NPU codes for characterizing subpopulations of the hematopoietic lineage, described from their Clusters of Differentiation (CD) markers
Numerous diseases are associated with alterations in peripheral blood lymphocyte subpopulations, including primary, secondary, and congenital immunodeficiency’s, autoimmune diseases, infections and cancer. Identification of lymphocyte subpopulations is necessary in these clinical conditions to establish diagnosis and as a criterion for disease progression and treatment optimization.
Prior to antigen stimulation, B- and T-lymphocytes appear morphologically similar. Therefore, no consistent method to differentiate functionally unique lymphocyte populations was present before the development of monoclonal antibodies specific to Clusters of Differentiation (CD) markers present on the lymphocyte cell surface. Today, more than 350 different CD antigens have been discovered, which identify the cell type populations and the stage of differentiation.
Currently, the NPU codes for lymphocyte subpopulations have established NPU concepts, which are based on common names, like “helper”, “memory”, “naïve” etc. However, due to a rapid discovery of new subpopulations and no concise understanding of the common names, a “helper, memory T-lymphocyte” (as shown in the example below) can potentially be defined with different sets of CD-markers.
Example:
To avoid misclassification based on different understanding of the terms for lymphocyte subpopulations, the CD nomenclature has been universally adopted by the scientific community and is officially approved by the International Union of Immunological Societies (IUIS). It has also been sanctioned by the World Health Organization (WHO). Due to the role of IFCC-IUPAC in the development of NPU terminology, this project seeks to formalize the use of the CD nomenclature as valid term reference for creating NPU codes.
For more information and comments, contact Task Group Chair Evita Maria Lindholm <Evita.Maria.Lindholm@ehelse.no>
©2022 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/
Articles in the same Issue
- Masthead - Full issue pdf
- Features
- IUPAC from A Young Chemist’s Perspective
- Artificial Intelligence and Chemistry
- Physical Organic Chemistry in the 21st Century: A Q1 Progress Report
- Hidden HERstory—Helen Stevens
- IUPAC Wire
- The International Year of Basic Sciences for Sustainable Development proclaimed by the UN for 2022
- Michael E. Jung is Awarded the 2022 IUPAC-Richter Prize
- Solvay awards €300k science prize to Katalin Karikó
- 2022 CHEMRAWN VII Prize for Green Chemistry—Call for Nominations
- Metrology in the Digital Era
- Chemistry In Japan
- Happy 100th birthday HIST!
- IUPAC Emeritus Fellows
- In memoriam
- Laudatio
- Corrigendum–Chemistry Teacher International entering its fourth year
- Project Place
- Conceptualization of definition and classification for humic substances
- NPU codes for characterizing subpopulations of the hematopoietic lineage, described from their Clusters of Differentiation (CD) markers
- Minimising Environmental Impacts of Tyre and Road Wear Particles
- Educational Workshop in Polymer Sciences 2022
- Chemistry Education and Cultural Heritage—CTI Special Issue
- Safety Training Program e-learning
- Solubility data of alkanoic acids
- Making an imPACt
- Glossary of terms relating to electronic, photonic and magnetic properties of polymers (IUPAC Recommendations 2021)
- Henry’s law constants (IUPAC Recommendations 2021)
- Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species (IUPAC Technical Report)
- Did you say PFAS ?
- IUPAC Provisional Recommendations
- Up for Discussion
- An Organizational Structure for the Future
- Conference Call
- IUPAC/CCCE 2021—Montréal, Canada
- IUPAC and IYCN: Working Together for a Globally Sustainable Future
- Environmental Chemistry and Sustainability
- CHEMRAWN XXII E-waste in Africa—a boost to take strong actions for a better future
Articles in the same Issue
- Masthead - Full issue pdf
- Features
- IUPAC from A Young Chemist’s Perspective
- Artificial Intelligence and Chemistry
- Physical Organic Chemistry in the 21st Century: A Q1 Progress Report
- Hidden HERstory—Helen Stevens
- IUPAC Wire
- The International Year of Basic Sciences for Sustainable Development proclaimed by the UN for 2022
- Michael E. Jung is Awarded the 2022 IUPAC-Richter Prize
- Solvay awards €300k science prize to Katalin Karikó
- 2022 CHEMRAWN VII Prize for Green Chemistry—Call for Nominations
- Metrology in the Digital Era
- Chemistry In Japan
- Happy 100th birthday HIST!
- IUPAC Emeritus Fellows
- In memoriam
- Laudatio
- Corrigendum–Chemistry Teacher International entering its fourth year
- Project Place
- Conceptualization of definition and classification for humic substances
- NPU codes for characterizing subpopulations of the hematopoietic lineage, described from their Clusters of Differentiation (CD) markers
- Minimising Environmental Impacts of Tyre and Road Wear Particles
- Educational Workshop in Polymer Sciences 2022
- Chemistry Education and Cultural Heritage—CTI Special Issue
- Safety Training Program e-learning
- Solubility data of alkanoic acids
- Making an imPACt
- Glossary of terms relating to electronic, photonic and magnetic properties of polymers (IUPAC Recommendations 2021)
- Henry’s law constants (IUPAC Recommendations 2021)
- Methods to evaluate the scavenging activity of antioxidants toward reactive oxygen and nitrogen species (IUPAC Technical Report)
- Did you say PFAS ?
- IUPAC Provisional Recommendations
- Up for Discussion
- An Organizational Structure for the Future
- Conference Call
- IUPAC/CCCE 2021—Montréal, Canada
- IUPAC and IYCN: Working Together for a Globally Sustainable Future
- Environmental Chemistry and Sustainability
- CHEMRAWN XXII E-waste in Africa—a boost to take strong actions for a better future
