Motion-tracking technique in unrestrained small-animal single-photon emission computed tomography
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Andrew G. Weisenberger
,
Seungjoon Lee
Abstract
Medical researchers have used structural and functional imaging techniques to study various neurological phenomena. Humans are typically conscious for both structural and functional neuroimaging studies. The use of functional neuroimaging techniques in mouse-based animal models is typically accomplished with restrained or anesthetized mice. A system was developed to perform functional imaging with single-photon emission computed tomography of awake mice to avoid the confounding influences of anesthesia or physical restraint. This review article provides an overview of the technique and how it is presently being used. The system is designed for brain imaging and uses infrared reflectors to track the head position as a function of time. The detected photons are acquired in list mode and are time-stamped. The position of the rotating gamma camera is also recorded as a function of time. These three sets of data are integrated together in an iterative image reconstruction program that performs motion compensation. The successful performance of the system is demonstrated in moving phantom and awake animal studies. The system and methodology has the potential of being a powerful tool in behavioral neuroimaging studies involving awake, unrestrained mice.
©2011 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Guest Editorial
- The emerging discipline of behavioral neuroimaging
- Special Issue: Behavioral Neuroimaging
- Cognition in action: imaging brain/body dynamics in mobile humans
- Neuroimaging for drug addiction and related behaviors
- Pharmacological challenge and synaptic response – assessing dopaminergic function in the rat striatum with small animal single-photon emission computed tomography (SPECT) and positron emission tomography (PET)
- Integrating PET with behavioral neuroscience using RatCAP tomography
- Motion-tracking technique in unrestrained small-animal single-photon emission computed tomography
- Functional magnetic resonance imaging in awake animals
- Manganese enhanced MRI (MEMRI): neurophysiological applications
- Optical detection of brain function: simultaneous imaging of cerebral vascular response, tissue metabolism, and cellular activity in vivo
