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The evolution of genomic stability to a mechanism in reproduction and psychiatry

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Published/Copyright: June 7, 2016
Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 29 Issue 1

Abstract

There are two forms of immune defense, the specific or adaptive immune defense and the unspecific innate immune defense. Vaccination is utilized against specific bacteria via the adaptive immune system. The innate immunity DNA stress defense is a non-toxic mechanism developed in yeasts and conserved in mammals and in plants. Although the steroidal hormone cascade has overtaken the stress response and allows superfast response via non-genomic receptors, the old innate immunity response is still mediated via the steroidal hormones cascade. The classical drug/receptor model has provided for many solutions, however, in antibiotics, cancer, and in severe mental diseases this model reaches to certain limits. The NIH/Department of Mental Health has developed a new model that shows severe mental diseases may be immune diseases that can be treated by replacing old diseased nerve cells by new healthy nerve cells, where the old innate immunity may be exploited. This means that severe mental diseases are physical diseases. A newly developed model, where modifications of the steroidal hormone cascade help to understand bipolarity, schizophrenia, and PTSD in men and women can be transferred to gynecological hormone modifications in women, where innate immunity is mediated via the same steroidal hormone cascade. Treatment via immune response via the DNA cascade should be developed in cancer, infections and severe mental disease, because foreign cells or diseased cells may be removed by the unspecific innate immunity.

Keywords: BAX; cell differentiation; cholesterol; DNA repair; estradiol; innate immunity; MAPkinase; yeast
Corresponding author: PD Dr. med. Pedro-Antonio Regidor, Exeltis Germany GmbH, Adalperostraße 84, 85737 Ismaning, Germany

Acknowledgments:

This publication is the posthumous work of Dr. Uwe Rohr who struggled continuously in life for the development of a better understanding of the hormonal interactions and its influence on several diseases.

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Received: 2016-2-22
Accepted: 2016-3-23
Published Online: 2016-6-7
Published in Print: 2017-1-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. The evolution of genomic stability to a mechanism in reproduction and psychiatry
  4. Original Articles
  5. 17β-Estradiol suppresses visceral adipogenesis and activates brown adipose tissue-specific gene expression
  6. Expression, purification and characterization of human cytosolic sulfotransferase (SULT) 1C4
  7. Letter to the Editor
  8. Comment on: “Is there a role for vitamin D in human reproduction?”
https://doi.org/10.1515/hmbci-2016-0013
Keywords for this article
BAX; cell differentiation; cholesterol; DNA repair; estradiol; innate immunity; MAPkinase; yeast

Articles in the same Issue

  1. Frontmatter
  2. Review Article
  3. The evolution of genomic stability to a mechanism in reproduction and psychiatry
  4. Original Articles
  5. 17β-Estradiol suppresses visceral adipogenesis and activates brown adipose tissue-specific gene expression
  6. Expression, purification and characterization of human cytosolic sulfotransferase (SULT) 1C4
  7. Letter to the Editor
  8. Comment on: “Is there a role for vitamin D in human reproduction?”
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