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Factors associated with hypospadias in Asian newborn babies

  • Jin Ho Chong , Chee Keong Wee , Selina Kah Ying Ho and Daisy Kwai Lin Chan
Published/Copyright: December 1, 2006

Abstract

Aims: Previous studies reported an increasing temporal trend of hypospadias and a significant association with poor intrauterine growth. It remains unclear whether the association relates to birth weight, degree of prematurity or intra-uterine growth. The objective was to study the incidence of hypospadias and to examine the association with various risk factors.

Methods: A retrospective case-control study was carried out of infants admitted to a neonatal unit from January 1st, 1999 to December 31st, 2005.

Results: Of 6538 male live births, 27 (0.41%) infants had hypospadias. Incidence increased from 2.85 per thousand in 1999 to 6.89 per thousand in 2005. Hypospadias occurred significantly more frequently in babies born small for gestational age (SGA), in very low birth weight (VLBW) infants, those born preterm and to mothers with preeclampsia (PET). Logistic regression revealed that VLBW (OR 14.12, CI 5.48–36.39), maternal PET (OR 3.90, CI 1.50–10.14) and SGA (OR 3.23, CI 1.25–8.37) as independent risk factors.

Conclusions: Hypospadias is associated with VLBW, maternal PET and poor intra-uterine growth, but not with preterm birth. A rising trend in the incidence of hypospadias was noted in our population of Asian babies, suggesting a universal phenomenon.

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Corresponding author: Dr Selina Kah Ying Ho Department of Neonatal and Developmental Medicine Singapore General Hospital Outram Road Singapore 169608

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Published Online: 2006-12-01
Published in Print: 2006-12-01

©2006 by Walter de Gruyter Berlin New York

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  10. Postnatal growth failure in preterm infants: ascertainment and relation to long-term outcome
  11. Impact of breast-feeding on psychomotor and neuropsychological development in children of diabetic mothers: role of the late neonatal period
  12. Factors associated with hypospadias in Asian newborn babies
  13. Spontaneous dichorionic triamniotic triplet pregnancy affected by TTTS: follow-up from diagnosis to three months of extrauterine life
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  15. Reply
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  18. Errata
  19. Congress Calendar
  20. Index Volume 34 (2006)
  21. Index - Subjects
  22. Index - Authors
  23. Acknowledgement
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