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Current developments and advancements of 3-dimensional printing in personalized medication and drug screening

  • Megha Tonk ORCID logo EMAIL logo , Vishal Gupta , Amar Dhwaj and Monika Sachdeva
Published/Copyright: September 30, 2024
Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 39 Issue 4

Abstract

Introduction

3-Dimensional printing (3DP) is an additive manufacturing (AM) technique that is expanding quickly because of its low cost and excellent efficiency. The 3D printing industry grew by 19.5 % in 2021 in spite of the COVID-19 epidemic, and by 2026, the worldwide market is expected to be valued up to 37.2 billion US dollars.

Content

Science Direct, Scopus, MEDLINE, EMBASE, PubMed, DOAJ, and other academic databases provide evidence of the increased interest in 3DP technology and innovative drug delivery approaches in recent times.

Summary

In this review four main 3DP technologies that are appropriate for pharmaceutical applications: extrusion-based, powder-based, liquid-based, and sheet lamination-based systems are discussed. This study is focused on certain 3DP technologies that may be used to create dosage forms, pharmaceutical goods, and other items with broad regulatory acceptance and technological viability for use in commercial manufacturing. It also discusses pharmaceutical applications of 3DP in drug delivery and drug screening.

Outlook

The pharmaceutical sector has seen the prospect of 3D printing in risk assessment, medical personalisation, and the manufacture of complicated dose formulas at a reasonable cost. AM has great promise to revolutionise the manufacturing and use of medicines, especially in the field of personalized medicine. The need to understand more about the potential applications of 3DP in medical and pharmacological contexts has grown over time.

Keywords: 3D printing; drug delivery; organ chip; personalized medication; polypills; self-emulsifying drug delivery system (SEDDS)
Corresponding author: Megha Tonk, Assistant Professor, Raj Kumar Goel Institute of Technology (Pharmacy), 5-Km. Stone, Delhi-Meerut Road, 201001, Ghaziabad, Uttar Pradesh, India, E-mail:

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interest: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: Not applicable.

References

1. Wohlers, T. Wohlers report 2022: 3D printing and additive manufacturing global state of the industry. Wohlers Associates; 2022. https://books.google.co.nz/books?id=CyUGzwEACAAJ.Search in Google Scholar

2. Ameta, KL, Solanki, VS, Singh, V, Devi, AP, Chundawat, RS, Haque, S. Critical appraisal and systematic review of 3D & 4D printing in sustainable and environment-friendly smart manufacturing technologies. SMT Trends 2022;34:e00481. https://doi.org/10.1016/j.susmat.2022.e00481.Search in Google Scholar

3. Chadha, U, Abrol, A, Vora, NP, Tiwari, A, Shanker, SK, Selvaraj, SK. Performance evaluation of 3D printing technologies: a review, recent advances, current challenges, and future directions. Prog Addit Manuf 2022;7:853–86. https://doi.org/10.1108/JMTM-01-2016-0002.Search in Google Scholar

4. Jakus, AE. An introduction to 3D printing—past, present, and future promise. In: 3D printing in orthopaedic surgery. Elsevier; 2019:1–15 pp.10.1016/B978-0-323-58118-9.00001-4Search in Google Scholar

5. Krishna, R, Manjaiah, M, Mohan, CB. Developments in additive manufacturing. In: Additive manufacturing. Woodhead Publishing; 2021:37–62 pp.10.1016/B978-0-12-822056-6.00002-3Search in Google Scholar

6. Liaw, CY, Guvendiren, M. Current and emerging applications of 3D printing in medicine. Biofabrication 2017;9:024102. https://doi.org/10.1088/1758-5090/aa7279.Search in Google Scholar PubMed

7. Sachs, EM, Haggerty, JS, Cima, MJ, Williams, PA, Inventors; Massachusetts Institute of Technology, Assignee. Three-dimensional printing techniques. United States patent 5204055, 1993.Search in Google Scholar

8. Parveen, S, Yadav, R, Sangal, S, Chawra, HS, Rathore, G. Recent advancement of 3D printing application in pharmaceutical industries. IJRPR 2022;3.Search in Google Scholar

9. Parhi, R. A review of three-dimensional printing for pharmaceutical applications: quality control, risk assessment and future perspectives. J Drug Deliv Sci Technol 2021;64:102571. https://doi.org/10.1016/j.jddst.2021.102571.Search in Google Scholar

10. Pund, AT, Magar, MA, Ahirrao, YO, Chaudhari, AT, Amritkar, AM. 3D Printing Technology: a customized advanced drug delivery. Asian J Pharmaceut Clin Res 2022;15:23–33. https://doi.org/10.22159/ajpcr.2022v15i8.45136.Search in Google Scholar

11. Trenfield, SJ, Awad, A, Goyanes, A, Gaisford, S, Basit, AW. 3D printing pharmaceuticals: drug development to frontline care. TIPS (Trends Pharmacol Sci) 2018;39:440–51. https://doi.org/10.1016/j.tips.2018.02.006.Search in Google Scholar PubMed

