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Cerebral cavernous malformation is a vascular disease associated with activated RhoA signaling
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Bryan T. Richardson
Published/Copyright:
December 4, 2012
Abstract
Cerebral cavernous malformation (CCM) involves the homozygous inactivating mutations of one of three genes, ccm1, -2, or -3 resulting in hyperpermeable blood vessels in the brain. The CCM1, -2, and -3 proteins form a complex to organize the signaling networks controlling endothelial cell physiology including actin dynamics, tube formation, and adherens junctions. The common biochemical defect with the loss of CCM1, -2, or -3 is increased RhoA activity leading to the activation of Rho-associated coiled coil-forming kinase (ROCK). Inhibition of the ROCK rescues CCM endothelial cell dysfunction, suggesting that the inhibition of RhoA-ROCK signaling may be a therapeutic strategy to prevent or arrest the progression of the CCM lesions.
Received: 2012-6-28
Accepted: 2012-8-13
Published Online: 2012-12-04
Published in Print: 2013-01-01
©2012 by Walter de Gruyter Berlin Boston
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