Helicobacter pylori eradication therapy for children

Kairat Rysbekov; Sagira Abrakhmanova; Rashida Satybaeva; Yekaterina Starosvetova; Almagul Kushugulova

doi:10.1515/dmpt-2024-0029

Article

Helicobacter pylori eradication therapy for children

Kairat Rysbekov , Sagira Abrakhmanova , Rashida Satybaeva , Yekaterina Starosvetova and Almagul Kushugulova

Published/Copyright: July 15, 2024

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From the journal Drug Metabolism and Personalized Therapy Volume 39 Issue 2

Abstract

Objectives

The research aims to investigate the effect of vitamin D supplementation on the efficacy of Helicobacter pylori eradication therapy and to find new drug combinations for the eradication of the bacterium.

Methods

A total of 128 children participated in the research. They were distributed under the following criteria: group A were children who tested positive for H. pylori and were treated with the standard so-called triple therapy including vitamin D; group B were children who tested positive for H. pylori and received the standard triple therapy without including vitamin D in the treatment; and group C were children who tested negative for H. pylori. After endoscopic examination, additional venous blood samples were taken from the children to determine vitamin D levels. A controlled study was carried out 45 days after the initial treatment.

Results

The overall success rate of eradication therapy was 84.1 %. In group A, the success rate of treatment was 93.5 %, contrary to group B, where the success rate was 75 %. Although there was a difference in the percentage of H. pylori eradication therapy in the main group compared to the control group, there was no significant difference in group B. The success rate of eradication is p=0.082.

Conclusions

Following the research results, the addition of vitamin D to the standard triple therapy regimen for H. pylori had no effect. It can therefore be concluded that vitamin D does not significantly increase the efficacy of eradication therapy.

Keywords: antibiotic; bacteria; plan; resistance; vitamin D

Corresponding author: Kairat Rysbekov, Department of Pediatric Diseases with Courses Cardio-Rheumatology and Gastroenterology, Astana Medical University, 49A Beibitshilik Str. 010000, Astana, Kazakhstan, E-mail: rysbekovk33@gmail.com

Research ethics: IRB Ethical approval statement. All procedures performed in the study were in accordance with the ethical standards of the Institutional Research Committee and with the 1964 Helsinki Declaration and its later amendmentsю a study was approved by the Ethics Commission of the Astana Medical University, No. 99008.
Informed consent: Informed consent was obtained from all individuals included in this study.
Author contributions: K.R., S.A., R.S., Y.S. and A.K. contributed to the design and implementation of the research, to the analysis of the results and to the writing of the manuscript. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Not applicable.
Research funding: None declared.
Data availability: The data that support the findings of this study are available on request from the corresponding author.

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Received: 2024-04-10

Accepted: 2024-06-17

Published Online: 2024-07-15

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https://doi.org/10.1515/dmpt-2024-0029

Keywords for this article

antibiotic; bacteria; plan; resistance; vitamin D