Protease-dependent mechanisms of complement evasion by bacterial pathogens
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Michal Potempa
Michal Potempa received the PhD in Biochemistry from Jagiellonian University, Krakow, Poland in 2012. Before this he conducted research at the University of Lund on the influence of bacterial proteases on the complement system. After completing his PhD he moved to Josef Stefan Institute, Ljubljana, Slovenia where he, as a postdoc, investigates an interaction between cathepsins and regulators of complement activation on the host and tumor cells.
and
Jan Potempa
Jan Potempa earned his PhD and D.Sc (habilitation) in Biochemistry from Jagiellonian University, Krakow, Poland. In 1985–1988 he conducted postdoctoral research at the University of Georgia and from 1989 he worked there as Senior Research Scientist. In 2009, he moved to the University of Louisville Dental School, were he holds the position of Professor and Academic Scholar. Simultaneously, he maintains a teaching and research position at the Jagiellonian University, where he is Head of the Department of Microbiology and Research Professor. His scientific interest is focused on proteolytic enzymes of bacterial pathogens that play roles in the deregulation of a number of physiological pathways and evasion of host immunity.
©2012 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: The universe of proteolytic networks and mechanisms
- Highlight: 7th General Meeting of the International Proteolysis Society
- Current and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity
- Understanding the substrate specificity of conventional calpains
- Protease-dependent mechanisms of complement evasion by bacterial pathogens
- An ensemble view of thrombin allostery
- Processive proteolysis by γ-secretase and the mechanism of Alzheimer’s disease
- TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections
- A catalogue of putative HIV-1 protease host cell substrates
- Identifi cation of protease exosite-interacting peptides that enhance substrate cleavage kinetics
- A plant Kunitz-type inhibitor mimics bradykinin-induced cytosolic calcium increase and intestinal smooth muscle contraction
- Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice
- Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes
- Review
- Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis
- Minireviews
- Redox Biology on the rise
- Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis
- Research Articles/Short Communications
- Protein Structure and Function
- Insights into the modulation of optimum pH by a single histidine residue in arginine deiminase from Pseudomonas aeruginosa
Articles in the same Issue
- Masthead
- Masthead
- Guest Editorial
- Highlight: The universe of proteolytic networks and mechanisms
- Highlight: 7th General Meeting of the International Proteolysis Society
- Current and prospective applications of non-proteinogenic amino acids in profiling of proteases substrate specificity
- Understanding the substrate specificity of conventional calpains
- Protease-dependent mechanisms of complement evasion by bacterial pathogens
- An ensemble view of thrombin allostery
- Processive proteolysis by γ-secretase and the mechanism of Alzheimer’s disease
- TMPRSS4 is a type II transmembrane serine protease involved in cancer and viral infections
- A catalogue of putative HIV-1 protease host cell substrates
- Identifi cation of protease exosite-interacting peptides that enhance substrate cleavage kinetics
- A plant Kunitz-type inhibitor mimics bradykinin-induced cytosolic calcium increase and intestinal smooth muscle contraction
- Characterisation and metabolism of astroglia-rich primary cultures from cathepsin K-deficient mice
- Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes
- Review
- Synthesis and biological actions of diphosphoinositol phosphates (inositol pyrophosphates), regulators of cell homeostasis
- Minireviews
- Redox Biology on the rise
- Adipose triglyceride lipase in immune response, inflammation, and atherosclerosis
- Research Articles/Short Communications
- Protein Structure and Function
- Insights into the modulation of optimum pH by a single histidine residue in arginine deiminase from Pseudomonas aeruginosa
