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Glossary and tutorial of xenobiotic metabolism terms used during small molecule drug discovery and development (IUPAC Technical Report)

Published/Copyright: October 15, 2021
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Chemistry International
From the journal Chemistry International Volume 43 Issue 4

Paul Erhardt, Kenneth Bachmann, et al.

Pure and Applied Chemistry, 2021

Volume 93, Issue 3, pp. 273-403

https://doi.org/10.1515/pac-2018-0208

This project originated more than 15 years ago with the intent to produce a glossary of drug metabolism terms having definitions especially applicable for use by practicing medicinal chemists. A first-draft version underwent extensive beta-testing that, fortuitously, engaged international audiences in a wide range of disciplines involved in drug discovery and development. It became clear that the inclusion of information to enhance discussions among this mix of participants would be even more valuable. The present version retains a chemical structure theme while expanding tutorial comments that aim to bridge the various perspectives that may arise during interdisciplinary communications about a given term. This glossary is intended to be educational for early stage researchers, as well as useful for investigators at various levels who participate on today’s highly multidisciplinary, collaborative small molecule drug discovery teams.

https://iupac.org/project/2000-009-1-700

Online erschienen: 2021-10-15
Erschienen im Druck: 2021-10-01

©2021 IUPAC & De Gruyter. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. For more information, please visit: http://creativecommons.org/licenses/by-nc-nd/4.0/

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https://doi.org/10.1515/ci-2021-0419

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  5. IOCD turns 40
  6. IUPAC Top Ten Emerging Technologies in Chemistry 2021
  7. IUPAC Wire
  8. Chemistry International–Freely-Available Across the World
  9. IUPAC Announces the 2021 Top Ten Emerging Technologies in Chemistry
  10. Climate Change 2021—The Physical Science Basis
  11. 2022 IUPAC-Richter Prize—Call for Nominations
  12. Awardees of the 2021 IUPAC-Zhejiang NHU International Award for Advancements in Green Chemistry
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  14. In Memoriam: Gus Somsen
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