Home Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action
Article
Licensed
Unlicensed Requires Authentication

Hormones: electron emission, communication, mutual interaction, regeneration, metabolites, carcinogenesis and receptor action

  • Nikola Getoff EMAIL logo
Published/Copyright: October 2, 2012

Abstract

This review discusses the highlights of the recently made discovery about the ability of hormones to eject ‘solvated electrons’ (eaq) in water containing media. The resulting consequences for communication with other biological systems by the electron-transfer process, formation of metabolites, the possible initiation of cancer, hormone regeneration and the action of hormone-receptor systems are briefly discussed. The molecular structure of the hormones and the environment are hereby found to be the most important determining factors for the yield of ejected eaq. Furthermore, the hormone transients, which result from emission of eaq–, are reviewed, as well as the formation of metabolites, which can be involved in various biological processes. The hormone-transients can also be regenerated by electron-transfer from a potent electron donor, at least partly, as long as they are in a ‘status nascendi state’. The discussion of all these effects is supported by corresponding experimental data and experiments in vitro. This review presents a complete new conception of the action mechanisms of hormones.


Corresponding author: Professor Dr. Nikola Getoff, Faculty of Life Sciences, Section Radiation Biology, Department of Nutritional Sciences, The University of Vienna, A-1090 Vienna, Althanstr. 14, UZAII, Austria, Phone: +43 (1) 4277-54966, Fax: +43 (1) 4277-54965

References

1. Getoff N, Scholes G, Weiss J. Reduction of carbon dioxide in aqueous solution under the influence of radiation. Tetrahedron Lett 1960;19:17–23.10.1016/S0040-4039(01)84080-6Search in Google Scholar

2. Getoff N, Reduction of carbon dioxide in aqueous solution under the influence of UV–light (in German). Z f Naturforsch 1962;17b:87–90.Search in Google Scholar

3. Hart EJ, Boag JW. Absorption spectrum of the hydrated electron in water and in aqueous solutions. J Am Chem Soc 1962;84: 4090–5.10.1021/ja00880a025Search in Google Scholar

4. Schulte-Frohlinde D, Eiben K. Solvated electrons in frozen solutions (in German), Z f Naturforsch 1962;17a:445–6.10.1515/zna-1962-0514Search in Google Scholar

5. Getoff N, Solar S, McCormick DB. Photoejection of electrons from flavines in polar media. Science 1978;201:616–8.10.1126/science.675244Search in Google Scholar

6. Getoff N. A review of the relationship between Q(eaq) and Q(F) of excited compounds in aqueous solution. Radiat Phys Chem 1989;34:711–9.10.1016/1359-0197(89)90083-0Search in Google Scholar

7. Getoff N. Vitamin free radicals and their anticancer actions. A brief review. J in Vivo 2009;23:599–612.Search in Google Scholar

8. Getoff N, Hartmann J, Huber JC, Quint RM. Photo-induced electron emission from 17β-estradiol and progesterone and possible biological consequences. J Photochem Photobiol B 2008;92:38–41.10.1016/j.jphotobiol.2008.04.002Search in Google Scholar

9. Getoff N, Brenn E, Hartmann J, Danielova I. Method for regeneration of hormones: 17β-estradiol, 21α–hydroxyprogesterone and corticosterone. A pathway for a possible medical application. Horm Mol Biol Clin Invest 2011;7:303–13.10.1515/HMBCI.2011.110Search in Google Scholar

10. Getoff N. UV-radiation induced electron emission by hormones. Hypothesis for specific communication-mechanisms. Radiat Phys Chem 2009;78:945–50.10.1016/j.radphyschem.2009.06.010Search in Google Scholar

11. Getoff N, Schittl H, Hartmann J, Quint RM. Electron emission from photo-excited testosterone in water-ethanol solution. J Photochem Photobiol B Biology 2009;94:179–18.10.1016/j.jphotobiol.2008.11.009Search in Google Scholar

12. Getoff N, Schittl H, Quint RM. Electron emission of phytohormone genistein. Pathway for communication and biological consequences. J Current Bioactive Compounds 2009;5:215–8.10.2174/157340709789054740Search in Google Scholar

13. Buxton GV, Greenstock CL, Helman WP, Ross AB. Critical review of rate constants for reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solution. J Phys Chem Ref Data 1988;17:513–886.10.1063/1.555805Search in Google Scholar

