Home Impacts of the gradient-index crystalline lens structure on its peripheral optical power profile
Article
Licensed
Unlicensed Requires Authentication

Impacts of the gradient-index crystalline lens structure on its peripheral optical power profile

  • Qing Li and Fengzhou Fang ORCID logo EMAIL logo
Published/Copyright: May 2, 2022
Become an author with De Gruyter Brill

Abstract

The crystalline lens makes an important contribution to the peripheral refraction of the human eye, which may affect the development and progression of myopia. However, little has been known about the peripheral optical features of the crystalline lens and its impacts on the peripheral ocular refraction. This study aims to investigate the relationship between the structural parameters of the crystalline lens and its peripheral power profile over a wide visual field. The peripheral power profile is defined with respect to the entrance and exit pupil centers along the chief rays. Analysis is performed by three-dimensional ray tracing through the gradient refractive index (GRIN) lens models built from measurement data. It has been found that the vergence of the wavefronts at the entrance and the exit pupil centers of the lens show an approximate linear correlation to each other for each field angle. The exponent parameters of the axial refractive index profile and the axial curvature profile, and the asphericity of the posterior lens surface are found to be the most influential parameters in the peripheral power profiles. The study also shows that there can be significantly different, sometimes unrealistic, power profiles in the homogeneous lens model compared with its corresponding GRIN model with the same external geometry. The theoretical findings on the peripheral lens properties provide a new perspective for both wide-field eye modelling and the design of intraocular lenses to achieve normal peripheral vision.


Corresponding author: Fengzhou Fang, Centre of Micro/Nano Manufacturing Technology (MNMT-Dublin), University College Dublin, Dublin 4, Ireland; and State Key Laboratory of Precision Measuring Technology and Instruments, Laboratory of Micro/Nano Manufacturing Technology (MNMT), Tianjin University, Tianjin 300072, China, E-mail:

Funding source: Science Foundation Ireland https://doi.10.13039/501100001602

Award Identifier / Grant number: 15/RP/B3208

Funding source: the State Administration of Foreign Experts Affairs and the Ministry of Education of China https://doi.10.13039/501100003512

Award Identifier / Grant number: B07014

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The authors would like to thank the financial support from Science Foundation Ireland under Grant number (15/RP/B3208), and the State Administration of Foreign Experts Affairs and the Ministry of Education of China (No. B07014).

  3. Conflict of interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

[1] J. Wallman, and J. Winawer, “Homeostasis of eye growth and the question of myopia,” Neuron, vol. 43, pp. 447–468, 2004. https://doi.org/10.1016/j.neuron.2004.08.008.Search in Google Scholar PubMed

[2] E. L. Smith, R. Ramamirtham, Y. Qiao-Grider, et al., “Effects of foveal ablation on emmetropization and form-deprivation myopia,” Investig. Ophthalmol. Vis. Sci., vol. 48, pp. 3914–3922, 2007. https://doi.org/10.1167/iovs.06-1264.Search in Google Scholar PubMed PubMed Central

[3] E. L. SmithIII, L.-F. Hung, and J. Huang, “Relative peripheral hyperopic defocus alters central refractive development in infant monkeys,” Vision Res., vol. 49, pp. 2386–2392, 2009. https://doi.org/10.1016/j.visres.2009.07.011.Search in Google Scholar PubMed PubMed Central

[4] D. O. Mutti, K. Zadnik, R. E. Fusaro, N. E. Friedman, R. I. Sholtz, and A. J. Adams, “Optical and structural development of the crystalline lens in childhood,” Invest. Ophthalmol. Vis. Sci., vol. 39, 120–133, 1998.Search in Google Scholar

[5] J. Rozema, S. Dankert, R. Iribarren, C. Lanca, and S.-M. Saw, “Axial growth and lens power loss at myopia onset in Singaporean children,” Investig. Ophthalmol. Vis. Sci., vol. 60, pp. 3091–3099, 2019. https://doi.org/10.1167/iovs.18-26247.Search in Google Scholar PubMed

[6] J. M. Ip, S.-M. Saw, K. A. Rose, et al., “Role of near work in myopia: findings in a sample of Australian school children,” Invest. Ophthalmol. Vis. Sci., vol. 49, pp. 2903–2910, 2008. https://doi.org/10.1167/iovs.07-0804.Search in Google Scholar PubMed

[7] H.-M. Huang, D. S.-T. Chang, and P.-C. Wu, “The association between near work activities and myopia in children—a systematic review and meta-analysis,” PLoS One, vol. 10, 2015, Art no. e0140419. https://doi.org/10.1371/journal.pone.0140419.Search in Google Scholar PubMed PubMed Central

[8] B. M. Heilman, A. Mohamed, M. Ruggeri, et al., “Age-dependence of the peripheral defocus of the isolated human crystalline lens,” Invest. Ophthalmol. Vis. Sci., vol. 62, pp. 15, 2021. https://doi.org/10.1167/iovs.62.3.15.Search in Google Scholar PubMed PubMed Central

