The role of laboratory hematology between technology and professionalism: the paradigm of basophil counting
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Francesca Tosato
Abstract
Starting from the discussion topics triggered by Hoffmann about the past and current basophil counting, a broader view of the role and future of laboratory hematology, passing through some general considerations concerning the idea of laboratory medicine in the healthcare pathway between technology and professionalism, is here provided.
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Research funding: None declared.
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Author contributions: The author has accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The author states no conflict of interest.
References
1. Hoffmann, JJML. Basophil counting in hematology analyzers: time to discontinue? Clin Chem Lab Med 2020;59:812–20 https://doi.org/10.1515/cclm-2020-1528.Search in Google Scholar
2. Plebani, M, Laposata, M, Lippi, G. Driving the route of laboratory medicine: a manifesto for the future. Intern Emerg Med 2019;14:337–40 [Epub 2019 Feb 19]. https://doi.org/10.1007/s11739-019-02053-z.Search in Google Scholar
3. Plebani, M, Laposata, M, Lippi, G. A manifesto for the future of laboratory medicine professionals. Clin Chim Acta 2019;489:49–52 [Epub 2018 Nov 13]. https://doi.org/10.1016/j.cca.2018.11.021.Search in Google Scholar
4. Plebani, M. Charting the course of medical laboratories in a changing environment. Clin Chim Acta 2002;319:87–100. https://doi.org/10.1016/s0009-8981(02)00028-1.Search in Google Scholar
5. Lippi, G, Plebani, M. Integrated diagnostics: the future of laboratory medicine? Biochem Med (Zagreb) 2020;30:010501 [Epub 2019 Dec 15]. https://doi.org/10.11613/BM.2020.010501.Search in Google Scholar PubMed PubMed Central
6. Lippi, G, Plebani, M. A modern and pragmatic definition of laboratory medicine. Clin Chem Lab Med 2020;58:1171. https://doi.org/10.1515/cclm-2020-0114.Search in Google Scholar PubMed
7. Plebani, M. The future of laboratory medicine: navigating between technology and professionalism. Clin Chim Acta 2019;498:16 [Epub 2019 Jul 26]. https://doi.org/10.1016/j.cca.2019.07.030.Search in Google Scholar PubMed
8. Greaves, RF, Bernardini, S, Ferrari, M, Fortina, P, Gouget, B, Gruson, D, et al.. Key questions about the future of laboratory medicine in the next decade of the 21st century: a report from the IFCC-Emerging Technologies Division. Clin Chim Acta 2019;495:570–89 [Epub 2019 May 28]. https://doi.org/10.1016/j.cca.2019.05.021.Search in Google Scholar PubMed
9. UNI EN ISO 15189:2013 Medical laboratories — requirements for quality and competence.Search in Google Scholar
10. Bain, BJ. Diagnosis from the blood smear. N Engl J Med 2005;353:498–507. https://doi.org/10.1056/NEJMra043442.Search in Google Scholar PubMed
11. Swerdlow, SH, Campo, E, Harris, NL, Jaffe, ES, Pileri, SA, Stein, H, et al.. Revised 4th edition of WHO classification of tumours of haematopoietic and lymphoid tissues. In: World Health Organization Classification of Tumours. Lyon, France: IARC; 2017.Search in Google Scholar
12. Pelloso, M, Zuin, S, Tosato, F, Zuin, J, Fogar, P, Piva, E, et al.. Mucopolysaccharidosis type VII diagnosed from a peripheral blood smear. Am J Hematol 2020 Aug 28. https://doi.org/10.1002/ajh.25984 [Epub ahead of print].Search in Google Scholar PubMed
13. Piva, E, Pelloso, M, Ciubotaru, D, Penello, L, Burlina, A, Plebani, M. The role of automated analyzers in detecting abnormal granulation of leucocytes in lysosomal storage diseases: Maroteaux-Lamy disease. Am J Hematol 2013;88:527 [Epub 2013 Jan 22]. https://doi.org/10.1002/ajh.23377.Search in Google Scholar PubMed
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- Home pregnancy tests: quality first
- Review
- Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders
- Opinion Papers
- Basophil counting in hematology analyzers: time to discontinue?
