Abstract
Venlafaxine (VEN) is one of the safest and most effective drugs used in the treatment of selective serotonin reuptake inhibitors-resistant depression, and thereby it is nowadays one of the most commonly prescribed antidepressants. Nevertheless, patients treated with antidepressant drugs including VEN have exhibited large inter-individual variability in drug outcomes, possibly due to the influence of genetic and nongenetic factors on the drug pharmacokinetics and/or pharmacodynamics. Among them, an increased interest has emerged over the last few years on the genetic and/or phenotypic profile for drug-metabolizing cytochrome P450 isoenzymes and drug transporters such as potential predictive pharmacokinetic-based biomarkers of the variability found in drug biodisposition and antidepressant response. The integration of some of these key therapeutic biomarkers with classic therapeutic drug monitoring constitutes a promising way to individualization of VEN’s pharmacotherapy, offering to clinicians the ability to better predict and manage pharmacological treatments to maximize the drug effectiveness. Thus, this review provides an extensive discussion of the pharmacokinetics of VEN focusing in particular on metabolism issues, without forgetting the clinically relevant sources of pharmacokinetics variability (mainly the genetic sources) and aiming on the identification of phenotypic and/or genetic biomarkers for therapy optimization.
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- Frontmatter
- Editorial
- Systems Medicine in the era of ‘Big Data’: a game-changer for Personalized Medicine?
- Reviews
- Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers
- The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
- Reviews in Population Pharmacogenomics
- Pharmacogenetics of drug metabolizing enzymes in Brazilian populations
- Original Articles
- Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors
- Lurasidone drug-drug interaction studies: a comprehensive review
- Effect of selective cyclooxygenase-2 inhibitor lumiracoxib on phenolsulfonphthalein disposition in rats
- Congress Abstracts
- 7th Santorini Conference “Biologie Prospective” Systems Medicine, Personalized Health and Therapy in collaboration with ESPT
Articles in the same Issue
- Frontmatter
- Editorial
- Systems Medicine in the era of ‘Big Data’: a game-changer for Personalized Medicine?
- Reviews
- Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers
- The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect
- Reviews in Population Pharmacogenomics
- Pharmacogenetics of drug metabolizing enzymes in Brazilian populations
- Original Articles
- Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors
- Lurasidone drug-drug interaction studies: a comprehensive review
- Effect of selective cyclooxygenase-2 inhibitor lumiracoxib on phenolsulfonphthalein disposition in rats
- Congress Abstracts
- 7th Santorini Conference “Biologie Prospective” Systems Medicine, Personalized Health and Therapy in collaboration with ESPT