Home Medicine Risk assessment for preeclampsia in women with gestational diabetes mellitus
Article
Licensed
Unlicensed Requires Authentication

Risk assessment for preeclampsia in women with gestational diabetes mellitus

  • Chadakarn Phaloprakarn and Siriwan Tangjitgamol
Published/Copyright: July 10, 2009
Journal of Perinatal Medicine
From the journal Volume 37 Issue 6

Abstract

Aim: To develop a clinical model to assess the risk of preeclampsia in women with gestational diabetes mellitus (GDM).

Methods: We studied clinical characteristics of 813 consecutive women who had GDM between January 2003 and February 2008 at our institution. The clinical features which were significantly associated with preeclampsia by multiple logistic regression analysis were integrated into a risk model. The diagnostic performance of this model was then evaluated from a receiver-operating characteristic (ROC) curve analysis.

Results: A total of 78 women with GDM (9.6%) developed preeclampsia. In a multivariable analysis, first-trimester BMI ≥27 kg/m2 (P<0.001), GDM diagnosed within 20 weeks of gestation (P<0.001), and poor glycemic control (P<0.001) were associated with preeclampsia. These three factors were incorporated into a risk-scoring model which ranged from 0 to 3 points. At the optimal cut-off score of ≥2, the sensitivity, specificity, and area under the curve (AUC) for preeclampsia were high at 76.9% [95% confidence interval (CI) 69.0–85.2], 92.8% (95% CI 85.9–98.1), and 0.849 (95% CI 0.792–0.905), respectively.

Conclusion: A model based on clinical data yielded predicted the development of preeclampsia in women with GDM.

Keywords: Clinical model; gestational diabetes mellitus (GDM); preeclampsia; risk assessment
Corresponding author: Chadakarn Phaloprakarn, MD Department of Obstetrics and Gynecology Bangkok Metropolitan Administration Medical College and Vajira Hospital 681 Samsen Road Dusit District Bangkok 10300 Thailand Tel.: +66 2244 3414 Fax: +66 2243 7907
Received: 2008-10-13
Revised: 2009-4-30
Accepted: 2009-5-4
Published Online: 2009-07-10
Published Online: 2009-07-10
Published in Print: 2009-11-01

©2009 by Walter de Gruyter Berlin New York

Articles in the same Issue

  1. Expert panel recommendation
  2. Delivery mode for the extremely premature fetus: a statement of the prematurity working group of the World Association of Perinatal Medicine
  3. Review articles
  4. The infant incubator in the neonatal intensive care unit: unresolved issues and future developments
  5. Survival and major disability rate in infant born at 22–25 weeks of gestation
  6. Original articles – Obstetrics
  7. Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers
  8. Risk assessment for preeclampsia in women with gestational diabetes mellitus
  9. Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
  10. Maternal serum adiponectin multimers in gestational diabetes
  11. The effect of maternal obesity on the course of labor
  12. Decreased placental oxygenation capacity in pre-eclampsia: clinical application of a novel index of placental function preformed at the time of delivery
  13. Utility of two-dimensional echocardiography in pregnancy and post-partum period and impact on management in an inner city hospital
  14. A new obstetrical polyurethane versus stainless steel forceps: a comparison of forces generated to the base of the fetal skull during simulated deliveries
  15. Original article – Fetus
  16. Nuchal translucency and lymphatic system maldevelopment
  17. Orginal articles – Newborn
  18. Indicators of compliance for developmental follow-up of infants discharged from a regional NICU
  19. Disparity in circulating adiponectin multimers between term and preterm infants
  20. Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction
  21. The clinical outcomes of late preterm infants: a multi-center survey of Zhejiang, China
  22. Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter-related sepsis
  23. Short communications
  24. Serum proinflammatory cytokine – interleukin-8 as possible infection site marker in preterm deliveries
  25. Obstetric outcomes of low-risk labors at ‘Japanese tatami’ mat delivery room: a preliminary study
  26. Letters to the Editor
  27. Diagnosis and treatment of maternal acute myeloid leukemia during pregnancy imitating HELLP syndrome
  28. Vanishing nuchal translucency syndrome
  29. Congenital cataract with de novo balanced reciprocal t(3;13) (q23;q12) translocation in a newborn
  30. Breast feeding as human and divine nourishment
  31. Obituary
  32. Emile Papiernik will stay alive in our thoughts
  33. Congress Calendar
  34. Congress Calendar
  35. Index Volume 37 (2009)
  36. Index Volume 37 (2009) - Contents
  37. Index - Subjects
  38. Index - Subjects
  39. Index - Authors
  40. Index - Authors
  41. Acknowledgement
  42. Acknowledgement
https://doi.org/10.1515/JPM.2009.108
Keywords for this article
Clinical model; gestational diabetes mellitus (GDM); preeclampsia; risk assessment

