Home Life Sciences The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves
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The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves

  • Antonietta Bernardo , Roberta De Simone , Chiara De Nuccio , Sergio Visentin and Luisa Minghetti EMAIL logo
Published/Copyright: June 14, 2013

Abstract

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is one of the most studied nuclear receptor since its identification as a target to treat metabolic and neurological diseases. In addition to exerting anti-inflammatory and neuroprotective effects, PPAR-γ agonists, such as the insulin-sensitizing drug pioglitazone, promote the differentiation of oligodendrocytes (OLs), the myelin-forming cells of the central nervous system (CNS). In addition, PPAR-γ agonists increase OL mitochondrial respiratory chain activity and OL’s ability to respond to environmental signals with oscillatory Ca2+ waves. Both OL maturation and oscillatory Ca2+ waves are prevented by the mitochondrial inhibitor rotenone and restored by PPAR-γ agonists, suggesting that PPAR-γ promotes myelination through mechanisms involving mitochondria.


Corresponding author: Luisa Minghetti, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161 Rome, Italy, e-mail:

This study was supported by FISM – Fondazione Italiana Sclerosi Multipla, Grant 2011/R/15.

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Received: 2013-3-22
Accepted: 2013-6-13
Published Online: 2013-06-14
Published in Print: 2013-12-01

©2013 by Walter de Gruyter Berlin Boston

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