12. Dananjaya, V, Marimuthu, S, Yang, R, Grace, AN, Abeykoon, C. Synthesis, properties, applications, 3D printing and machine learning of graphene quantum dots in polymer nanocomposites. Prog Mater Sci 2024;12:101282. https://doi.org/10.1016/j.pmatsci.2024.101282.Search in Google Scholar

13. Mohapatra, S, Kar, RK, Biswal, PK, Bindhani, S. Approaches of 3D printing in current drug delivery. Sen Int 2022;3:100146. https://doi.org/10.1016/j.sintl.2021.100146.Search in Google Scholar

14. Vaz, VM, Kumar, L. 3D printing as a promising tool in personalized medicine. AAPS PharmSciTech 2021;22:1–20. https://doi.org/10.1208/s12249-020-01905-8.Search in Google Scholar PubMed PubMed Central

15. Zeeshan, F, Madheswaran, T, Pandey, M, Gorain, B. Three-dimensional (3-D) printing technology exploited for the fabrication of drug delivery systems. Curr Pharmaceut Des 2018;24:5019–28. https://doi.org/10.2174/1381612825666190101111525.Search in Google Scholar PubMed

16. Ullah, M, Wahab, A, Khan, SU, Naeem, M, ur Rehman, K, Ali, H, et al.. 3D printing technology: a new approach for the fabrication of personalized and customized pharmaceuticals. Eur Polym J 2023;195:112240. https://doi.org/10.1016/j.eurpolymj.2023.112240 Search in Google Scholar

[a] Jain, V, Haider, N, Jain, K. 3D printing in personalized drug delivery. Curr Pharmaceut Des 2018;24:5062–71. https://doi.org/10.2174/1381612825666190215122208.Search in Google Scholar PubMed

17. Park, BJ, Choi, HJ, Moon, SJ, Kim, SJ, Bajracharya, R, Min, JY, et al.. Pharmaceutical applications of 3D printing technology: current understanding and future perspectives. J Pharm Investig 2019;49:575–85.10.1007/s40005-018-00414-ySearch in Google Scholar

18. Eshkalak, SK, Ghomi, ER, Dai, Y, Choudhury, D, Ramakrishna, S. The role of three-dimensional printing in healthcare and medicine. Mater Des 2020;194:108940.10.1016/j.matdes.2020.108940Search in Google Scholar

19. Alayoubi, A, Zidan, A, Asfari, S, Ashraf, M, Sau, L, Kopcha, M. Mechanistic understanding of the performance of personalized 3D-printed cardiovascular polypills: a case study of patient-centered therapy. Int J Pharm 2022;617:121599. https://doi.org/10.1016/j.ijpharm.2022.121599.Search in Google Scholar PubMed

20. Zheng, Y, Deng, F, Wang, B, Wu, Y, Luo, Q, Zuo, X, et al.. Melt extrusion deposition (MED™) 3D printing technology–A paradigm shift in design and development of modified release drug products. Int J Pharm 2021;602:120639. https://doi.org/10.1016/j.ijpharm.2021.120639.Search in Google Scholar PubMed

21. Sen, K, Manchanda, A, Mehta, T, Ma, AW, Chaudhuri, B. Formulation design for inkjet-based 3D printed tablets. Int J Pharm 2020;584:119430. https://doi.org/10.1016/j.ijpharm.2020.119430.Search in Google Scholar PubMed

22. Sen, K, Mehta, T, Sansare, S, Sharifi, L, Ma, AW, Chaudhuri, B. Pharmaceutical applications of powder-based binder jet 3D printing process–a review. Adv Drug Deliv Rev 2021;177:113943. https://doi.org/10.1016/j.addr.2021.113943.Search in Google Scholar PubMed

23. Chang, SY, Jin, J, Yan, J, Dong, X, Chaudhuri, B, Nagapudi, K, et al.. Development of a pilot-scale HuskyJet binder jet 3D printer for additive manufacturing of pharmaceutical tablets. Int J Pharm 2021;605:120791. https://doi.org/10.1016/j.ijpharm.2021.120791.Search in Google Scholar PubMed

24. Antic, A, Zhang, J, Amini, N, Morton, DA, Hapgood, KP. Screening pharmaceutical excipient powders for use in commercial 3D binder jetting printers. Adv Powder Technol 2021;32:2469–83. https://doi.org/10.1016/j.apt.2021.05.014.Search in Google Scholar

25. Ragelle, H, Rahimian, S, Guzzi, EA, Westenskow, PD, Tibbitt, MW, Schwach, G, et al.. Additive manufacturing in drug delivery: innovative drug product design and opportunities for industrial application. Adv Drug Deliv Rev 2021;178:113990. https://doi.org/10.1016/j.addr.2021.113990.Search in Google Scholar PubMed

26. Awad, A, Fina, F, Goyanes, A, Gaisford, S, Basit, AW. Advances in powder bed fusion 3D printing in drug delivery and healthcare. Adv Drug Deliv Rev 2021;174:406–24. https://doi.org/10.1016/j.addr.2021.04.025.Search in Google Scholar PubMed

27. Gueche, YA, Sanchez-Ballester, NM, Cailleaux, S, Bataille, B, Soulairol, I. Selective laser sintering (SLS), a new chapter in the production of solid oral forms (SOFs) by 3D printing. Pharmaceutics 2021;13:1212. https://doi.org/10.3390/pharmaceutics13081212.Search in Google Scholar PubMed PubMed Central