Articles in the same Issue

  1. Expert panel recommendation
  2. Delivery mode for the extremely premature fetus: a statement of the prematurity working group of the World Association of Perinatal Medicine
  3. Review articles
  4. The infant incubator in the neonatal intensive care unit: unresolved issues and future developments
  5. Survival and major disability rate in infant born at 22–25 weeks of gestation
  6. Original articles – Obstetrics
  7. Gene expression profiling of maternal blood in early onset severe preeclampsia: identification of novel biomarkers
  8. Risk assessment for preeclampsia in women with gestational diabetes mellitus
  9. Maternal serum adiponectin multimers in patients with a small-for-gestational-age newborn
  10. Maternal serum adiponectin multimers in gestational diabetes
  11. The effect of maternal obesity on the course of labor
  12. Decreased placental oxygenation capacity in pre-eclampsia: clinical application of a novel index of placental function preformed at the time of delivery
  13. Utility of two-dimensional echocardiography in pregnancy and post-partum period and impact on management in an inner city hospital
  14. A new obstetrical polyurethane versus stainless steel forceps: a comparison of forces generated to the base of the fetal skull during simulated deliveries
  15. Original article – Fetus
  16. Nuchal translucency and lymphatic system maldevelopment
  17. Orginal articles – Newborn
  18. Indicators of compliance for developmental follow-up of infants discharged from a regional NICU
  19. Disparity in circulating adiponectin multimers between term and preterm infants
  20. Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction
  21. The clinical outcomes of late preterm infants: a multi-center survey of Zhejiang, China
  22. Early enteral feeding in conservatively managed stage II necrotizing enterocolitis is associated with a reduced risk of catheter-related sepsis
  23. Short communications
  24. Serum proinflammatory cytokine – interleukin-8 as possible infection site marker in preterm deliveries
  25. Obstetric outcomes of low-risk labors at ‘Japanese tatami’ mat delivery room: a preliminary study
  26. Letters to the Editor
  27. Diagnosis and treatment of maternal acute myeloid leukemia during pregnancy imitating HELLP syndrome
  28. Vanishing nuchal translucency syndrome
  29. Congenital cataract with de novo balanced reciprocal t(3;13) (q23;q12) translocation in a newborn
  30. Breast feeding as human and divine nourishment
  31. Obituary
  32. Emile Papiernik will stay alive in our thoughts
  33. Congress Calendar
  34. Congress Calendar
  35. Index Volume 37 (2009)
  36. Index Volume 37 (2009) - Contents
  37. Index - Subjects
  38. Index - Subjects
  39. Index - Authors
  40. Index - Authors
  41. Acknowledgement
  42. Acknowledgement
Sign up now to receive a 20% welcome discount
Institutional Access
How does access work?
Have an idea on how to improve our website?
Please write us.
© 2026 De Gruyter Brill
Downloaded on 26.2.2026 from https://www.degruyterbrill.com/document/doi/10.1515/JPM.2009.108/html
Scroll to top button