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Voltage-dependent anion channels: the wizard of the mitochondrial outer membrane

  • Barbara Mertins , Georgios Psakis and Lars-Oliver Essen EMAIL logo
Published/Copyright: August 20, 2014

Abstract

Voltage dependent anion channels (VDACs) are the most abundant proteins in the outer mitochondrial membrane. Although they are essential in metabolite exchange, cell defense and apoptosis, the molecular mechanism of these VDAC-mediated processes remains elusive. Here we review recent progress in terms of VDACs’ structure and regulation, with a special focus on the molecular aspects of gating and the interaction with effector proteins.


Corresponding author: Lars-Oliver Essen, Karl-von-Frisch-Straße 8, D-35032 Marburg, Germany, e-mail: ; and Departments of Chemistry and Biology, Philipps-University Marburg, Hans-Meerwein-Straße 4, D-35032 Marburg, Germany

Funding source: Deutsche Forschungsgemeinschaft

Award Identifier / Grant number: (Grant/Award Number: ‘ES 152/8-1’)

Acknowledgments

The authors wish to thank Deutsche Forschungsgemeinschaft for funding (ES 152/8-1), Michael Kock for help with ConSurf analysis, Dr Gert Bange for helpful discussions and Dr Sophia-Louisa Tsougarakis for the line editing of this manuscript.

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Received: 2014-5-30
Accepted: 2014-8-18
Published Online: 2014-8-20
Published in Print: 2014-12-1

©2014 by De Gruyter

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