Superoxide anion and hydrogen peroxide-induced signaling and damage in angiotensin II and aldosterone action
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Nina Queisser
Abstract
The formation of reactive oxygen species (ROS) can be induced by xenobiotic substances, such as redox cycling molecules, but also by endogenous substances such as hormones and cytokines. Recent research shows the importance of ROS in cellular signaling. Here, the signaling pathways of the two blood pressure-regulating hormones angiotensin II and aldosterone are presented, focusing on both their physiological effects and the change of signaling owing to the action of increased concentrations or prolonged exposure. When present in high concentrations, both angiotensin II and aldosterone, as various other endogenous substances, activate NADPH oxidase, which produces superoxide. In this review the generation of superoxide anions and hydrogen peroxide in cells stimulated with angiotensin II or aldosterone, as well as the subsequently induced signaling processes and DNA damage is discussed.
©2010 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Guest Editorial
- Highlight: Xenobiotics and Cell Signaling
- Reviews
- An introduction to the molecular basics of aryl hydrocarbon receptor biology
- Mechanisms and cell signaling in alcoholic liver disease
- Superoxide anion and hydrogen peroxide-induced signaling and damage in angiotensin II and aldosterone action
- Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products
- Cadmium ions promote monocytic differentiation of human leukemia HL-60 cells treated with 1α,25-dihydroxyvitamin D3
- Zonation of heme synthesis enzymes in mouse liver and their regulation by β-catenin and Ha-ras
- The C2-streptavidin delivery system promotes the uptake of biotinylated molecules in macrophages and T-leukemia cells
- Short Communications
- c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy
- Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles
- Review
- Lipoprotein receptors – an evolutionarily ancient multifunctional receptor family
