Skip to main content
Article
Licensed
Unlicensed Requires Authentication

Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma

  • , , and EMAIL logo
Published/Copyright: September 12, 2019
Biomedical Engineering / Biomedizinische Technik
From the journal Biomedical Engineering / Biomedizinische Technik Volume 65 Issue 2

Abstract

Effective cancer therapy usually requires the assistance of well-designed drug carriers. In order to increase the drug accumulation to tumor tissue as well as to reduce the side effects of drug carriers, the hybrid drug delivery system (DDS) was developed by integrating folic acid (FA) and a metal-organic framework (MOF). The anticancer drug doxorubicin (DOX) was preloaded into the MOF nanoparticles during the synthesis process of the MOF nanoparticles. After surface modification with FA, the resulting FA/MOF/DOX nanoparticles were capable of serving as a biocompatible osteosarcoma targeting a DDS to enhance the chemotherapy of osteosarcoma. The dynamic light scattering method revealed that the obtained FA/MOF/DOX nanoparticles were particles with a size around 100 nm. Moreover, FA/MOF/DOX nanoparticles could enhance the delivery efficacy of DOX into MG63 (human osteosarcoma) cells as compared to FA free nanoparticles (MOF/DOX), in which a folate receptor (FR) might be involved. It was worth mentioning that in vitro [methylthio tetrazole (MTT) study in the MG63 cells] and in vivo (anticancer study in the MG63 xenograft model) assays both revealed that FA/MOF/DOX nanoparticles possessed stronger anticancer capability than free DOX or MOF/DOX nanoparticles.

Keywords: chemotherapy; chondroitin sulfate; doxorubicin; meta-organic framework; osteosarcoma

  1. Author Statement

  2. Research funding: Authors state no funding involved.

  3. Conflict of interest: Authors declare no conflict of interests.

  4. Informed consent: Informed consent is not applicable.

  5. Ethical approval: The conducted research is not related to either human or animals use.

References

[1] Zhang H, Yu S, Zhao X, Mao Z, Gao C. Stromal cell-derived factor-1α-encapsulated albumin/heparin nanoparticles for induced stem cell migration and intervertebral disc regeneration in vivo. Acta Biomater 2018;72:217–27.10.1016/j.actbio.2018.03.032Search in Google Scholar PubMed

[2] Yue J, Wang Z, Shao D, Chang Z, Hu R, Li L, et al. Cancer cell membrane-modified biodegradable mesoporous silica nanocarriers for berberine therapy of liver cancer. RSC Adv 2018;8:40288–97.10.1039/C8RA07574CSearch in Google Scholar PubMed PubMed Central

[3] Xiong H, Ni J, Jiang Z, Tian F, Zhou J, Yao J. Intracellular self-disassemble polysaccharide nanoassembly for multi-factors tumor drug resistance modulation of doxorubicin. Biomater Sci 2018;6:2527–40.10.1039/C8BM00570BSearch in Google Scholar PubMed

[4] Mastropietro DJ, Omidian H, Park K. Drug delivery applications for superporous hydrogels. Expert Opin Drug Deliv 2012;9: 71–89.10.1517/17425247.2012.641950Search in Google Scholar PubMed

[5] Valletregí M, Balas F, Arcos D. Mesoporous materials for drug delivery. Angew Chem Int Ed 2010;46:7548–58.10.1002/anie.200604488Search in Google Scholar PubMed

[6] Tang D, Zhao X, Yang T, Wang C. Paclitaxel prodrug based mixed micelles for tumor-targeted chemotherapy. RSC Adv 2018;8:380–9.10.1039/C7RA07796CSearch in Google Scholar

[7] Zhao X, Tang D, Yang T, Wang C. Facile preparation of biocompatible nanostructured lipid carrier with ultra-small size as a tumor-penetration delivery system. Colloids Surf B 2018;170:355–63.10.1016/j.colsurfb.2018.06.017Search in Google Scholar PubMed

[8] Majumder P, Bhunia S, Chaudhuri A. A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy. Chem Commun 2018;54:1489–92.10.1039/C7CC08517FSearch in Google Scholar

[9] Kushwah V, Katiyar SS, Dora CP, Agrawal Kumar A, Lamprou DA, Gupta RC, et al. Co-delivery of docetaxel and gemcitabine by anacardic acid modified self-assembled albumin nanoparticles for effective breast cancer management. Acta Biomater 2018;73:424–36.10.1016/j.actbio.2018.03.057Search in Google Scholar PubMed

[10] Wang C, Chen SQ, Yu Q, Hu FQ, Yuan H. Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells. J Mater Chem B 2017;5: 2068–73.10.1039/C6TB02826HSearch in Google Scholar