28. Awad, A, Fina, F, Goyanes, A, Gaisford, S, Basit, AW. 3D printing: principles and pharmaceutical applications of selective laser sintering. Int J Pharm 2020;586:119594. https://doi.org/10.1016/j.ijpharm.2020.119594.Search in Google Scholar PubMed

29. Budzik, G, Tomaszewski, K, Soboń, A. Opportunities for the application of 3D printing in the critical infrastructure system. Energies 2022;15:1656. https://doi.org/10.3390/en15051656.Search in Google Scholar

30. Kam, D, Rulf, O, Reisinger, A, Lieberman, R, Magdassi, S. 3D printing by stereolithography using thermal initiators. Nat Commun 2024;15:2285. https://doi.org/10.1038/s41467-024-46532-0.Search in Google Scholar PubMed PubMed Central

31. Prabhakar, P, Sen, RK, Dwivedi, N, Khan, R, Solanki, PR, Srivastava, AK, et al.. 3D-Printed microfluidics and potential biomedical applications. FNano 2021;3:609355. https://doi.org/10.3389/fnano.2021.609355.Search in Google Scholar

32. Sundarkumar, V, Nagy, ZK, Reklaitis, GV. Small-scale continuous drug product manufacturing using dropwise additive manufacturing and three phase settling for integration with upstream drug substance production. J Pharmaceut Sci 2022;111:2330–40. https://doi.org/10.1016/j.xphs.2022.03.009.Search in Google Scholar PubMed PubMed Central

33. Wojtyłko, M, Lamprou, DA, Froelich, A, Kuczko, W, Wichniarek, R, Osmałek, T. 3D-printed solid oral dosage forms for mental and neurological disorders: recent advances and future perspectives. Expet Opin Drug Deliv 2023:1–9. https://doi.org/10.1080/17425247.2023.2292692.Search in Google Scholar PubMed

34. Khosravani, MR, Reinicke, T. On the environmental impacts of 3D printing technology. Appl Mater Today 2020;20:100689. https://doi.org/10.1016/j.apmt.2020.100689.Search in Google Scholar

35. Milián-Guimerá, C, McCabe, R, Thamdrup, LH, Ghavami, M, Boisen, A. Smart pills and drug delivery devices enabling next generation oral dosage forms. J Contr Release 2023;364:227–45. https://doi.org/10.1016/j.jconrel.2023.10.041.Search in Google Scholar PubMed

36. Tracy, T, Wu, L, Liu, X, Cheng, S, Li, X. 3D printing: innovative solutions for patients and pharmaceutical industry. Int J Pharm 2023;631:122480. https://doi.org/10.1016/j.ijpharm.2022.122480.Search in Google Scholar PubMed

37. Larush, L, Kaner, I, Fluksman, A, Tamsut, A, Pawar, AA, Lesnovski, P, et al.. 3D printing of responsive hydrogels for drug-delivery systems. J 3D Print Med 2017;1:219–29. https://doi.org/10.2217/3dp-2017-0009.Search in Google Scholar

38. Cui, M, Pan, H, Li, L, Fang, D, Sun, H, Qiao, S, et al.. Exploration and preparation of patient-specific ciprofloxacin implants drug delivery system via 3D printing technologies. J Pharmaceut Sci 2021;110:3678–89. https://doi.org/10.1016/j.xphs.2021.08.004.Search in Google Scholar PubMed

39. Içten, E, Giridhar, A, Taylor, LS, Nagy, ZK, Reklaitis, GV. Dropwise additive manufacturing of pharmaceutical products for melt-based dosage forms. J Pharmaceut Sci 2015;104:1641–9. https://doi.org/10.1002/jps.24367.Search in Google Scholar PubMed

40. Khaled, SA, Burley, JC, Alexander, MR, Yang, J, Roberts, CJ. 3D printing of tablets containing multiple drugs with defined release profiles. Int J Pharm 2015;494:643–50. https://doi.org/10.1016/j.ijpharm.2015.07.067.Search in Google Scholar PubMed

41. Pietrzak, K, Isreb, A, Alhnan, MA. A flexible-dose dispenser for immediate and extended-release 3D printed tablets. Eur J Pharm Biopharm 2015;96:380–7. https://doi.org/10.1016/j.ejpb.2015.07.027.Search in Google Scholar PubMed

42. Liaskoni, A, Wildman, RD, Roberts, CJ. 3D printed polymeric drug-eluting implants. Int J Pharm 2021;597:120330. https://doi.org/10.1016/j.ijpharm.2021.120330.Search in Google Scholar PubMed

43. Johnson, AR, Caudill, CL, Tumbleston, JR, Bloomquist, CJ, Moga, KA, Ermoshkin, A, et al.. Single-step fabrication of computationally designed microneedles by continuous liquid interface production. PLoS One 2016;11:e0162518. https://doi.org/10.1371/journal.pone.0162518.Search in Google Scholar PubMed PubMed Central