[9] R. Navarro, “Adaptive model of the aging emmetropic eye and its changes with accommodation,” J. Vis., vol. 14, p. 21, 2014. https://doi.org/10.1167/14.13.21.Search in Google Scholar PubMed

[10] A. V. Goncharov, and C. Dainty, “Wide-field schematic eye models with gradient-index lens,” J. Opt. Soc. Am. A, vol. 24, pp. 2157–2174, 2007. https://doi.org/10.1364/josaa.24.002157.Search in Google Scholar PubMed

[11] M. Bahrami, and A. V. Goncharov, “Geometry-invariant gradient refractive index lens: analytical ray tracing,” J. Biomed. Opt., vol. 17, 2012, Art no. 055001. https://doi.org/10.1117/1.jbo.17.5.055001.Search in Google Scholar PubMed

[12] C. J. Sheil, and A. V. Goncharov, “Accommodating volume-constant age-dependent optical (AVOCADO) model of the crystalline GRIN lens,” Biomed. Opt. Express, vol. 7, pp. 1985–1999, 2016. https://doi.org/10.1364/boe.7.001985.Search in Google Scholar

[13] R. Navarro, F. Palos, and L. González, “Adaptive model of the gradient index of the human lens. I. Formulation and model of aging ex vivo lenses,” J. Opt. Soc. Am. A, vol. 24, pp. 2175–2185, 2007. https://doi.org/10.1364/josaa.24.002175.Search in Google Scholar

[14] Q. Li, and F. Z. Fang, “Physiology-like crystalline lens modelling for children,” Opt. Express, vol. 28, pp. 27155–27180, 2020. https://doi.org/10.1364/oe.402372.Search in Google Scholar

[15] K. Ishii, M. Yamanari, H. Iwata, Y. Yasuno, and T. Oshika, “Relationship between changes in crystalline lens shape and axial elongation in young children,” Invest. Ophthalmol. Vis. Sci., vol. 54, pp. 771–777, 2013. https://doi.org/10.1167/iovs.12-10105.Search in Google Scholar

[16] M. Dubbelman, and G. Van der Heijde, “The shape of the aging human lens: curvature, equivalent refractive index and the lens paradox,” Vision Res., vol. 41, pp. 1867–1877, 2001. https://doi.org/10.1016/s0042-6989(01)00057-8.Search in Google Scholar

[17] E. Martinez-Enriquez, A. de Castro, A. Mohamed, et al., “Age-related changes to the three-dimensional full shape of the isolated human crystalline lens,” Invest. Ophthalmol. Vis. Sci., vol. 61, p. 11, 2020. https://doi.org/10.1167/iovs.61.4.11.Search in Google Scholar PubMed PubMed Central

[18] A. Khan, J. M. Pope, P. K. Verkicharla, M. Suheimat, and D. A. Atchison, “Change in human lens dimensions, lens refractive index distribution and ciliary body ring diameter with accommodation,” Biomed. Opt. Express, vol. 9, pp. 1272–1282, 2018. https://doi.org/10.1364/boe.9.001272.Search in Google Scholar

[19] E. Kreyszig, Differential Geometry, New York, Dover Publications, 1991.Search in Google Scholar

[20] L. N. Thibos, W. Wheeler, and D. Horner, “Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error,” Optom. Vis. Sci., vol. 74, pp. 367–375, 1997. https://doi.org/10.1097/00006324-199706000-00019.Search in Google Scholar PubMed

[21] G. Dai, Wavefront Optics for Vision Correction, Washington, SPIE Press, 2008.10.1117/3.769212Search in Google Scholar

[22] T. Liu, and L. N. Thibos, “Interaction of axial and oblique astigmatism in theoretical and physical eye models,” J. Opt. Soc. Am. A, vol. 33, pp. 1723–1734, 2016. https://doi.org/10.1364/josaa.33.001723.Search in Google Scholar

[23] S.-M. Li, N. Wang, Y. Zhou, et al., “Paraxial schematic eye models for 7-and 14-year-old Chinese children,” Invest. Ophthalmol. Vis. Sci., vol. 56, pp. 3577–3583, 2015. https://doi.org/10.1167/iovs.15-16428.Search in Google Scholar PubMed

[24] Q. Li, and F. Z. Fang, “Retinal contour modelling to reproduce two-dimensional peripheral spherical equivalent refraction,” Biomed. Opt. Express, vol. 12, pp. 3948–3964, 2021. https://doi.org/10.1364/boe.426413.Search in Google Scholar

[25] J. Birkenfeld, A. de Castro, and S. Marcos, “Astigmatism of the ex vivo human lens: surface and gradient refractive index age-dependent contributions,” Investig. Ophthalmol. Vis. Sci., vol. 56, pp. 5067–5073, 2015. https://doi.org/10.1167/iovs.15-16484.Search in Google Scholar PubMed

Received: 2022-01-19
Accepted: 2022-04-10
Published Online: 2022-05-02
Published in Print: 2022-06-27

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 17.9.2025 from https://www.degruyterbrill.com/document/doi/10.1515/aot-2022-0003/pdf?lang=en
Scroll to top button