[11] Wang C, Chen SQ, Wang YX, Liu XR, Hu FQ, Sun JH, et al. Lipase-triggered water-responsive “Pandora’s Box“ for cancer therapy: toward induced neighboring effect and enhanced drug penetration. Adv Mater 2018;30:1706407.10.1002/adma.201706407Search in Google Scholar PubMed

[12] Yang RM, Fu CP, Fang JZ, Xu XD, Wei XH, Tang WJ, et al. Hyaluronan-modified superparamagnetic iron oxide nanoparticles for bimodal breast cancer imaging and photothermal therapy. Int J Nanomed 2017;12:197–206.10.2147/IJN.S121249Search in Google Scholar PubMed PubMed Central

[13] Liu J, Bao TY, Yang XY, Zhu PP, Wu LH, Sha JQ, et al. Controllable porosity conversion of metal-organic frameworks composed of natural ingredients for drug delivery. Chem Commun 2018;53:7804–7.10.1039/C7CC03673FSearch in Google Scholar

[14] Shen H, Liu J, Lei J, Ju H. A core-shell nanoparticle-peptide@metal-organic framework as pH and enzyme dual-recognition switch for stepwise-responsive imaging in living cells. Chem Commun 2018;54:9155–8.10.1039/C8CC04621BSearch in Google Scholar

[15] Pinto RV, Antunes F, Pires J, Graça V, Brandão P, Pinto ML. Vitamin B3 metal-organic frameworks as potential delivery vehicles for therapeutic nitric oxide. Acta Biomater 2017;51:66–74.10.1016/j.actbio.2017.01.039Search in Google Scholar PubMed

[16] Ling P, Qian C, Gao F, Lei J. Enzyme-immobilized metal-organic framework nanosheets as tandem catalysts for the generation of nitric oxide. Chem Commun 2018;54:11176–9.10.1039/C8CC05068FSearch in Google Scholar

[17] Behroozi F, Abdkhodaie MJ, Abandansari HS, Satarian L, Molazem M, Al-Jamal KT, et al. Engineering folate-targeting diselenide-containing triblock copolymer as a redox-responsive shell-sheddable micelle for antitumor therapy in vivo. Acta Biomater 2018;76:239–56.10.1016/j.actbio.2018.05.031Search in Google Scholar PubMed

[18] Luo X, Peng X, Hou J, Wu S, Shen J, Wang L. Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer. Int J Nanomed 2017;12:5331–43.10.2147/IJN.S137245Search in Google Scholar PubMed PubMed Central

[19] Tang D, Zhao X, Zhang L, Wang Z, Wang Z. Identification of hub genes to regulate breast cancer metastasis to brain by bioinformatics analyses. J Cell Biochem 2019;120:9522–31.10.1002/jcb.28228Search in Google Scholar PubMed

[20] Li R, Liu T, Wang K. Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy. Biomed Tech (Berl) 2017;62:67–73.10.1515/bmt-2015-0238Search in Google Scholar PubMed

[21] Jin X, Yang Q, Zhang Y. Synergistic apoptotic effects of apigenin TPGS liposomes and tyroservatide: implications for effective treatment of lung cancer. Int J Nanomed 2017;12:5109–18.10.2147/IJN.S140096Search in Google Scholar PubMed PubMed Central

[22] Lu H, Zhang H, Zhang D, Lu H, Ma D. A biocompatible reconstituted high-density lipoprotein nano-system as a probe for lung cancer detection. Med Sci Monit 2015;21:2726–33.10.12659/MSM.895255Search in Google Scholar PubMed PubMed Central

[23] Zhang M, He J, Jiang C, Zhang W, Yang Y, Wang Z, et al. Plaque-hyaluronidase-responsive high-density-lipoprotein-mimetic nanoparticles for multistage intimal-macrophage-targeted drug delivery and enhanced anti-atherosclerotic therapy. Int J Nanomed 2017;12:533–58.10.2147/IJN.S124252Search in Google Scholar PubMed PubMed Central

[24] Yi H, Qi T, Hou D, Sheng H, Tian S, Chen Y, et al. A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride. Int J Nanomed 2017;12:1731–45.10.2147/IJN.S122747Search in Google Scholar PubMed PubMed Central

[25] Jiang M, Han X, Guo W, Li W, Chen J, Ren G, et al. Star-shape paclitaxel prodrug self-assembled nanomedicine: combining high drug loading and enhanced cytotoxicity. RSC Adv 2016;6:109076–82.10.1039/C6RA23169ASearch in Google Scholar

[26] Wang C, Liu X, Chen S, Hu F, Sun J, Yuan H. Facile preparation of phospholipid–amorphous calcium carbonate hybrid nanoparticles: toward controllable burst drug release and enhanced tumor penetration. Chem Commun 2018;54:13080–3.10.1039/C8CC07694DSearch in Google Scholar

