Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells
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Xuhui Wang
Abstract
Neuritin is a neurotrophic factor associated with neuroplasticity. Most studies on neuritin focus on the nervous system; however, there has been no comprehensive evaluation of neuritin in non-neuronal cells. In this study, we screened 11 cell lines and found that neuritin was not expressed in bone marrowderived mesenchymal stem cells (BMSCs). Neuritin-expressing BMSCs were obtained by transfection. In the neuritin-expressing BMSC model, we observed significantly greater cell migration and improved anti-senescence protection, in addition to reduced proliferation and viability. In conclusion, neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells. This study provides a theoretical basis for understanding the function of neuritin.
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Articles in the same Issue
- Transcriptional profiling of bovine muscle-derived satellite cells during differentiation in vitro by high throughput RNA sequencing
- Inhibition of CEA release from epithelial cells by lipid A of Gram-negative bacteria
- Neurotrophine-3 may contribute to neuronal differentiation of mesenchymal stem cells through the activation of the bone morphogenetic protein pathway
- In vitro and in vivo analysis of human fibroblast reprogramming and multipotency
- The pharmacological features of bilirubin: the question of the century
- Evaluation of the expressions pattern of miR-10b, 21, 200c, 373 and 520c to find the correlation between epithelial-to-mesenchymal transition and melanoma stem cell potential in isolated cancer stem cells
- Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells
- Lipoxin A4 methyl ester alleviates vascular cognition impairment by regulating the expression of proteins related to autophagy and ER stress in the rat hippocampus
- Biomedical and agricultural applications of energy dispersive X-ray spectroscopy in electron microscopy
- The effect of the bioactive sphingolipids S1P and C1P on multipotent stromal cells – new opportunities in regenerative medicine
