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Quantitative fluorescence angiography for neurosurgical interventions

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Published/Copyright: June 1, 2013
Biomedizinische Technik/Biomedical Engineering
From the journal Biomedizinische Technik/Biomedical Engineering Volume 58 Issue 3

Abstract

Present methods for quantitative measurement of cerebral perfusion during neurosurgical operations require additional technology for measurement, data acquisition, and processing. This study used conventional fluorescence video angiography – as an established method to visualize blood flow in brain vessels – enhanced by a quantifying perfusion software tool. For these purposes, the fluorescence dye indocyanine green is given intravenously, and after activation by a near-infrared light source the fluorescence signal is recorded. Video data are analyzed by software algorithms to allow quantification of the blood flow. Additionally, perfusion is measured intraoperatively by a reference system. Furthermore, comparing reference measurements using a flow phantom were performed to verify the quantitative blood flow results of the software and to validate the software algorithm. Analysis of intraoperative video data provides characteristic biological parameters. These parameters were implemented in the special flow phantom for experimental validation of the developed software algorithms. Furthermore, various factors that influence the determination of perfusion parameters were analyzed by means of mathematical simulation. Comparing patient measurement, phantom experiment, and computer simulation under certain conditions (variable frame rate, vessel diameter, etc.), the results of the software algorithms are within the range of parameter accuracy of the reference methods. Therefore, the software algorithm for calculating cortical perfusion parameters from video data presents a helpful intraoperative tool without complex additional measurement technology.

Keywords: aneurysm clipping; blood flow velocity determination; indocyanine green; intracranial aneurysm; neurosurgery; video angiography
Corresponding author: Claudia Weichelt, Technische Universität Dresden, Institut für Biomedizinische Technik, D-01062 Dresden, Germany, Phone: +49-351-46334911, Fax: +49-351-46336026

This work was partially supported by Carl Zeiss Surgical GmbH, Oberkochen, Germany. The authors would like to thank Kai Merkewitz, Daniel Graf, and Anja Braune for their technical assistance and support in this project.

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Received: 2013-5-16
Accepted: 2013-5-17
Published Online: 2013-06-01
Published in Print: 2013-06-01

©2013 by Walter de Gruyter Berlin Boston

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorial
  4. Intraoperative optical imaging in neurosurgery
  5. Special issue articles
  6. SEP-induced activity and its thermographic cortical representation in a murine model
  7. Intraoperative optical imaging of functional brain areas for improved image-guided surgery
  8. Evaluation of the clinical practicability of intraoperative optical imaging comparing three different camera setups
  9. Assessment of visual function during brain surgery near the visual cortex by intraoperative optical imaging
  10. Evaluation of intraoperative optical imaging analysis methods by phantom and patient measurements
  11. Quantitative fluorescence angiography for neurosurgical interventions
  12. Autostereoscopic 3D visualization and image processing system for neurosurgery
  13. Research articles
  14. Evaluation of a semi-automatic segmentation algorithm in 3D intraoperative ultrasound brain angiography
  15. Recommendations for accurate numerical blood flow simulations of stented intracranial aneurysms
  16. No influence of simultaneous bone-substitute application on the success of immediately loaded dental implants: a retrospective cohort study
https://doi.org/10.1515/bmt-2012-0078
Keywords for this article
aneurysm clipping; blood flow velocity determination; indocyanine green; intracranial aneurysm; neurosurgery; video angiography

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Editorial
  4. Intraoperative optical imaging in neurosurgery
  5. Special issue articles
  6. SEP-induced activity and its thermographic cortical representation in a murine model
  7. Intraoperative optical imaging of functional brain areas for improved image-guided surgery
  8. Evaluation of the clinical practicability of intraoperative optical imaging comparing three different camera setups
  9. Assessment of visual function during brain surgery near the visual cortex by intraoperative optical imaging
  10. Evaluation of intraoperative optical imaging analysis methods by phantom and patient measurements
  11. Quantitative fluorescence angiography for neurosurgical interventions
  12. Autostereoscopic 3D visualization and image processing system for neurosurgery
  13. Research articles
  14. Evaluation of a semi-automatic segmentation algorithm in 3D intraoperative ultrasound brain angiography
  15. Recommendations for accurate numerical blood flow simulations of stented intracranial aneurysms
  16. No influence of simultaneous bone-substitute application on the success of immediately loaded dental implants: a retrospective cohort study
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