[27] Onda N, Kimura M, Yoshida T, Shibutani M. Preferential tumor cellular uptake and retention of indocyanine green for in vivo tumor imaging. Int J Nanomed 2016;139:673–82.Search in Google Scholar

[28] Zhao X, Tang D, Zuo X, Zhang T, Wang C. Identification of lncRNA-miRNA-mRNA regulatory network associated with epithelial ovarian cancer cisplatin-resistant. J Cellular Physiol 2019;234:19886–94.10.1002/jcp.28587Search in Google Scholar PubMed

[29] Baishya R, Nayak DK, Kumar D, Sinha S, Gupta A, Ganguly S, et al. Ursolic acid loaded plga nanoparticles: in vitro and in vivo evaluation to explore tumor targeting ability on B16F10 melanoma cell lines. Pharm Res 2016;33:1–13.10.1007/s11095-016-1994-1Search in Google Scholar PubMed

[30] Zhang X, Wu Y, Zhang M, Mao J, Wu Y, Zhang Y, et al. Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel. Int J Nanomed 2017;12:8779–99.10.2147/IJN.S150196Search in Google Scholar PubMed PubMed Central

[31] Liu M, Du H, Zhai G. Self-assembled nanoparticles based on chondroitin sulfate-deoxycholic acid conjugates for docetaxel delivery: effect of degree of substitution of deoxycholic acid. Colloids Surf B 2016;146:235–44.10.1016/j.colsurfb.2016.06.019Search in Google Scholar PubMed

[32] Lo YL, Wang HW, Liao ZX, Wang LF. The synthesis and comparison of chondroitin sulfate-modified PDMAEMA with chondroitin sulfate-modified PEI as a potential gene delivery vector. RSC Adv 2016;6:38209–22.10.1039/C6RA01957ASearch in Google Scholar

[33] Pal K, Sharma V, Sahoo D, Kapuria N, Koner AL. Large stokes-shifted NIR-emission from nanospace-induced aggregation of perylenemonoimide-doped polymer nanoparticles: imaging of folate receptor expression. Chem Commun 2018;54:523–6.10.1039/C7CC08404HSearch in Google Scholar

Received: 2019-03-04
Accepted: 2019-05-27
Published Online: 2019-09-12
Published in Print: 2020-04-28

©2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Computer-aided classification of small airways dysfunction using impulse oscillometric features: a children-focused review
  4. Research articles
  5. Epileptic seizure recognition using EEG wavelet decomposition based on nonlinear and statistical features with support vector machine classification
  6. Diagnosis of attention-deficit hyperactivity disorder using EOG signals: a new approach
  7. Quadriceps mechanomyography reflects muscle fatigue during electrical stimulus-sustained standing in adults with spinal cord injury – a proof of concept
  8. Mechanomyography-based assessment during repetitive sit-to-stand and stand-to-sit in two incomplete spinal cord-injured individuals
  9. Functional and radiographic evaluation of an interspinous device as an adjunct for lumbar interbody fusion procedures
  10. A robust grey wolf-based deep learning for brain tumour detection in MR images
  11. A left ventricular phantom for 3D echocardiographic twist measurements
  12. Research on elastic recoil and restoration of vessel pulsatility of Zn-Cu biodegradable coronary stents
  13. Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma
  14. Short communication
  15. Measuring lower limb circumference and volume – introduction of a novel optical 3D volumetric measurement system
https://doi.org/10.1515/bmt-2019-0056
Keywords for this article
chemotherapy; chondroitin sulfate; doxorubicin; meta-organic framework; osteosarcoma

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Computer-aided classification of small airways dysfunction using impulse oscillometric features: a children-focused review
  4. Research articles
  5. Epileptic seizure recognition using EEG wavelet decomposition based on nonlinear and statistical features with support vector machine classification
  6. Diagnosis of attention-deficit hyperactivity disorder using EOG signals: a new approach
  7. Quadriceps mechanomyography reflects muscle fatigue during electrical stimulus-sustained standing in adults with spinal cord injury – a proof of concept
  8. Mechanomyography-based assessment during repetitive sit-to-stand and stand-to-sit in two incomplete spinal cord-injured individuals
  9. Functional and radiographic evaluation of an interspinous device as an adjunct for lumbar interbody fusion procedures
  10. A robust grey wolf-based deep learning for brain tumour detection in MR images
  11. A left ventricular phantom for 3D echocardiographic twist measurements
  12. Research on elastic recoil and restoration of vessel pulsatility of Zn-Cu biodegradable coronary stents
  13. Folic acid decorated metal-organic frameworks loaded with doxorubicin for tumor-targeted chemotherapy of osteosarcoma
  14. Short communication
  15. Measuring lower limb circumference and volume – introduction of a novel optical 3D volumetric measurement system
Downloaded on 26.4.2026 from https://www.degruyterbrill.com/document/doi/10.1515/bmt-2019-0056/html?lang=en
Scroll to top button