Optimizing ICSI outcomes in women with PCOS: the influence of BMI, hormonal levels, and male fertility parameters
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Muhjah Falah Hassan
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Hind Abdul Kadim
Abstract
Objectives
Women with PCOS often experience significant difficulties in achieving spontaneous pregnancy. Intracytoplasmic sperm injection (ICSI) is a viable treatment option for these patients, offering an acceptable success rate. This study purposes to identify factors that may positively or negatively influence pregnancy rates in PCOS women undergoing ICSI and explore potential modifications to enhance successful pregnancy outcomes.
Methods
The study included ninety sub-fertile couples with female partners with diagnosed PCOS. Comprehensive evaluations of the partners included medical history, physical examination, hormonal analysis, transvaginal ultrasound (TVUS), and seminal fluid analysis. All couples underwent ICSI. Pregnancy rates were determined by positive pregnancy tests 14 days after fresh embryo transfer, and participants were divided into two groups: pregnant and non-pregnant.
Results
Of the 90 women who underwent ICSI cycles, 24 achieved pregnancies, resulting in a pregnancy rate of 26.66 %. Non-pregnant women had significantly higher body mass indices (BMI). Additionally, women with elevated cycle day 2 serum estradiol (E2) levels and low follicle-stimulating hormone (FSH) levels exhibited significantly lower pregnancy rates. Women whose male partners had abnormal semen parameters also demonstrated significantly lower pregnancy rates.
Conclusions
Several factors negatively impact pregnancy rates in PCOS women undergoing ICSI, including high BMI, elevated E2, low FSH levels on cycle day 2, a lower number of mature oocytes, and male factor sub-fertility. Many of these factors can be mitigated through the use of ICSI, thereby improving the chances of achieving a successful pregnancy.
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Research ethics: The study followed on obtaining the human ethical clearance from the Medical Research Bioethical Committee of University of Kerbala, College of Medicine (6/26-1-2022).
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Informed consent: The investigators have obtained the written consents of participation from the respondents.
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Author contributions: MFH, HAK designed and planned the article, MFH, HAK, RZAY, SH performed the experiments, MFH, SD, PS analysed the data, wrote the article, made the final revisions. All the authors have read and approved the manuscript.
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Competing interests: The authors declare that they do not have any conflict of interest.
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Research funding: None.
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Data availability: Data will be available from the investigators.
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Articles in the same Issue
- Frontmatter
- Original Articles
- Randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxide levels in individuals at risk for hypertension
- Evaluation of diagnostic potential of maternal serum ischemia modified albumin in cases of pre-eclampsia
- Hypothalamus-pituitary-adrenal axis in patients with post-traumatic stress disorders and related to oxidative stress
- Evaluation of the effect of taurine on the matrix metalloproteinase-9 and the expression changes of miRNA-21 and miRNA-146a in SH-SY5Y cell line
- Review Article
- Unveiling bisphenol A toxicity: human health impacts and sustainable treatment strategies
- Original Article
- Optimizing ICSI outcomes in women with PCOS: the influence of BMI, hormonal levels, and male fertility parameters
