is involved in acute inflammation during labor
  11. Cell Biology and Signaling
  12. A role for NGF and its receptors TrKA and p75NTR in the progression of COPD
  13. Proteolysis
  14. Inhibition of endopeptidase and exopeptidase activity of cathepsin B impairs extracellular matrix degradation and tumour invasion
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