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Milk iron content in breast-feeding mothers after administration of intravenous iron sucrose complex

  • Christian Breymann , Bettina von Seefried , Michele Stahel , Peter Geisser and Camillo Canclini
Published/Copyright: March 7, 2007
Journal of Perinatal Medicine
From the journal Volume 35 Issue 2

Abstract

Objective: To study the transfer of parenteral iron sucrose into maternal milk in the postpartum period.

Study design: Ten healthy lactating mothers with functional iron deficiency 2–3 days after delivery received 100 mg intravenous iron sucrose and were observed together with a control group (n=5) without iron treatment during four days. Milk samples were taken before the treatment and every day afterwards.

Results: Mean milk iron levels at baseline were 0.43 and 0.46 mg/kg in the treatment and control group and decreased until the end of observation in both groups by 0.11 mg/kg. No significant difference between the groups was found on any study day as well as in the mean change from baseline over all four days.

Conclusion: We could not show transfer of iron-sucorose into maternal milk for the given dosage. Since parenteral iron sucrose is widely used in obstetrics, the results provide information about safety of parenteral iron sucrose in the lactation period. The findings are also in agreement with other reports on active biological mammary gland regulation of milk iron concentration.

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Corresponding author: PD Dr. Christian Breymann Lecturer Head of research unit FetoMaternal Hematology Clinic of Obstetrics Department of Obstetrics and Gynecology University Hospital Zurich Frauenklinikstr. 10 CH-8091 Zürich, Switzerland Tel.: +41-01-255 11 11 Fax: +41-01-255 44 30

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Published Online: 2007-03-07
Published in Print: 2007-04-01

©2007 by Walter de Gruyter Berlin New York

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