Abstract
Background: The use of herbs with allopathic medicines increases the possibility of herb-drug interaction, which may either be beneficial or harmful. Therefore, the present study was undertaken to determine the interaction of glibenclamide, a sulfonylurea, with the aqueous extract of garlic (Allium sativum), an herb used widely as an antidiabetic agent.
Methods: The interaction was evaluated by an acute study, chronic study, oral glucose tolerance test, and body weight estimation in streptozotocin-induced diabetic rats. Glibenclamide was given orally at two different doses of 0.25 and 0.5 mg/kg, and A. sativum extract (ASE) was administered at the dose of 500 mg/kg. Blood glucose level and body weight estimation were carried out at various intervals.
Results: The hypoglycemic effect observed with combinations of glibenclamide and ASE was greater than either of the drug given alone. Combined treatments of glibenclamide and ASE resulted in higher increase in body weight than alone treatments.
Conclusions: We conclude that ASE shows a synergistic effect with glibenclamide. This could be important in reducing the dose of glibenclamide to achieve an enhanced therapeutic effect with minimal side effects.
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©2013 by Walter de Gruyter Berlin Boston
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- New challenges for pharmacogenomics
- Reviews in Population Pharmacogenomics
- Cytochrome P450 genetic polymorphisms of Mexican indigenous populations
- Mini Review
- Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6
- Original Articles
- Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping
- Influence of Allium sativum extract on the hypoglycemic activity of glibenclamide: an approach to possible herb-drug interaction
- A population pharmacokinetic model of remifentanil in pediatric patients using body-weight-dependent allometric exponents
- Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?
- Short Communication
- Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney
Articles in the same Issue
- Masthead
- Masthead
- Editorial
- New challenges for pharmacogenomics
- Reviews in Population Pharmacogenomics
- Cytochrome P450 genetic polymorphisms of Mexican indigenous populations
- Mini Review
- Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6
- Original Articles
- Evaluation of partial area under the concentration time curve to estimate midazolam apparent oral clearance for cytochrome P450 3A phenotyping
- Influence of Allium sativum extract on the hypoglycemic activity of glibenclamide: an approach to possible herb-drug interaction
- A population pharmacokinetic model of remifentanil in pediatric patients using body-weight-dependent allometric exponents
- Unexpected interaction between CYP3A4 and BI 11634: is BI 11634 interacting with CYP3A4 similar to nifedipine?
- Short Communication
- Caffeic acid inhibits organic anion transporters OAT1 and OAT3 in rat kidney