Electrochemical DNA-Based Biosensors: Terms and Methodology
Electrochemical DNA-Based Biosensors: Terms and Methodology
Biosensors based on deoxyribonucleic nucleic acid (DNA) are well recognized among the family of chemical sensors. With respect to the specific role of DNA in organisms, there are some remarkable specific features of DNA-based biosensors that are applied mainly to the investigation of DNA itself. These biosensors are used to determine the concentration, structure, and chemical reactivity of DNA in relation to drugs and chemicals, including pro- and antioxidants, and for the detection of specific genes or mutant genes associated with human genetic diseases and infectious agents. With electrochemical signal transducers, the main advantages of biosensors are their low cost, fast response, simple design, small dimensions, and low power requirements at their high-detection potentialities.
In 1999, the IUPAC technical report “Electrochemical Biosensors: Recommended Definitions and Classification” was published. This report did not deal extensively with DNA as the biological recognition element, but considered its use in the future. Since that time, significant progress has been achieved in the development and application of electrochemical sensors based on DNA and other nucleic acids (including aptamers and peptide nucleic acids). Yet, so far there have been no efforts at essential classification in this dynamically developing field. This project is intended to produce a critical evaluation of the terms and methodology related to DNA-based biosensors.
The project deals with the following:
DNA-based biocomponents (natural, biomimetic), including their electrochemical responses
type of interaction to be addressed (DNA hybridization, DNA-drug, interactions, aptamer-antigen interactions, etc.)
detection principles (label-free, label-based, reagentless, indicator-based, etc.)
construction of DNA biosensors and DNA chips
their specific performance criteria
This project should be valuable to academic, biomedical, environmental, and food-testing researchers, as well as to drug-developing labs and sensor producers.
For more information and content, contact the Task Group Chair Jan Labuda <jan.labuda@stuba.sk>.
www.iupac.org/projects/2006-026-1-500.html
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Articles in the same Issue
- Masthead
- From the Editor
- Contents
- Toward Global Leadership in Knowledge Sharing
- 2008–2009 Bureau Membership
- Reflections on the Position of Science in Multidisciplinary Approaches
- A Hydrocarbon to Be Proud of
- Part II: Terminology in Nuclear Processes– Misconceptions and Inaccuracies
- Proceedings of the World Chemistry Leadership Meeting
- IUPAC in Torino, Italy–Part II
- Polymer International–IUPAC Award 2008: Call for Nominations
- IUPAC InChI/InChIKey Project Joins Microsoft BioIT Alliance
- IUPAC InChI/InChIKey Project Joins Microsoft BioIT Alliance
- Chemical Heritage Foundation Names Thomas R. Tritton President
- Zafra Lerman Receives George Brown Award for International Scientific Collaboration
- In Memoriam: The Oldest Active Chemist Dies at the Age of Nearly One Hundred
- Electrochemical DNA-Based Biosensors: Terms and Methodology
- Recent Advances in Nomenclature, Properties and Units: Strategy for Promoting SC-NPU Achievements
- A Multilingual Encyclopedia of Polymer Terminology
- “Global Climate Change”– Monograph for Secondary Schools
- Recommendations for Codes of Conduct
- Provisional Recommendations
- Representation of Configuration in Coordination Polyhedra and the Extension of Current Methodology to Coordination Numbers Greater than Six (IUPAC Technical Report)
- Definitions of Terms Relating to the Structure and Processing of Sols, Gels, Networks, and Inorganic- Organic Hybrid Materials (IUPAC Recommendations 2007)
- Alcohols with Water
- Nomenclatura de Química Inorgánica
- “Photochemistry for A Better Life”
- ChemSpider and Its Expanding Web
- The Evolving Identity of Chemistry
- Heterocyclic Chemistry
- Greenhouse Gases: Mitigation and Utilization
- Emulsion Polymers
- Applied Thermodynamics
- Polar Research
- Solid State Chemistry
- Stable Isotope
- Polymer Processing
- Mark Your Calendar
- Chemistry in a Changing World – New Perspective Concerning the IUPAC Family
