Abstract
The study of pharmacogenomics has, by harnessing sequence information from human genomes, the potential to lead to novel approaches in drug discovery, an individualized application of drug therapy, and new insights into disease prevention. For this potential to be realized results need to be interpreted to the prescriber into a format which dictates an action. This mini review briefly describes the history, the regulatory environment, opinions towards, and implementation, integration and interpretation of pharmacogenomics in the United States of America and Europe. The article discusses also how interpretation of pharmacogenomics could move forward to better implementation in health care.
Author contributions:All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership:None declared.
Honorarium: None declared.
Competing interests:The funding organization(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- In Memoriam Gérard Siest
- Reviews
- Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics)
- Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen
- Mini Reviews
- The integration and interpretation of pharmacogenomics – a comparative study between the United States of America and Europe: towards better health care
- Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches
- Original Articles
- Lack of genomic diversity in the SLC47A1 gene within the indigenous Xhosa population
- Assessment of cytochrome P450 inhibition and induction potential of lupeol and betulin in rat liver microsomes
- Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function
Articles in the same Issue
- Frontmatter
- In Memoriam Gérard Siest
- Reviews
- Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics)
- Predictive biomarkers candidates for patients with metastatic colorectal cancer treated with bevacizumab-containing regimen
- Mini Reviews
- The integration and interpretation of pharmacogenomics – a comparative study between the United States of America and Europe: towards better health care
- Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches
- Original Articles
- Lack of genomic diversity in the SLC47A1 gene within the indigenous Xhosa population
- Assessment of cytochrome P450 inhibition and induction potential of lupeol and betulin in rat liver microsomes
- Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function