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Hexose-6-phosphate dehydrogenase in the endoplasmic reticulum
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Silvia Senesi
Published/Copyright:
October 6, 2009
Abstract
Hexose-6-phosphate dehydrogenase (H6PD) is a luminal enzyme of the endoplasmic reticulum that is distinguished from cytosolic glucose-6-phosphate dehydrogenase by several features. H6PD converts glucose-6-phosphate and NADP+ to 6-phosphogluconate and NADPH, thereby catalyzing the first two reactions of the pentose-phosphate pathway. Because the endoplasmic reticulum has a separate pyridine nucleotide pool, H6PD provides NADPH for luminal reductases. One of these enzymes, 11β-hydroxysteroid dehydrogenase type 1 responsible for prereceptorial activation of glucocorticoids, has been the focus of much attention as a probable factor in the pathomechanism of several human diseases including insulin resistance and the metabolic syndrome. This review summarizes recent advances related to the functions of H6PD.
Keywords: apparent cortisone reductase deficiency; glucocorticoids; glucose-6-phosphate; 11β-hydroxysteroid dehydrogenase type 1; NADPH
Received: 2009-8-5
Accepted: 2009-9-3
Published Online: 2009-10-06
Published in Print: 2010-01-01
©2010 by Walter de Gruyter Berlin New York
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Keywords for this article
apparent cortisone reductase deficiency;
glucocorticoids;
glucose-6-phosphate;
11β-hydroxysteroid dehydrogenase type 1;
NADPH
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- A fluorescence correlation spectroscopy study of ligand interaction with cytokinin-specific binding protein from mung bean
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