Increased serum concentrations of soluble ST2 are associated with pulmonary complications and mortality in polytraumatized patients
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Thomas Haider
Abstract
Background:
We sought to evaluate the role of soluble ST2 (suppression of tumorigenicity) serum concentrations in polytraumatized patients and its potential role as biomarker for pulmonary complications.
Methods:
We included severely injured patients (injury severity score≥16) admitted to our level I trauma center and analyzed serum samples obtained on the day of admission and on day 2. Furthermore, patients with isolated thoracic injury and healthy probands were included and served as control groups. Serum samples were analyzed for soluble ST2 concentrations with a commercially available ELISA kit.
Results:
A total of 130 patients were included in the present study. Five patients with isolated thoracic injury and eight healthy probands were further included. Serum analyses revealed significantly elevated concentrations of soluble ST2 in polytraumatized patients compared to patients suffering from isolated thoracic trauma and healthy probands. In polytraumatized patients who developed pulmonary complications (acute respiratory distress syndrome and pneumonia) and in patients who died, significantly higher serum concentrations of soluble ST2 were found on day 2 (p<0.001). Serum concentrations of soluble ST2 on day 2 were of prognostic value to predict pulmonary complications in polytraumatized patients (area under the curve=0.720, 95% confidence interval=0.623–0.816). Concomitant thoracic trauma had no further impact on serum concentrations of soluble ST2.
Conclusions:
Serum concentrations of soluble ST2 are upregulated following polytrauma. Increased concentrations were associated with worse outcome.
Acknowledgments
We would like to thank Claudia Gahleitner for her excellent support in statistics.
Conflict of interest statement: The authors declare no potential conflict of interest associated with the present study.
Author contributions: Design of the study: T.Ha. and L.L.N.; sample collection: L.L.N., S.H. and E.S.; conduction of experiments: T.Ha., E.S. and P.H.; preparation of the manuscript: T.Ha., T.H., H.J.A. and L.L.N.; proofreading: L.L.N., S.H., T.H. and H.J.A. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Supplemental Material:
The online version of this article offers supplementary material (https://doi.org/10.1515/cclm-2017-0762).
©2018 Walter de Gruyter GmbH, Berlin/Boston
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- The influence of age and other biological variables on the estimation of reference limits of cardiac troponin T
- Reviews
- Prognostic and predictive value of EGFR and EGFR-ligands in blood of breast cancer patients: a systematic review
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- Opinion Paper
- Practical recommendations for managing hemolyzed samples in clinical chemistry testing
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- Non-invasive prenatal diagnosis of paternally inherited disorders from maternal plasma: detection of NF1 and CFTR mutations using droplet digital PCR
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- Precision, accuracy, cross reactivity and comparability of serum indices measurement on Abbott Architect c8000, Beckman Coulter AU5800 and Roche Cobas 6000 c501 clinical chemistry analyzers
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