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Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia

  • Matthias Weider

    Matthias Weider studied biology at the University of Erlangen-Nürnberg, Germany. He received his PhD in 2006 on vitamin-dependent transcriptional regulation in yeast. Since 2008 he is a postdoctoral fellow in the group of Michael Wegner. His current research interests are target genes and interaction partners of Sox10, especially the BAF complex.

         , Simone Reiprich

    Simone Reiprich holds a Diploma in Molecular Medicine. In 2010, she earned her PhD working on the “Impact of Sox E transcription factors on the development of neural crest derivatives”. Since then she is a postdoctoral fellow in the group of Michael Wegner focussing on regulatory networks in the development of glial cells in the nervous system.

         and Michael Wegner

    Michael Wegner studied biology at the Universities of Münster and Würzburg. After obtaining his PhD in 1990, he spent three years as a postdoctoral fellow at the University of California at San Diego before taking up a group leader position at the Centre for Molecular Neurobiology in Hamburg. Since 2000, he is a Professor of Biochemistry and Pathobiochemistry at the University of Erlangen-Nürnberg. His research is centred around the transcriptional regulation of neural development with a special emphasis on Sox proteins.

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Published/Copyright: May 20, 2013
Biological Chemistry
From the journal Biological Chemistry Volume 394 Issue 12

Abstract

Sox10 belongs to the Sox family of high-mobility group-box transcription factors. It fulfils widespread and essential functions in myelinating glia at multiple stages of development such as glial specification, survival and terminal differentiation. To a large extent, these diverse activities can be attributed to its capacity to interact with different transcription factors in distinct regulatory networks. Beyond transcription factors, an increasing number of interaction partners are emerging with alternative impact on gene expression. These include components of the mediator complex, the Brahma-associated factor complex and histone deacetylases. Here, we discuss interactions with functional relevance in myelinating glia and link Sox10 function in these cells not only to gene transcription, but also to epigenetics and chromatin remodeling.

Keywords: BAF; chromatin; HDAC; mediator; oligodendrocyte; Schwann cell
Corresponding author: Michael Wegner, Institut für Biochemie, Emil-Fischer-Zentrum, Universität Erlangen-Nürnberg, D-91054 Erlangen, Germany, e-mail:

About the authors

Matthias Weider

Matthias Weider studied biology at the University of Erlangen-Nürnberg, Germany. He received his PhD in 2006 on vitamin-dependent transcriptional regulation in yeast. Since 2008 he is a postdoctoral fellow in the group of Michael Wegner. His current research interests are target genes and interaction partners of Sox10, especially the BAF complex.

Simone Reiprich

Simone Reiprich holds a Diploma in Molecular Medicine. In 2010, she earned her PhD working on the “Impact of Sox E transcription factors on the development of neural crest derivatives”. Since then she is a postdoctoral fellow in the group of Michael Wegner focussing on regulatory networks in the development of glial cells in the nervous system.

Michael Wegner

Michael Wegner studied biology at the Universities of Münster and Würzburg. After obtaining his PhD in 1990, he spent three years as a postdoctoral fellow at the University of California at San Diego before taking up a group leader position at the Centre for Molecular Neurobiology in Hamburg. Since 2000, he is a Professor of Biochemistry and Pathobiochemistry at the University of Erlangen-Nürnberg. His research is centred around the transcriptional regulation of neural development with a special emphasis on Sox proteins.

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Received: 2013-3-8
Accepted: 2013-5-15
Published Online: 2013-05-20
Published in Print: 2013-12-01

©2013 by Walter de Gruyter Berlin Boston

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Guest Editorial
  4. Highlight: perspectives in molecular neurobiology
  5. HIGHLIGHT: PERSPECTIVES IN MOLECULAR NEUROBIOLOGY
  6. Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain
  7. Molecular triggers of neuroinflammation in mouse models of demyelinating diseases
  8. Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia
  9. MeCP2 phosphorylation in the brain: from transcription to behavior
  10. The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves
  11. G-protein-coupled designer receptors – new chemical-genetic tools for signal transduction research
  12. Prolonged cultivation of hippocampal neural precursor cells shifts their differentiation potential and selects for aneuploid cells
  13. Reviews
  14. Eternity and functionality – rational access to physiologically relevant cell lines
  15. Structural and functional insights into the Spir/formin actin nucleator complex
https://doi.org/10.1515/hsz-2013-0146
Keywords for this article
BAF; chromatin; HDAC; mediator; oligodendrocyte; Schwann cell

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Guest Editorial
  4. Highlight: perspectives in molecular neurobiology
  5. HIGHLIGHT: PERSPECTIVES IN MOLECULAR NEUROBIOLOGY
  6. Role of the peroxisome proliferator-activated receptors (PPAR)-α, β/δ and γ triad in regulation of reactive oxygen species signaling in brain
  7. Molecular triggers of neuroinflammation in mouse models of demyelinating diseases
  8. Sox appeal – Sox10 attracts epigenetic and transcriptional regulators in myelinating glia
  9. MeCP2 phosphorylation in the brain: from transcription to behavior
  10. The nuclear receptor peroxisome proliferator-activated receptor-γ promotes oligodendrocyte differentiation through mechanisms involving mitochondria and oscillatory Ca2+ waves
  11. G-protein-coupled designer receptors – new chemical-genetic tools for signal transduction research
  12. Prolonged cultivation of hippocampal neural precursor cells shifts their differentiation potential and selects for aneuploid cells
  13. Reviews
  14. Eternity and functionality – rational access to physiologically relevant cell lines
  15. Structural and functional insights into the Spir/formin actin nucleator complex
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