44. Yi, HG, Choi, YJ, Kang, KS, Hong, JM, Pati, RG, Park, MN, et al.. A 3D-printed local drug delivery patch for pancreatic cancer growth suppression. J Contr Release 2016;238:231–41. https://doi.org/10.1016/j.jconrel.2016.06.015.Search in Google Scholar PubMed

45. Shi, K, Tan, DK, Nokhodchi, A, Maniruzzaman, M. Drop-on-powder 3D printing of tablets with an anti-cancer drug, 5-fluorouracil. Pharmaceutics 2019;11:150. https://doi.org/10.3390/pharmaceutics11040150.Search in Google Scholar PubMed PubMed Central

46. Domínguez-Robles, J, Martin, NK, Fong, ML, Stewart, SA, Irwin, NJ, Rial-Hermida, MI, et al.. Antioxidant PLA composites containing lignin for 3D printing applications: a potential material for healthcare applications. Pharmaceutics 2019;11:165. https://doi.org/10.3390/pharmaceutics11040165.Search in Google Scholar PubMed PubMed Central

47. Isreb, A, Baj, K, Wojsz, M, Isreb, M, Peak, M, Alhnan, MA. 3D printed oral theophylline doses with innovative ‘radiator-like’design: impact of polyethylene oxide (PEO) molecular weight. Int J Pharm 2019;564:98–105. https://doi.org/10.1016/j.ijpharm.2019.04.017.Search in Google Scholar PubMed

48. Cader, HK, Rance, GA, Alexander, MR, Gonçalves, AD, Roberts, CJ, Tuck, CJ, et al.. Water-based 3D inkjet printing of an oral pharmaceutical dosage form. Int J Pharm 2019;564:359–68. https://doi.org/10.1016/j.ijpharm.2019.04.026.Search in Google Scholar PubMed

49. Goyanes, A, Buanz, AB, Hatton, GB, Gaisford, S, Basit, AW. 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur J Pharm Biopharm 2015;89:157–62. https://doi.org/10.1016/j.ejpb.2014.12.003.Search in Google Scholar PubMed

50. Tan, G, Ioannou, N, Mathew, E, Tagalakis, AD, Lamprou, DA, Yu-Wai-Man, C. 3D printing in Ophthalmology: from medical implants to personalised medicine. Int J Pharm 2022;625:122094. https://doi.org/10.1016/j.ijpharm.2022.122094.Search in Google Scholar PubMed

51. Khaled, SA, Alexander, MR, Irvine, DJ, Wildman, RD, Wallace, MJ, Sharpe, S, et al.. Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry. AAPS PharmSciTech 2018;19:3403–13. https://doi.org/10.1208/s12249-018-1107-z.Search in Google Scholar PubMed PubMed Central

52. Qian, H, Chen, D, Xu, X, Li, R, Yan, G, Fan, T. FDM 3D-printed sustained-release gastric-floating verapamil hydrochloride formulations with cylinder, capsule and hemisphere shapes, and low infill percentage. Pharmaceutics 2022;14:281. https://doi.org/10.3390/pharmaceutics14020281.Search in Google Scholar PubMed PubMed Central

53. Barber, BW, Dumont, C, Caisse, P, Simon, GP, Boyd, BJ. A 3D-printed polymer–lipid-hybrid tablet towards the development of bespoke SMEDDS formulations. Pharmaceutics 2021;13:2107. https://doi.org/10.3390/pharmaceutics13122107.Search in Google Scholar PubMed PubMed Central

54. Malebari, AM, Kara, A, Khayyat, AN, Mohammad, KA, Serrano, DR. Development of advanced 3D-printed solid dosage pediatric formulations for HIV treatment. Pharmaceuticals 2022;15:435. https://doi.org/10.3390/ph15040435.Search in Google Scholar PubMed PubMed Central

55. Olmos-Juste, R, Alonso-Lerma, B, Pérez-Jiménez, R, Gabilondo, N, Eceiza, A. 3D printed alginate-cellulose nanofibers based patches for local curcumin administration. Carbohydr Polym 2021;264:118026. https://doi.org/10.1016/j.carbpol.2021.118026.Search in Google Scholar PubMed

56. Seoane-Viaño, I, Ong, JJ, Luzardo-Álvarez, A, González-Barcia, M, Basit, AW, Otero-Espinar, FJ, et al.. 3D printed tacrolimus suppositories for the treatment of ulcerative colitis. Asian J Pharm Sci 2021;16:110–9. https://doi.org/10.1016/j.ajps.2020.06.003.Search in Google Scholar PubMed PubMed Central

57. Uddin, MJ, Scoutaris, N, Economidou, SN, Giraud, C, Chowdhry, BZ, Donnelly, RF, et al.. 3D printed microneedles for anticancer therapy of skin tumours. Inside MS C 2020;107:110248. https://doi.org/10.1016/j.msec.2019.1102488.Search in Google Scholar

58. Goto, E, Tagami, T, Ogawa, K, Ozeki, T. Fabrication of 3D-printed contact lens composed of polyethylene glycol diacrylate for controlled release of azithromycin. Biol Pharm Bull 2023;46:1461–7. https://doi.org/10.1248/bpb.b23-00443.Search in Google Scholar PubMed

59. Feng, S, Repka, MA. Future prospects including novel polymeric excipients for 3D printing of pharmaceutical and biomedical applications. In: 3D printing: emerging technologies and functionality of polymeric excipients in drug product development. Cham: Springer International Publishing; 2023:273–86 pp.10.1007/978-3-031-46015-9_11Search in Google Scholar

60. Mohammed, AA, Algahtani, MS, Ahmad, MZ, Ahmad, J, Kotta, S. 3D Printing in medicine: technology overview and drug delivery applications. Ann 3D Print Med 2021;4:100037. https://doi.org/10.1016/j.stlm.2021.100037.Search in Google Scholar

61. Seoane-Viaño, I, Otero-Espinar, FJ, Goyanes, Á. 3D printing of pharmaceutical products. In: Additive Manufacturing. Elsevier; 2021, 1:569–97 pp.10.1016/B978-0-12-818411-0.00022-7Search in Google Scholar

62. Zheng, Z, Lv, J, Yang, W, Pi, X, Lin, W, Lin, Z, et al.. Preparation and application of subdivided tablets using 3D printing for precise hospital dispensing. Eur J Pharmaceut Sci 2020;149:105293. https://doi.org/10.1016/j.ejps.2020.105293.Search in Google Scholar PubMed

63. Gao, G, Ahn, M, Cho, WW, Kim, BS, Cho, DW. 3D printing of pharmaceutical application: drug screening and drug delivery. Pharmaceutics 2021;13:1373. https://doi.org/10.3390/pharmaceutics13091373.Search in Google Scholar PubMed PubMed Central

64. Cotabarren, I, Gallo, L. 3D printing of PVA capsular devices for modified drug delivery: design and in vitro dissolution studies. Drug Dev Ind Pharm 2020;46:1416–26. https://doi.org/10.1080/03639045.2020.1791166.Search in Google Scholar PubMed

65. Patel, SK, Khoder, M, Peak, M, Alhnan, MA. Controlling drug release with additive manufacturing-based solutions. Adv Drug Deliv Rev 2021;174:369–86. https://doi.org/10.1016/j.addr.2021.04.020.Search in Google Scholar PubMed

66. Russi, L, Del Gaudio, C. 3D printed multicompartmental capsules for a progressive drug release. Ann 3D Print Med 2021;3:100026. https://doi.org/10.1016/j.stlm.2021.100026.Search in Google Scholar

67. Wallace, N, Schaffer, NE, Aleem, IS, Patel, R. 3D-printed patient-specific spine implants: a systematic review. Clin Spine Surg 2020;33:400–7. https://doi.org/10.1097/BSD.0000000000001026.Search in Google Scholar PubMed

68. Yadav, D, Garg, RK, Ahlawat, A, Chhabra, D. 3D printable biomaterials for orthopedic implants: solution for sustainable and circular economy. Resour Pol 2020;68:101767. https://doi.org/10.1016/j.resourpol.2020.101767.Search in Google Scholar

69. Wang, Y, Sun, L, Mei, Z, Zhang, F, He, M, Fletcher, C, et al.. 3D printed biodegradable implants as an individualized drug delivery system for local chemotherapy of osteosarcoma. Mater Des 2020;186:108336. https://doi.org/10.1016/j.matdes.2019.108336.Search in Google Scholar

70. Imrie, P, Jin, J. Multimaterial hydrogel 3D printing. Macromol Mater Eng 2024;309:2300272. https://doi.org/10.1002/mame.202300272.Search in Google Scholar

71. Chen, G, Xu, Y, Kwok, PC, Kang, L. Pharmaceutical applications of 3D printing. Addit Manuf 2020;34:101209. https://doi.org/10.1016/j.addma.2020.101209.Search in Google Scholar

72. Mahesh Krishna, B, Francis, LKM, Robert Singh, G, Gopichand, A. 3D printing in drug delivery and healthcare. In: Prasad, A, Kumar, A, Gupta, M, editors. Advanced materials and manufacturing techniques for biomedical applications. Hoboken, NJ: Wiley; 2023:241–74 pp. https://doi.org/10.1002/9781394166985.ch10.Search in Google Scholar

73. Bird, D, Ravindra, NM. Transdermal drug delivery and patches—an overview. Med Devices Sens 2020;3:e10069. https://doi.org/10.1002/mds3.10069.Search in Google Scholar

74. Elahpour, N, Pahlevanzadeh, F, Kharaziha, M, Bakhsheshi-Rad, HR, Ramakrishna, S, Berto, F. 3D printed microneedles for transdermal drug delivery: a brief review of two decades. Int J Pharm 2021;597:120301. https://doi.org/10.1016/j.ijpharm.2021.120301.Search in Google Scholar PubMed

75. Maurizii, G, Moroni, S, Khorshid, S, Aluigi, A, Tiboni, M, Casettari, L. 3D-printed EVA-based patches manufactured by direct powder extrusion for personalized transdermal therapies. Int J Pharm 2023;635:122720. https://doi.org/10.1016/j.ijpharm.2023.122720.Search in Google Scholar PubMed

76. Sun, X, Lv, G, Xiong, J, Zhao, J, Zhao, J, Wang, Z, et al.. Novel solid self-emulsifying drug delivery system to enhance oral bioavailability of cabazitaxel. Int J Pharm 2024;14:123899. https://doi.org/10.1016/j.ijpharm.2024.123899.Search in Google Scholar PubMed

77. Seoane-Viaño, I, Januskaite, P, Alvarez-Lorenzo, C, Basit, AW, Goyanes, A. Semi-solid extrusion 3D printing in drug delivery and biomedicine: personalised solutions for healthcare challenges. J Contr Release 2021;332:367–89. https://doi.org/10.1016/j.jconrel.2021.02.027.Search in Google Scholar PubMed

78. Vithani, K, Goyanes, A, Jannin, V, Basit, AW, Gaisford, S, Boyd, BJ. An overview of 3D printing technologies for soft materials and potential opportunities for lipid-based drug delivery systems. Pharm Res 2019;36:1–20. https://doi.org/10.1007/s11095-018-2531-1.Search in Google Scholar PubMed

79. Chatzitaki, AT, Tsongas, K, Tzimtzimis, EK, Tzetzis, D, Bouropoulos, N, Barmpalexis, P, et al.. 3D printing of patient-tailored SNEDDS-based suppositories of lidocaine. J Drug Deliv Sci Technol 2021;61:102292. https://doi.org/10.1016/j.jddst.2020.102292.Search in Google Scholar

80. Mo, X, Ouyang, L, Xiong, Z, Zhang, T. Advances in digital light processing of hydrogels. Biomed Mater 2022;17:042002. https://doi.org/10.1088/1748-605X/ac6b04.Search in Google Scholar PubMed

81. Wang, Z, Liu, L, Xiang, S, Jiang, C, Wu, W, Ruan, S, et al.. Formulation and characterization of a 3D-printed cryptotanshinone-loaded niosomal hydrogel for topical therapy of acne. AAPS PharmSciTech 2020;21:1–3. https://doi.org/10.1208/s12249-020-01677-1.Search in Google Scholar PubMed

82. Soleymani Eil Bakhtiari, S, Bakhsheshi-Rad, HR, Karbasi, S, Razzaghi, M, Tavakoli, M, Ismail, AF, et al.. 3‐dimensional printing of hydrogel‐based nanocomposites: a comprehensive review on the technology description, properties, and applications. Adv Eng Mater 2021;23:2100477. https://doi.org/10.1002/adem.202100477.Search in Google Scholar

83. Xu, C, Dai, G, Hong, Y. Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications. Acta Biomater 2019;95:50–9. https://doi.org/10.1016/j.actbio.2019.05.032.Search in Google Scholar PubMed PubMed Central

84. Kass, LE, Nguyen, J. Nanocarrier‐hydrogel composite delivery systems for precision drug release. Wires Nanomed Nanobi 2022;14:e1756. https://doi.org/10.1002/wnan.1756.Search in Google Scholar PubMed PubMed Central

85. Alqahtani, AA, Ahmed, MM, Mohammed, AA, Ahmad, J. 3D printed pharmaceutical systems for personalized treatment in metabolic syndrome. Pharmaceutics 2023;15:1152. https://doi.org/10.3390/pharmaceutics15041152.Search in Google Scholar PubMed PubMed Central

86. Webster, R, Castellano, JM, Onuma, OK. Putting polypills into practice: challenges and lessons learned. Lancet 2017;389:1066–74. https://doi.org/10.1016/S0140-6736(17)30558-5.Search in Google Scholar PubMed

87. Fernández-García, R, Prada, M, Bolás-Fernández, F, Ballesteros, MP, Serrano, DR. Oral fixed-dose combination pharmaceutical products: industrial manufacturing versus personalized 3D printing. Pharm Res 2020;37:1–22. https://doi.org/10.1007/s11095-020-02847-3.Search in Google Scholar PubMed

88. Robles-Martinez, P, Xu, X, Trenfield, SJ, Awad, A, Goyanes, A, Telford, R, et al.. 3D printing of a multi-layered polypill containing six drugs using a novel stereolithographic method. Pharmaceutics 2019;11:274. https://doi.org/10.3390/pharmaceutics11060274.Search in Google Scholar PubMed PubMed Central

89. Giri, BR, Poudel, S, Kim, DW. Cellulose and its derivatives for application in 3D printing of pharmaceuticals. J Pharm Investig 2021;51:1–22. https://doi.org/10.1007/s40005-020-00498-5.Search in Google Scholar

90. Wang, S, Chen, X, Han, X, Hong, X, Li, X, Zhang, H, et al.. A review of 3D printing technology in pharmaceutics: technology and applications, now and future. Pharmaceutics 2023;15:416. https://doi.org/10.3390/pharmaceutics15020416.Search in Google Scholar PubMed PubMed Central

91. Cavero, I, Guillon, JM, Holzgrefe, HH. Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates. Expet Opin Drug Saf 2019;18:651–77. https://doi.org/10.1080/14740338.2019.1634689.Search in Google Scholar PubMed

92. Brancato, V, Oliveira, JM, Correlo, VM, Reis, RL, Kundu, SC. Could 3D models of cancer enhance drug screening? Biomaterials 2020;232:119744. https://doi.org/10.1016/j.biomaterials.2019.119744.Search in Google Scholar PubMed

93. Dhwaj, A, Roy, N, Jaiswar, A, Prabhakar, A, Verma, D. 3D-printed impedance micropump for continuous perfusion of the sample and nutrient medium integrated with a liver-on-chip prototype. ACS Omega 2022;7:40900–10. https://doi.org/10.1021/acsomega.2c03818.Search in Google Scholar PubMed PubMed Central

94. Kassem, T, Sarkar, T, Nguyen, T, Saha, D, Ahsan, F. 3D printing in solid dosage forms and organ-on-chip applications. Biosensors 2022;12:186. https://doi.org/10.3390/bios12040186.Search in Google Scholar PubMed PubMed Central

95. Leung, CM, De Haan, P, Ronaldson-Bouchard, K, Kim, GA, Ko, J, Rho, HS, et al.. A guide to the organ-on-a-chip. Nat Rev Methods Primers 2022;2:33. https://doi.org/10.1038/s43586-022-00118-6.Search in Google Scholar

96. Sadeghzade, S, Hooshiar, MH, Akbari, H, Tajer, MH, Sahneh, KK, Ziaei, SY, et al.. Recent advances in Organ-on-a-Chip models: how precision engineering integrates cutting edge technologies in fabrication and characterization. Appl Mater Today 2024;38:102231. https://doi.org/10.1016/j.apmt.2024.102231.Search in Google Scholar

97. Bircsak, KM, DeBiasio, R, Miedel, M, Alsebahi, A, Reddinger, R, Saleh, A et al.. A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®. Toxicology 2021;450:152667. https://doi.org/10.1016/j.tox.2020.152667.Search in Google Scholar PubMed

98. Juraski, AC, Sharma, S, Sparanese, S, da Silva, VA, Wong, J, Laksman, Z, et al.. 3D bioprinting for organ and organoid models and disease modeling. Expet Opin Drug Discov 2023;18:1043–59. https://doi.org/10.1080/17460441.2023.2234280.Search in Google Scholar PubMed

99. Frankowski, J, Kurzątkowska, M, Sobczak, M, Piotrowska, U. Utilization of 3D bioprinting technology in creating human tissue and organoid models for preclinical drug research-state-of-the-art. Int J Pharm 2023;12:123313. https://doi.org/10.1016/j.ijpharm.2023.123313.Search in Google Scholar PubMed

100. Leonardo, M, Prajatelistia, E, Judawisastra, H. Alginate-based bioink for organoid 3D bioprinting: a review. Bioprinting 2022;28:e00246. https://doi.org/10.1016/j.bprint.2022.e00246.Search in Google Scholar

101. Ren, Y, Yang, X, Ma, Z, Sun, X, Zhang, Y, Li, W, et al.. Developments and opportunities for 3D bioprinted organoids. Int J Bioprinting 2021;7:364. https://doi.org/10.18063/ijb.v7i3.364.Search in Google Scholar PubMed PubMed Central

102. Vurat, MT, Ergun, C, Elçin, AE, Elçin, YM. 3D Bioprinting of tissue models with customized bioinks. In: Chun, HJ, Reis, RL, Motta, A, Khang, G, editors. Bioinspired biomaterials: advances in experimental medicine and biology. Singapore: Springer; 2020, vol 1249.10.1007/978-981-15-3258-0_5Search in Google Scholar PubMed

103. Mani, MP, Sadia, M, Jaganathan, SK, Khudzari, AZ, Supriyanto, E, Saidin, S, et al.. A review on 3D printing in tissue engineering applications. J Polym Eng 2022;42:243–65. https://doi.org/10.1515/polyeng-2021-0059.Search in Google Scholar

104. Javaid, M, Haleem, A. 3D printed tissue and organ using additive manufacturing: an overview. Clin Epidemiol Glob Health 2020;8:586–94. https://doi.org/10.1016/j.cegh.2019.12.008.Search in Google Scholar

105. Vijayavenkataraman, S. 3D bioprinting: challenges in commercialization and clinical translation. J 3D Print Med 2023;7:3DP8. https://doi.org/10.2217/3dp-2022-0026.Search in Google Scholar

106. Parhi, R, Jena, GK. An updated review on application of 3D printing in fabricating pharmaceutical dosage forms. DDTR 2022;12:1–35. https://doi.org/10.1007/s13346-021-01074-6.Search in Google Scholar PubMed

107. Warsi, MH, Yusuf, M, Al Robaian, M, Khan, M, Muheem, A, Khan, S. 3D printing methods for pharmaceutical manufacturing: opportunity and challenges. Curr Pharmaceut Des 2018;24:4949–56. https://doi.org/10.2174/1381612825666181206121701.Search in Google Scholar PubMed

108. Cui, M, Pan, H, Su, Y, Fang, D, Qiao, S, Ding, P, et al.. Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development. Acta Pharm Sin B 2021;11:2488–504. https://doi.org/10.1016/j.apsb.2021.03.015.Search in Google Scholar PubMed PubMed Central

109. Sepasgozar, SM, Shi, A, Yang, L, Shirowzhan, S, Edwards, DJ. Additive manufacturing applications for industry 4.0: a systematic critical review. Buildings 2020;10:231. https://doi.org/10.3390/buildings10120231.Search in Google Scholar

