Aseptic myonecrosis following intramuscular benzathine penicllin G injection: a novel syndrome

Nicholas Ryan; Andrew Olson

doi:10.1515/dx-2016-0040

Article

Aseptic myonecrosis following intramuscular benzathine penicllin G injection: a novel syndrome

Nicholas Ryan and Andrew Olson

Published/Copyright: February 21, 2017

Published by

Become an author with De Gruyter Brill

Submit Manuscript Author Information Explore this Subject

From the journal Diagnosis Volume 4 Issue 1

Abstract

We report a novel syndrome of aseptic myonecrosis in a child occurring after intramuscular (IM) benzathine penicillin G injection for the treatment of streptococcal pharyngitis. Common side effects of IM injection, including transient injection site pain and inflammation, are common and well described. However, isolated myonecrosis following IM injection in the pediatric patient has not been previously reported. Only one similar case, following IM diclofenac injection, has been discussed in the adult literature.

Keywords: adverse event; aseptic myonecrosis; Nicolau syndrome; side effect

Corresponding author: Nicholas Ryan, DO, MS, Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN, USA, Phone: + 612-624-3113

Author contributions: Andrew Olson: Dr. Olson critically reviewed the manuscript and approved the final manuscript. Nicholas Ryan: Dr. Ryan drafted and edited the initial manuscript and approved the final manuscript. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Strieker BH, van Kasteren BJ. Diclofenac-induced Isolated myonecrosis and the Nicolau syndrome. Ann Intern Med 1992;117:1058.10.7326/0003-4819-117-12-1058_1Search in Google Scholar PubMed

2. Luton K, Garcia C, Poletti E, Koester G. Nicolau syndrome: three cases and review. Int J Dermatol 2006;45:1326–8. 4–6.10.1111/j.1365-4632.2006.02674.xSearch in Google Scholar PubMed

3. Kiliç I, Kaya F, Özdemir AT, Demirel T, Çelik I. Nicolau syndrome due to diclofenac sodium (Voltaren^®) injection: a case report. J Med Case Rep 2014;8:404.10.1186/1752-1947-8-404Search in Google Scholar PubMed PubMed Central

4. Dadaci M, Altuntas Z, Ince B, Bilgen F, Tufekci O, Poyraz N. Nicolau syndrome after intramuscular injection of non-steroidal anti-inflammatory drugs (NSAID). Bosn J Basic Med Sci 2015;15:57–60.10.17305/bjbms.2015.1.190Search in Google Scholar PubMed PubMed Central

5. Findlay AR, Goyal NA, Mozaffar T. An overview of polymyositis and dermatomyositis. Muscle Nerve 2015;51:638–56.10.1002/mus.24566Search in Google Scholar PubMed

6. Kliegman R, Behrman R, Jenson H. Nelson textbook of pediatrics, 19th ed. Vol 2. Philadelphia, PA: Elsevier, W.B. Saunders, 2015.Search in Google Scholar

7. Santos JA, Albuquerque C, Lito D, Cunha F. Benign acute childhood myositis: an alarming condition with an excellent prognosis! Am J Emerg Med 2014;32:1418–9.10.1016/j.ajem.2014.08.022Search in Google Scholar PubMed

8. Choby BA. Diagnosis and treatment of streptococcal pharyngitis. Am Fam Physician 2009;79:383–90.Search in Google Scholar

Received: 2016-10-29

Accepted: 2017-1-2

Published Online: 2017-2-21

Published in Print: 2017-3-1

You are currently not able to access this content.

Articles in the same Issue

https://doi.org/10.1515/dx-2016-0040

Keywords for this article

adverse event; aseptic myonecrosis; Nicolau syndrome; side effect