14. Cai Z, Li X, Katsumura Y. Interaction of hydrated electron with dietary flavonoids and phenolic acid: rate constants and transient spectra studied by pulse radiolysis. Free Rad Biolog Med 1999;27:822–9.10.1016/S0891-5849(99)00118-5Search in Google Scholar

15. Gerschpacher M, Getoff N, Hartmann J, Schittl H, Danielova I, Ying Sh, Huber JC, Quint RM. Electron emission and product analysis of estrone: progesterone interaction studied by experiments in vitro. J Gynecolog Endocrinol 2011;27:496−503.10.3109/09513590.2010.495435Search in Google Scholar PubMed PubMed Central

16. Getoff N, Gerschpacher M, Hartmann J, Huber JC, Schittl H, Quint RM. The 4-hydroxyestone: electron emission, formation of secondary metabolites and mechanism of carcinogenesis. J Photochem Photobiol B Biology 2010;98:20–4.10.1016/j.jphotobiol.2009.10.003Search in Google Scholar PubMed PubMed Central

17. Getoff N, Schittl H, Gerschpacher M, Hartmann J, Danielova I, Quint RM. The effect of progesterone on the electron emission and degradation of testosterone. J Gynecolog Endocrinol Gynecolog Endocrinol 2011;27:1077–83.10.3109/09513590.2011.569790Search in Google Scholar PubMed

18. Getoff N, Danielova I, Hartmann J, Schittl H, Gerschpacher M, Ying Sh, Quint RM, Huber JC. Metabolite formation of 17β–Hydroxyprogesterone as a consequence of eaq – emission and progesterone effect regarding cancer. In Vivo 2010;24:727–33.Search in Google Scholar

19. Getoff N, Brenn E, Ying Sh. Dopamine. Effect of concentration and pH on the electron emission. Reaction Mechanisms. In Vivo 2012;26:107–12.Search in Google Scholar

20. Getoff N, Huber C, Hartmann J, Huber JC, Quint RM. Adrenaline: communication by electron emission. Effect of concentration and temperature. Product analysis, Hormone Molec Biol Chem Invest 2010;2:249–55.10.1515/HMBCI.2010.028Search in Google Scholar

21. Minaeva VA, Minaev BF, Hovorun DM. Vibrational spectra of the steroid hormones, estradiol and estriol, calculated by density functional theory. The role of low-frequency vibrations. Ukr Biokhim Zh 2008;80:82–95.Search in Google Scholar

22. Delvin TM. Textbook of biochemistry with clinical correlations. New York, NY: Wiley-Liss, 1997.Search in Google Scholar

23. Getoff N, Hartmann J, Schittl H, Gerschpacher M, Quint RM. Photoinduced regeneration of hormones by electron transfer process: potential biological and medical consequences. Radiat Phys Chem 2011;80:890–4.10.1016/j.radphyschem.2011.04.001Search in Google Scholar PubMed PubMed Central

24. Getoff N, Walder G. Cytochrome C: concentration effect on electron emission, photodegradation and mutual interaction with vitamin C. In Vivo 2012;26:129–34.Search in Google Scholar

25. Getoff N, Steinbrecher M. New findings concerning the mutual action of hormones and receptors. In Vivo, in press.Search in Google Scholar

26. Getoff N, Schittl H, Gerschpacher M, Hartmann J, Huber JC, Quint RM. 17β–Estradiol acting as an electron-mediator. Experiments in vitro. In Vivo 2010;24:173–8.Search in Google Scholar

27. Getoff N, Schittl H, Hartmann J, Gerschpacher M, Ying Sh, Danilova I, Huber JC. Mutual interaction of 17β-estratiol and progesterone. Electron emission. Free radical effect studied by experiments in vitro. In Vivo 2010;24: 535–42.Search in Google Scholar

28. Hartmann J, Getoff N. Effect of free radicals on the biological action of genistein. In vitro and synergism with mitomycin C. Anticancer Res 2009;29:3179–84.Search in Google Scholar

Received: 2012-3-16
Accepted: 2012-7-9
Published Online: 2012-10-02
Published in Print: 2012-12-01

©2012 by Walter de Gruyter Berlin Boston

Downloaded on 27.10.2025 from https://www.degruyterbrill.com/document/doi/10.1515/hmbci-2012-0024/html
Scroll to top button