- The role of laboratory hematology between technology and professionalism: the paradigm of basophil counting
- Recommendations for validation testing of home pregnancy tests (HPTs) in Europe
- General Clinical Chemistry and Laboratory Medicine
- The use of preanalytical quality indicators: a Turkish preliminary survey study
- The Italian External Quality Assessment (EQA) program on urinary sediment by microscopy examination: a 20 years journey
- Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation
- Evaluation of the protein gap for detection of abnormal serum gammaglobulin level: an imperfect predictor
- Impact of routine S100B protein assay on CT scan use in children with mild traumatic brain injury
- Using machine learning to develop an autoverification system in a clinical biochemistry laboratory
- Effect of collection matrix, platelet depletion, and storage conditions on plasma extracellular vesicles and extracellular vesicle-associated miRNAs measurements
- Pneumatic tube transportation of urine samples
- Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine
- A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies
- Immunosuppressant quantification in intravenous microdialysate – towards novel quasi-continuous therapeutic drug monitoring in transplanted patients
- Reference Values and Biological Variations
- Reference intervals for venous blood gas measurement in adults
- Cardiovascular Diseases
- Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy
- Diabetes
- Evaluation of the ARKRAY HA-8190V instrument for HbA1c
- Infectious Diseases
- An original multiplex method to assess five different SARS-CoV-2 antibodies
- Evaluation of dried blood spots as alternative sampling material for serological detection of anti-SARS-CoV-2 antibodies using established ELISAs
- Variability of cycle threshold values in an external quality assessment scheme for detection of the SARS-CoV-2 virus genome by RT-PCR
- The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study
- Corrigenda
- Corrigendum to: Understanding and managing interferences in clinical laboratory assays: the role of laboratory professionals
- Corrigendum to: Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents
- Letters to the Editor
- A panhaemocytometric approach to COVID-19: a retrospective study on the importance of monocyte and neutrophil population data on Sysmex XN-series analysers
- Letter in reply to the letter to the editor of Harte JV and Mykytiv V with the title “A panhaemocytometric approach to COVID-19: a retrospective study on the importance of monocyte and neutrophil population data”
- SARS-CoV-2 serologic tests: do not forget the good laboratory practice
- Long-term kinetics of anti-SARS-CoV-2 antibodies in a cohort of 197 hospitalized and non-hospitalized COVID-19 patients
- Self-sampling at home using volumetric absorptive microsampling: coupling analytical evaluation to volunteers’ perception in the context of a large scale study
- Vortex mixing to alleviate pseudothrombocytopenia in a blood specimen with platelet satellitism and platelet clumps
- Comparative evaluation of the fully automated HemosIL® AcuStar ADAMTS13 activity assay vs. ELISA: possible interference by autoantibodies different from anti ADAMTS-13
- Significant interference on specific point-of-care glucose measurements due to high dose of intravenous vitamin C therapy in critically ill patients
- As time goes by, on that you can rely … preservation of urine samples for morphological analysis of erythrocytes and casts
- Stability of control materials for α-thalassemia immunochromatographic strip test
- Reformulated Architect® cyclosporine CMIA assay: improved imprecision, worse comparability between methods
- Urine-to-plasma contamination mimicking acute kidney injury: small drops with major consequences
- Automated Mindray CL-1200i chemiluminescent assays of renin and aldosterone for the diagnosis of primary aldosteronism
- Use of common reference intervals does not necessarily allow inter-method numerical result trending
- Reply to Dr Hawkins regarding comparability of results for monitoring
Articles in the same Issue
- Frontmatter
- Editorial
- Home pregnancy tests: quality first
- Review
- Non-invasive determination of uric acid in human saliva in the diagnosis of serious disorders
- Opinion Papers
- Basophil counting in hematology analyzers: time to discontinue?
