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Hyaluronic acid-modified zirconium phosphate nanoparticles for potential lung cancer therapy

  • Ranwei Li , Tiecheng Liu and Ke Wang EMAIL logo
Published/Copyright: April 23, 2016

Abstract

Novel tumor-targeting zirconium phosphate (ZP) nanoparticles modified with hyaluronic acid (HA) were developed (HA-ZP), with the aim of combining the drug-loading property of ZP and the tumor-targeting ability of HA to construct a tumor-targeting paclitaxel (PTX) delivery system for potential lung cancer therapy. The experimental results indicated that PTX loading into the HA-ZP nanoparticles was as high as 20.36%±4.37%, which is favorable for cancer therapy. PTX-loaded HA-ZP nanoparticles increased the accumulation of PTX in A549 lung cancer cells via HA-mediated endocytosis and exhibited superior anticancer activity in vitro. In vivo anticancer efficacy assay revealed that HA-ZP nanoparticles possessed preferable anticancer abilities, which exhibited minimized toxic side effects of PTX and strong tumor-suppression potential in clinical application.

Award Identifier / Grant number: 20150101151JC

Funding statement: We greatly acknowledge the financial support from Provincial Training Program of Science and Technology for Innovative Talents of Jin (20130521002JH) and Natural Science Foundation of Jilin Province (20150101151JC).

Acknowledgments

We greatly acknowledge the financial support from Provincial Training Program of Science and Technology for Innovative Talents of Jin (20130521002JH) and Natural Science Foundation of Jilin Province (20150101151JC).

  1. Conflict of interest statement: The authors report no conflict of interests.

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Received: 2015-12-14
Accepted: 2016-3-9
Published Online: 2016-4-23
Published in Print: 2017-2-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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