Increased serum concentrations of soluble ST2 are associated with pulmonary complications and mortality in polytraumatized patients

Thomas Haider; Elisabeth Simader; Philipp Hacker; Hendrik J. Ankersmit; Thomas Heinz; Stefan Hajdu; Lukas L. Negrin

doi:10.1515/cclm-2017-0762

Article

Increased serum concentrations of soluble ST2 are associated with pulmonary complications and mortality in polytraumatized patients

Thomas Haider , Elisabeth Simader , Philipp Hacker , Hendrik J. Ankersmit , Thomas Heinz , Stefan Hajdu and Lukas L. Negrin

Published/Copyright: January 17, 2018

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From the journal Clinical Chemistry and Laboratory Medicine (CCLM) Volume 56 Issue 5

Abstract

Background:

We sought to evaluate the role of soluble ST2 (suppression of tumorigenicity) serum concentrations in polytraumatized patients and its potential role as biomarker for pulmonary complications.

Methods:

We included severely injured patients (injury severity score≥16) admitted to our level I trauma center and analyzed serum samples obtained on the day of admission and on day 2. Furthermore, patients with isolated thoracic injury and healthy probands were included and served as control groups. Serum samples were analyzed for soluble ST2 concentrations with a commercially available ELISA kit.

Results:

A total of 130 patients were included in the present study. Five patients with isolated thoracic injury and eight healthy probands were further included. Serum analyses revealed significantly elevated concentrations of soluble ST2 in polytraumatized patients compared to patients suffering from isolated thoracic trauma and healthy probands. In polytraumatized patients who developed pulmonary complications (acute respiratory distress syndrome and pneumonia) and in patients who died, significantly higher serum concentrations of soluble ST2 were found on day 2 (p<0.001). Serum concentrations of soluble ST2 on day 2 were of prognostic value to predict pulmonary complications in polytraumatized patients (area under the curve=0.720, 95% confidence interval=0.623–0.816). Concomitant thoracic trauma had no further impact on serum concentrations of soluble ST2.

Conclusions:

Serum concentrations of soluble ST2 are upregulated following polytrauma. Increased concentrations were associated with worse outcome.

Keywords: ARDS; pneumonia; polytrauma; pulmonary complications; ST2; thoracic injury

Corresponding author: Lukas L. Negrin, MD, PhD, MSc, Department of Trauma Surgery, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria

Acknowledgments

We would like to thank Claudia Gahleitner for her excellent support in statistics.

Conflict of interest statement: The authors declare no potential conflict of interest associated with the present study.
Author contributions: Design of the study: T.Ha. and L.L.N.; sample collection: L.L.N., S.H. and E.S.; conduction of experiments: T.Ha., E.S. and P.H.; preparation of the manuscript: T.Ha., T.H., H.J.A. and L.L.N.; proofreading: L.L.N., S.H., T.H. and H.J.A. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Supplemental Material:

The online version of this article offers supplementary material (https://doi.org/10.1515/cclm-2017-0762).

Received: 2017-8-26

Accepted: 2017-11-14

Published Online: 2018-1-17

Published in Print: 2018-4-25

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https://doi.org/10.1515/cclm-2017-0762

Keywords for this article

ARDS; pneumonia; polytrauma; pulmonary complications; ST2; thoracic injury

Increased serum concentrations of soluble ST2 are associated with pulmonary complications and mortality in polytraumatized patients

Article

Abstract

Background:

Methods:

Results:

Conclusions:

Acknowledgments

References

Supplemental Material:

Supplementary Material

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