- The role of laboratory hematology between technology and professionalism: the paradigm of basophil counting
- Recommendations for validation testing of home pregnancy tests (HPTs) in Europe
- General Clinical Chemistry and Laboratory Medicine
- The use of preanalytical quality indicators: a Turkish preliminary survey study
- The Italian External Quality Assessment (EQA) program on urinary sediment by microscopy examination: a 20 years journey
- Non-HDL-C/TG ratio indicates significant underestimation of calculated low-density lipoprotein cholesterol (LDL-C) better than TG level: a study on the reliability of mathematical formulas used for LDL-C estimation
- Evaluation of the protein gap for detection of abnormal serum gammaglobulin level: an imperfect predictor
- Impact of routine S100B protein assay on CT scan use in children with mild traumatic brain injury
- Using machine learning to develop an autoverification system in a clinical biochemistry laboratory
- Effect of collection matrix, platelet depletion, and storage conditions on plasma extracellular vesicles and extracellular vesicle-associated miRNAs measurements
- Pneumatic tube transportation of urine samples
- Evaluation of the first immunosuppressive drug assay available on a fully automated LC-MS/MS-based clinical analyzer suggests a new era in laboratory medicine
- A validated LC-MS/MS method for the simultaneous quantification of the novel combination antibiotic, ceftolozane–tazobactam, in plasma (total and unbound), CSF, urine and renal replacement therapy effluent: application to pilot pharmacokinetic studies
- Immunosuppressant quantification in intravenous microdialysate – towards novel quasi-continuous therapeutic drug monitoring in transplanted patients
- Reference Values and Biological Variations
- Reference intervals for venous blood gas measurement in adults
- Cardiovascular Diseases
- Detection and functional characterization of a novel MEF2A variation responsible for familial dilated cardiomyopathy
- Diabetes
- Evaluation of the ARKRAY HA-8190V instrument for HbA1c
- Infectious Diseases
- An original multiplex method to assess five different SARS-CoV-2 antibodies
- Evaluation of dried blood spots as alternative sampling material for serological detection of anti-SARS-CoV-2 antibodies using established ELISAs
- Variability of cycle threshold values in an external quality assessment scheme for detection of the SARS-CoV-2 virus genome by RT-PCR
- The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study
- Corrigenda
- Corrigendum to: Understanding and managing interferences in clinical laboratory assays: the role of laboratory professionals
- Corrigendum to: Age appropriate reference intervals for eight kidney function and injury markers in infants, children and adolescents
- Letters to the Editor
- A panhaemocytometric approach to COVID-19: a retrospective study on the importance of monocyte and neutrophil population data on Sysmex XN-series analysers
- Letter in reply to the letter to the editor of Harte JV and Mykytiv V with the title “A panhaemocytometric approach to COVID-19: a retrospective study on the importance of monocyte and neutrophil population data”
- SARS-CoV-2 serologic tests: do not forget the good laboratory practice
- Long-term kinetics of anti-SARS-CoV-2 antibodies in a cohort of 197 hospitalized and non-hospitalized COVID-19 patients
- Self-sampling at home using volumetric absorptive microsampling: coupling analytical evaluation to volunteers’ perception in the context of a large scale study
- Vortex mixing to alleviate pseudothrombocytopenia in a blood specimen with platelet satellitism and platelet clumps
- Comparative evaluation of the fully automated HemosIL® AcuStar ADAMTS13 activity assay vs. ELISA: possible interference by autoantibodies different from anti ADAMTS-13
- Significant interference on specific point-of-care glucose measurements due to high dose of intravenous vitamin C therapy in critically ill patients
- As time goes by, on that you can rely … preservation of urine samples for morphological analysis of erythrocytes and casts
- Stability of control materials for α-thalassemia immunochromatographic strip test
- Reformulated Architect® cyclosporine CMIA assay: improved imprecision, worse comparability between methods
- Urine-to-plasma contamination mimicking acute kidney injury: small drops with major consequences
- Automated Mindray CL-1200i chemiluminescent assays of renin and aldosterone for the diagnosis of primary aldosteronism
- Use of common reference intervals does not necessarily allow inter-method numerical result trending
- Reply to Dr Hawkins regarding comparability of results for monitoring
