Basic pituitary-ovarian hormones and ultrasound parameters of uterine appendages in full-term and preterm neonate girls
-
Natalia Artymuk
and
Elena Nikulina
Abstract
Objective
To determine the basic pituitary-ovarian hormones and ultrasound parameters of uterine appendages in full-term and preterm newborn girls.
Materials and methods
One hundred full-term and premature newborn girls (58 and 42, respectively) were studied with clinical, instrumental, laboratory (enzyme immunoassay) and statistical methods.
Results
Statistically significant differences in the pituitary-ovarian hormones and ultrasound parameters of uterine appendages in preterm neonate girls compared to full-term girls were defined. The pituitary hormone levels (follicle-stimulating and luteinizing hormone levels) were higher in preterm newborn girls [0.15 (0.06–0.53) and 0.06 (0.05–0.08) (p = 0.0001); 0.03 (0.00–0.23) and 0.00 (0.00–0.03), (p = 0.003)]; the ovarian hormone levels (estradiol, anti-Müllerian hormone and inhibin В levels) were lower [0.44 (0.25–0.85) and 1.55 (1.06–1.84) (p = 0.0001); 2.73 (2.12–3.65) and 3.66 (2.59–5.0), (p = 0.026), 60.81 (37.19–128.80) and 104.75 (54.35–159.18), (p = 0.019), respectively]. Ultrasound investigation showed that the ovarian reserve in preterm neonates was smaller compared to the full-term neonates [38.48 (22.01–56.49) and 102.47 (85.36–111.37), (p = 0.0001); 36.95 (25.21–70.59) and 108.05 (91.74–116.44), (p = 0.0001), respectively (p = 0.0001)]. The number of antral follicles in the slice was also statistically significantly smaller [2 – in the right ovary, 1 – in the left ovary, vs. 4 and 4, respectively (p = 0.0001)].
Conclusion
Premature neonates have different pituitary-ovarian hormones and ovarian size compared to full-term babies.
Acknowledgements
The authors are grateful to their scientific supervisor Professor Galina A. Ushakova.
Author Statement
Research funding: Test systems for hormonal studies were paid by the Kemerovo Regional Children’s Clinical Hospital, Kemerovo, Russia, represented by the Director Mikhail I. Likstanov, MD, PhD, Doctor of Medical Sciences.
Conflict of interest: The authors report no conflicts of interest.
Informed consent: Informed consent was obtained from all participants.
Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies and was performed in accordance with the tenets of the Helsinki Declaration and has been approved by the author’s institutional review board or equivalent committee.
References
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Articles in the same Issue
- Original Articles
- Management of women with PCOS using myo-inositol and folic acid. New clinical data and review of the literature
- Melatonin has a protective effect against lipid peroxidation in the bone tissue of diabetic rats subjected to acute swimming exercise
- Short Communication
- Basic pituitary-ovarian hormones and ultrasound parameters of uterine appendages in full-term and preterm neonate girls
- Case Report
- A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis
