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CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients

  • Malek Zihlif , Osama H. Abusara ORCID logo EMAIL logo , Walid Al-Qerem ORCID logo , Mahmood Al-Ibadah , Tareq M. Mahafza , Fatima M. Al-Akhras and Naseem T. Mahafza
Published/Copyright: May 22, 2023
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Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 38 Issue 4

Abstract

Objectives

Rhinitis is classified into several types with allergic rhinitis (AR) being the most common. AR is among the inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), in which corticosteroids are administered to overcome the decrease in cortisol production. The treatment options available for AR vary with 1st line treatment being intranasal corticosteroids (INCS). The responsiveness to corticosteroids is due to their binding to corticotropin-releasing hormone receptor-1 (CRHR1). Various studies have studied the responsiveness to corticosteroids treatment in patients with asthma and COPD in association with CRHR1 gene single nucleotide polymorphisms (SNPs).

Methods

In our study, we investigated the association of three SNPs of CRHR1 gene (rs242941, rs242940, and rs72834580) with symptoms improvement post-treatment in AR patients. Blood samples were collected from 103 patients for DNA extraction and gene sequencing. Those patients started to receive INCS for 8 weeks and their symptoms were assessed, through a questionnaire, before treatment and post-treatment to check for symptoms improvement.

Results

Our data showed that improvement of eye redness is significantly less following INCS treatment in patients with allele (C) (AOR=0.289, p-value-0.028, 95 % CI=0.096–0.873) and genotype (CC) (AOR=0.048, p-value-0.037, 95 % CI=0.003–0.832) of rs242941 SNP. There was no correlation with other genotypes, alleles, or haplotypes of the investigated SNPs.

Conclusions

Our findings show that there is no correlation between CRHR1 gene polymorphism and symptoms improvement following INCS treatment. Further studies are required to evaluate the association of INCS and symptoms improvement post-treatment with larger sample size.

Keywords: allergic rhinitis; CRHR1 ; intranasal corticosteroids
Corresponding author: Dr. Osama H. Abusara, Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O.Box 130, Amman 11733, Jordan, Phone: +96264291511, E-mail:
Malek Zihlif and Osama H. Abusara contributed equally to this work.

Funding source: Al-Zaytoonah University of Jordan

Award Identifier / Grant number: 32/11/2020-2021

Acknowledgments

We thank Dr. Wassan Jarrar at Al-Zaytoonah University of Jordan for her help in the statistical analysis part.

  1. Research funding: This project was supported by Al-Zaytoonah University of Jordan grant number (32/11/2020-2021).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The IRB at UJ has approved the study protocol [IRB No. 67/UJ/22].

  6. Data availability: All data generated or analyzed during this study are included in this published article and its supplementary information file.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/dmpt-2023-0014).

Received: 2023-02-21
Accepted: 2023-04-04
Published Online: 2023-05-22

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/dmpt-2023-0014
Keywords for this article
allergic rhinitis; CRHR1; intranasal corticosteroids

Articles in the same Issue

  1. Frontmatter
  2. Editorial
  3. Ancestromics
  4. Reviews
  5. PDE5 inhibitors: breaking new grounds in the treatment of COVID-19
  6. Phytochemical profiling and biological activities of Diplazium esculentum (Retz.) Sw.: an edible vegetable fern
  7. Original Articles
  8. Effects of CYP2D6 allelic variants on therapy with tamsulosin in patients with benign prostatic hyperplasia
  9. CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients
  10. Predictive modeling of adverse drug reactions to tamoxifen therapy for breast cancer on base of pharmacogenomic testing
  11. Pharmacogenetic aspects of efficacy and safety of methotrexate treatment in pediatric acute lymphoblastic leukemia
  12. Multifunctional analysis and antimicrobial activity of Adhatoda vasica: a traditional medicinal plant
  13. Letter to the Editor
  14. Kamini Vidrawan Ras inducing opioid dependence? – understanding the facts
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