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Vitamin D and male reproductive system

  • Pablo R. Costanzo EMAIL logo and Pablo Knoblovits
Published/Copyright: November 30, 2016
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 28 Issue 3

Abstract

Vitamin D deficiency is a highly prevalent worldwide condition and affects people of all ages. The most important role of vitamin D is the regulation of intestinal calcium absorption and metabolism of calcium and phosphorus to maintain muscle and bone homeostasis. Furthermore, in recent years it has been discovered that the vitamin D receptor (VDR) is widely distributed in many organs and tissues where vitamin D can perform other actions that include the modulation of the immune response, insulin secretion, anti-proliferative effect on cells of vascular smooth muscle, modulation of the renin-angiotensin-aldosterone system and regulates cell growth in several organs. The VDR is widely distributed in the male reproductive system. Vitamin D induces changes in the spermatozoa’s calcium and cholesterol content and in protein phosphorylation to tyrosine/threonine residues. These changes could be involved in sperm capacitation. Vitamin D seems to regulate aromatase expression in different tissues. Studies analyzing seasonal variations of sex steroids in male populations yield conflicting results. This is probably due to the wide heterogeneity of the populations included according to age, systemic diseases and obesity.

Keywords: male fertility; testosterone; vitamin D
Corresponding author: Pablo R. Costanzo, MD, Endocrinology Division, Hospital Italiano de Buenos Aires, San Juan Avenue 4244 8th Floor, 20. CP 1233, Buenos Aires, Argentina, Phone: (54-11) 49610610

  1. Author Statement

  2. Funding: Authors state no funding involved.

  3. Conflict of interest: Authors state no conflict of interest.

  4. Informed consent: Informed consent is not applicable.

  5. Ethical approval: The conducted research is not related to either human or animals use.

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Received: 2016-10-15
Accepted: 2016-11-2
Published Online: 2016-11-30
Published in Print: 2016-12-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. TOPIC C: Bone Patho-Physiology and Related Disorders: Therapeutic and Clinical Impacts
  3. Review Articles
  4. Adipose derived stem cells for regenerative therapy in osteoarticular diseases
  5. The pathophysiological basis of bone tissue alterations associated with eating disorders
  6. Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity
  7. Vitamin D and male reproductive system
https://doi.org/10.1515/hmbci-2016-0049
Keywords for this article
male fertility; testosterone; vitamin D

Articles in the same Issue

  1. Frontmatter
  2. TOPIC C: Bone Patho-Physiology and Related Disorders: Therapeutic and Clinical Impacts
  3. Review Articles
  4. Adipose derived stem cells for regenerative therapy in osteoarticular diseases
  5. The pathophysiological basis of bone tissue alterations associated with eating disorders
  6. Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity
  7. Vitamin D and male reproductive system
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