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Aldosterone and type 2 diabetes mellitus

  • Guido Zavatta , Elena Casadio , Eleonora Rinaldi , Uberto Pagotto , Renato Pasquali and Valentina Vicennati EMAIL logo
Published/Copyright: February 13, 2016

Abstract

Primary hyperaldosteronism (PA) has recently been demonstrated to be strictly associated to metabolic syndrome as compared with essential hypertension (EH). Besides, the characteristics of metabolic syndrome are different in PA compared to EH, as high fasting glucose is more frequent in the former condition. The adverse effect of excess aldosterone on insulin metabolic signaling has generated increasing interest in the role of hyperaldosteronism in the pathogenesis of insulin resistance and resistant hypertension. Moreover, aldosterone receptor antagonist therapy in diabetic and cardiopathic patients improved coronary flow. The aim of this review is to present recent knowledge about the relationship between aldosterone, insulin resistance and diabetes.


Corresponding author: Valentina Vicennati, Endocrinology Unit, Department of Medical and Surgical Sciences, Alma Mater Studiorum-University of Bologna, Policlinico S.Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy, Phone: +39-0512144310, Fax: +39-0516363080, E-mail:

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Received: 2015-11-16
Accepted: 2016-1-18
Published Online: 2016-2-13
Published in Print: 2016-4-1

©2016 by De Gruyter

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