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Performance Evaluation Criteria for Preparation and Measurement of Macroand Microfabricated Ion-Selective Electrodes

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Chemistry International -- Newsmagazine for IUPAC
From the journal Chemistry International -- Newsmagazine for IUPAC Volume 24 Issue 6

IUPAC Projects

Performance Evaluation Criteria for Preparation and Measurement of Macroand Microfabricated Ion-Selective Electrodes

During the past several years, the application of microfabrication technologies of practical microsensor devices has entered the field of biology and medicine and is beginning to serve as the driving force for discoveries in cell biology, neurobiology, pharmacology, and tissue engineering. In parallel, the methodology of ionophorebased liquid membrane ion-selective electrodes (ISEs) has now entered the arena of trace analysis and precision science due to the latest updated and upgraded research and development of this method. This circumstance has made it necessary to also upgrade and update the evaluation criteria for the preparation and measurements of ISEs, primarily microfabricated ISEs and potentiometric cells. This is in fact the purpose of this project.

There are more or less generally accepted evaluation criteria for ISEs. Some of those are summarized in Pure and Applied Chemistry documents (PAC 1994, 66, 2527; PAC 1995, 67, 507).

In this new document, we will deal with the specialities of macro- and microfabricated ISE sensors; standard procedures for the microfabricated devices are much more critical compared to macroelectrodes. In addition, some evaluation criteria for the micro reference electrodes are of the same importance. Items we will discuss include the following:

  • conditioning of the multilayered sensor system (sensing membrane, underlying hydrogel; and eventually biocompatible coating) before use to reach high stability readings, due to water transport through the membrane

  • conditioning overnight or storage in humid atmosphere

  • conditioning and calibration before and after the measurement

  • effect of osmotic pressure (give a procedure, how to measure)

  • shelve and use lifetime (effect of storage); estimation of the residual lifetime in vivo and in vitro

  • added-site optimization for selectivity and as requisite for Nernstian response

  • electrode construction including microfabrication, FET covered with membranes, and Ppy electrode covered with membranes

  • response time as well as detection limit

  • microfabricated inner- and outer-reference electrodes

We will correct the inconsistencies in the previous document (PAC 1994, 66, 2527) (e.g., the definition of the calibration plot, which contradicts the convention related to the determination of pH). Finally, we will discuss the latest results concerning the lower detection limit, true selectivity coefficients, and twice Nernstian slopes, etc.

For more information, contact the Task Group Chairman Yoshio Umezawa<umezawa@chem.s.u-tokyo.ac.jp>.

www.iupac.org/projects/2002/2002-003-2-500.html

Published Online: 2009-09-01
Published in Print: 2002-11

© 2014 by Walter de Gruyter GmbH & Co.

Articles in the same Issue

  1. Contents
  2. What Lies Ahead for the Union
  3. PEDECIBA–Programa de DEsarrollo de CIencias BAsicas
  4. Scientific and Technical Information
  5. Macromolecular Nomenclature and Terminolo
  6. Aligning the Revised Red and Blue Books and Preparing for IUPAC Preferred Names
  7. The Address is www.iupac.org
  8. Dana Knox Receives the Franzosini Award
  9. New SIT Software Makes Speciation Calculations Easier
  10. Recommendations for NMR Measurements of High pK Values and Equilibrium Constants in Strongly Basic Solutions
  11. Performance Evaluation Criteria for Preparation and Measurement of Macroand Microfabricated Ion-Selective Electrodes
  12. New Solubility Data Projects
  13. Concepts and Structure for Requests in Clinical Laboratories
  14. Properties and Units for Transfusion Medicine and Immunohaematology
  15. Global Use of the C-NPU Concept System for Properties in Toxicology
  16. Definitions Relating to Stereochemically Asymmetric Polymerizations (IUPAC Recommendations 2001)
  17. Potentiometric Selectivity Coefficients of Ion-Selective Electrodes
  18. Provisional Recommendations
  19. The Science of Sweeteners
  20. Ionic Poylmerization
  21. Green Chemistry in Africa
  22. Vermeer's Camera: Uncovering the Truth Behind the Masterpieces
  23. Bioinformatics 2002: North-South Networking
  24. CHEMRAWN XIV Follows Up With Green Chemistry Activities
  25. Functional π-Electron Systems
  26. Organic Synthesis
  27. Solubility Phenomena–Application for Environmental Improvement
  28. Physical Organic Chemistry
  29. 11th International Conference on Polymer Characterization (POLYCHAR-11) 6-10 January 2003, Denton, Texas, USA
  30. 6th Annual UNESCO School & IUPAC Conference on Polymer Properties 14-17 April 2003, Mpumalanga, South Africa
  31. International Symposium on Ionic Polymerization 30 June-4 July 2003, Boston, USA
  32. 22nd Discussion Conference of P.M.M. on Spectroscopy of Partially Ordered Macromolecular Systems 21–24 July 2003, Prague, Czech Republic
  33. Calendar of IUPAC Sponsored Conferences
https://doi.org/10.1515/ci.2002.24.6.19b

Articles in the same Issue

  1. Contents
  2. What Lies Ahead for the Union
  3. PEDECIBA–Programa de DEsarrollo de CIencias BAsicas
  4. Scientific and Technical Information
  5. Macromolecular Nomenclature and Terminolo
  6. Aligning the Revised Red and Blue Books and Preparing for IUPAC Preferred Names
  7. The Address is www.iupac.org
  8. Dana Knox Receives the Franzosini Award
  9. New SIT Software Makes Speciation Calculations Easier
  10. Recommendations for NMR Measurements of High pK Values and Equilibrium Constants in Strongly Basic Solutions
  11. Performance Evaluation Criteria for Preparation and Measurement of Macroand Microfabricated Ion-Selective Electrodes
  12. New Solubility Data Projects
  13. Concepts and Structure for Requests in Clinical Laboratories
  14. Properties and Units for Transfusion Medicine and Immunohaematology
  15. Global Use of the C-NPU Concept System for Properties in Toxicology
  16. Definitions Relating to Stereochemically Asymmetric Polymerizations (IUPAC Recommendations 2001)
  17. Potentiometric Selectivity Coefficients of Ion-Selective Electrodes
  18. Provisional Recommendations
  19. The Science of Sweeteners
  20. Ionic Poylmerization
  21. Green Chemistry in Africa
  22. Vermeer's Camera: Uncovering the Truth Behind the Masterpieces
  23. Bioinformatics 2002: North-South Networking
  24. CHEMRAWN XIV Follows Up With Green Chemistry Activities
  25. Functional π-Electron Systems
  26. Organic Synthesis
  27. Solubility Phenomena–Application for Environmental Improvement
  28. Physical Organic Chemistry
  29. 11th International Conference on Polymer Characterization (POLYCHAR-11) 6-10 January 2003, Denton, Texas, USA
  30. 6th Annual UNESCO School & IUPAC Conference on Polymer Properties 14-17 April 2003, Mpumalanga, South Africa
  31. International Symposium on Ionic Polymerization 30 June-4 July 2003, Boston, USA
  32. 22nd Discussion Conference of P.M.M. on Spectroscopy of Partially Ordered Macromolecular Systems 21–24 July 2003, Prague, Czech Republic
  33. Calendar of IUPAC Sponsored Conferences
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