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Novel therapeutic approaches of natural oil from black seeds and its underlying mechanisms against kidney dysfunctions in haloperidol-induced male rats

  • Jacob K. Akintunde EMAIL logo and Opeyemi K. Abubakar
Published/Copyright: April 6, 2017
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Drug Metabolism and Personalized Therapy
From the journal Drug Metabolism and Personalized Therapy Volume 32 Issue 2

Abstract

Background:

Antipsychotic drugs could be nephrotoxic in schizophrenia patients.

Methods:

The present study investigated the protective effect of oil from black seed on kidney dysfunctions using several biological approaches in adult rats. The animals were divided into six groups (n=10): normal control rats; haloperidol (HAL)-induced rats: induced rats were pre-, co- and post-treated with black seed oil (BSO), respectively, and the last group was treated with the oil only. The treatment was done through oral administration, and the experiment lasted 14 days.

Results:

Therapeutic administration of HAL to rats caused reduction in both enzymatic and non-enzymatic proteins mediated by stable OH˙ and DPPH free radicals. K+, Na+ and MDA contents as well as 51 nucleotidase, aldose-reductase activities were increased with corresponding decrease in the activity of lactate dehydrogenase (LDH) in HAL-induced toxicity rats. Contrariwise, differential treatments with BSO prevented and reversed the nephrotoxicity by depleting K+, Na+, MDA contents and aldose-reductase activity, and AMP hydrolysis with increased adenosine triphosphate (ATP) in the PMFs of rat kidney. The cytotoxicity of HAL elicited on both inner renal cortex and outer medulla was equally alleviated by combined active molecules of oil from black seed (OBS). However, pre-, co- and post-treatment demonstrate significant approaches in averting nephrotoxicity of neuroleptic drug (HAL) via several biological mechanisms.

Conclusions:

This study therefore validates the use of black seed oil as therapy particularly for individuals with renal dysfunctions.

Keywords: biological approaches; electrolytes; haloperidol; mechanisms; natural oil; nephrotoxicity

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the report for publication.

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Received: 2016-12-17
Accepted: 2017-3-7
Published Online: 2017-4-6
Published in Print: 2017-5-24

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. An update on HLA alleles associated with adverse drug reactions
  4. Original Articles
  5. Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients
  6. Novel therapeutic approaches of natural oil from black seeds and its underlying mechanisms against kidney dysfunctions in haloperidol-induced male rats
  7. Evaluation of genotype-guided acenocoumarol dosing algorithms in Russian patients
  8. Letter to the Editor
  9. Pharmacogenetics-based optimisation of atazanavir treatment: potential role of new genetic predictors
  10. Congress Report
  11. 8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016
https://doi.org/10.1515/dmpt-2016-0044
Keywords for this article
biological approaches; electrolytes; haloperidol; mechanisms; natural oil; nephrotoxicity

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. An update on HLA alleles associated with adverse drug reactions
  4. Original Articles
  5. Influence of CYP3A4 and CYP3A5 polymorphisms on tacrolimus and sirolimus exposure in stable kidney transplant recipients
  6. Novel therapeutic approaches of natural oil from black seeds and its underlying mechanisms against kidney dysfunctions in haloperidol-induced male rats
  7. Evaluation of genotype-guided acenocoumarol dosing algorithms in Russian patients
  8. Letter to the Editor
  9. Pharmacogenetics-based optimisation of atazanavir treatment: potential role of new genetic predictors
  10. Congress Report
  11. 8th Santorini Conference: Systems medicine and personalized health and therapy, Santorini, Greece, 3–5 October 2016
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