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Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions
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Marc Behrendt
Published/Copyright:
June 1, 2012
Abstract
Cadherin-related protein 24 (CDHR24) is a potential tumor suppressor located apically as well as laterally in polarized cells. Here, the role of CDHR24 in contributing to cell morphology and polarity is examined. CDHR24 was predominantly localized at the nonattached part of nonpolarizing cells while another apically sorted protein, aminopeptidase N, was equally distributed over the plasma membrane. Furthermore, CDHR24 expression induced cell aggregation capacity, indicating direct cell-cell interaction. The transepithelial resistance, however, was elevated in polarized MDCK cells, but not in nonpolarizing CHO cells. Our data propose a model in which CDHR24 is directly involved in cell and tissue morphogenesis.
Keywords: cell-cell interaction; cell differentiation; cell polarity; protein-protein interactions; protein sorting; tumor suppressor
Received: 2011-8-27
Accepted: 2012-3-27
Published Online: 2012-06-01
Published in Print: 2012-06-01
©2012 by Walter de Gruyter Berlin Boston
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Keywords for this article
cell-cell interaction;
cell differentiation;
cell polarity;
protein-protein interactions;
protein sorting;
tumor suppressor
Articles in the same Issue
- Review
- The critical role of adrenomedullin and its binding protein, AMBP-1, in neuroprotection
- Minireview
- Ubiquilins in the crosstalk among proteolytic pathways
- Protein Structure and Function
- A non-cytotoxic but ribonucleolytically specific ribotoxin variant: implication of tryptophan residues in the cytotoxicity of hirsutellin A
- The composite nature of the interaction between nuclear receptors EcR and DHR38
- Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2
- New ketomethylene inhibitor analogues: synthesis and assessment of structural determinants for N-domain selective inhibition of angiotensin-converting enzyme
- Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions
- Molecular Medicine
- Analysis of tissue and salivary nicotinamide N-methyltransferase in oral squamous cell carcinoma: basis for the development of a noninvasive diagnostic test for early-stage disease
- Cell Biology and Signaling
- Mitochondrial protein import pathways are functionally conserved among eukaryotes despite compositional diversity of the import machineries
- Small molecule inhibitors of the c-Jun N-terminal kinase (JNK) possess antiviral activity against highly pathogenic avian and human pandemic influenza A viruses
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