110. Brambilla, CR, Okafor-Muo, OL, Hassanin, H, ElShaer, A. 3DP printing of oral solid formulations: a systematic review. Pharmaceutics 2021;13:358. https://doi.org/10.3390/pharmaceutics13030358.Search in Google Scholar PubMed PubMed Central

111. Zema, L, Melocchi, A, Maroni, A, Gazzaniga, A. Three-dimensional printing of medicinal products and the challenge of personalized therapy. J Pharmaceut Sci 2017;106:1697–705. https://doi.org/10.1016/j.xphs.2017.03.021.Search in Google Scholar PubMed

112. Kelly, BE, Bhattacharya, I, Heidari, H, Shusteff, M, Spadaccini, CM, Taylor, HK. Volumetric additive manufacturing via tomographic reconstruction. Science 2019;363:1075–9. https://doi.org/10.1126/science.aau7114.Search in Google Scholar PubMed

113. Prendergast, ME, Burdick, JA. Recent advances in enabling technologies in 3D printing for precision medicine. Adv Mater 2020;32:1902516. https://doi.org/10.1002/adma.201902516.Search in Google Scholar PubMed

114. Li, W, Mille, LS, Robledo, JA, Uribe, T, Huerta, V, Zhang, YS. Recent advances in formulating and processing biomaterial inks for vat polymerization‐based 3D printing. Adv Healthcare Mater 2020;9:2000156. https://doi.org/10.1002/adhm.202000156.Search in Google Scholar PubMed PubMed Central

115. Varghese, R, Sood, P, Salvi, S, Karsiya, J, Kumar, D. 3D printing in the pharmaceutical sector: advances and evidences. Sens Int 2022;3:100177. https://doi.org/10.1016/j.sintl.2022.100177.Search in Google Scholar

116. Amekyeh, H, Tarlochan, F, Billa, N. Practicality of 3D printed personalized medicines in therapeutics. Front Pharmacol 2021;12:646836. https://doi.org/10.3389/fphar.2021.646836.Search in Google Scholar PubMed PubMed Central

117. Elbadawi, M, McCoubrey, LE, Gavins, FK, Ong, JJ, Goyanes, A, Gaisford, S, et al.. Harnessing artificial intelligence for the next generation of 3D printed medicines. Adv Drug Deliv Rev 2021;175:113805. https://doi.org/10.1016/j.addr.2021.05.015.Search in Google Scholar PubMed

118. Oderinde, O, Liu, S, Li, K, Kang, M, Imtiaz, H, Yao, F, et al.. Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: current progress and prospects. Polym Adv Technol 2018;29:1586–602. https://doi.org/10.1002/pat.4281.Search in Google Scholar
Received: 2024-03-28
Accepted: 2024-08-06
Published Online: 2024-09-30

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. ‘Pharmacogenetics, health and ethnicity in Latin American populations’ call for the “Dr José María Cantú Award 2024”
  4. Reviews
  5. Current developments and advancements of 3-dimensional printing in personalized medication and drug screening
  6. Status of the implementation of pharmacogenetics in clinical practice in Spain: from regional to national initiatives
  7. Minireview
  8. CYP2C19 genotype-phenotype correlation: current insights and unanswered questions
  9. Original Articles
  10. Pediatric pharmacogenetics: profiling CYP2C8 polymorphisms at King Abdulaziz University Dental Clinic
  11. Optimizing tacrolimus therapeutic drug monitoring in Tunisian kidney transplant recipients: exploring the variability in bioavailability and the correlation between pharmacokinetic parameters
  12. Efficacy and safety of a polyherbal formulation in the management of Escherichia coli urinary tract infection
  13. UHPLC-MS/MS standardized extract of Vernonia amygdalina leaf inhibits CYP2C9 and CYP3A4 activities in hepatic cells of control and streptozotocin-induced diabetic rats
https://doi.org/10.1515/dmpt-2024-0024
Keywords for this article
3D printing; drug delivery; organ chip; personalized medication; polypills; self-emulsifying drug delivery system (SEDDS)

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. ‘Pharmacogenetics, health and ethnicity in Latin American populations’ call for the “Dr José María Cantú Award 2024”
  4. Reviews
  5. Current developments and advancements of 3-dimensional printing in personalized medication and drug screening
  6. Status of the implementation of pharmacogenetics in clinical practice in Spain: from regional to national initiatives
  7. Minireview
  8. CYP2C19 genotype-phenotype correlation: current insights and unanswered questions
  9. Original Articles
  10. Pediatric pharmacogenetics: profiling CYP2C8 polymorphisms at King Abdulaziz University Dental Clinic
  11. Optimizing tacrolimus therapeutic drug monitoring in Tunisian kidney transplant recipients: exploring the variability in bioavailability and the correlation between pharmacokinetic parameters
  12. Efficacy and safety of a polyherbal formulation in the management of Escherichia coli urinary tract infection
  13. UHPLC-MS/MS standardized extract of Vernonia amygdalina leaf inhibits CYP2C9 and CYP3A4 activities in hepatic cells of control and streptozotocin-induced diabetic rats
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