The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy
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Ahmet Kale
Abstract
Objective: The purpose of this study was to evaluate the levels of amino-terminal probrain natriuretic peptide (Nt pro-BNP) in preeclampsia in comparison with normotensive pregnancy.
Materials and methods: Women with preeclampsia (proteinuria ≥300 mg/24 h and at least two readings of systolic blood pressure ≥140 mm Hg and diastolic blood pressure ≥90 mm Hg) (n=32 mild preeclampsia and n=8 severe preeclampsia) were compared with normotensive women (n=40). Serum Nt pro-BNP was measured using an electrochemiluminescence immunoassay (ECLIA) method (Nt pro-BNP, Roche) with a Roche modular analytics E170 immunoassay analyzer. Statistical analysis was carried out by the Student t-test, and a P value of <0.05 was accepted as statistically significant.
Results: The median serum Nt pro-BNP was 430±28.91 pg/mL in preeclampsia. The levels of serum Nt pro-BNP were 74±16.82 pg/mL in normotensive pregnant women (P<0.001) and significantly higher in women with preeclampsia (P<0.001).
Conclusion: The higher levels of serum Nt pro-BNP in preeclamptic women may be an indicator of high left-ventricular filling pressure, and indicate left-ventricular diastolic dysfunction.
References
1 Fleming SM, L O'Byrne, H Grimes, KM Daly, JJ Morrison: Cardiac troponin I in pre-eclampsia and gestational hypertension. Br J Obstet Gynaecol107 (2000) 1417Search in Google Scholar
2 Fleming SM, L O'Byrne, H Grimes, KM Daly, JJ Morrison: Amino-terminal pro-brain natriuretic peptide in normal and hypertensive pregnancy. Hypertens Pregnancy20 (2001) 169Search in Google Scholar
3 Furuhashi N, H Kimura, H Nagae, A Yajima, C Kimura, T Saito: Brain natriuretic peptide and atrial natriuretic peptide levels in normal pregnancy and preeclampsia. Gynecol Obstet Invest38 (1994) 73Search in Google Scholar
4 Hunt PJ, AM Richards, MG Nicholls, TG Yandle, RN Doughty, EA Espiner: Immunoreactive amino-terminal pro-brain natriuretic peptide: a new marker of cardiac impairment. Clin Endocrinol47 (1997) 287Search in Google Scholar
5 Itoh H, N Sagawa, M Takahide, M Mukoyama, K Nakao, H Imura: Plasma brain natriuretic peptide level in pregnant women with pregnancy-induced hypertension. Obstet Gynecol82 (1993) 71Search in Google Scholar
6 Kaaja RJ, MP Moore, TG Yandle, O Ylikorkala, CM Frampton, MG Nicholls: Blood pressure and vasoactive hormones in mild preeclampsia and normal pregnancy. Hypertens Pregnancy18 (1999) 173Search in Google Scholar
7 Kuzniar J, A Piela, A Skret: Left ventricular function in preeclamptic patients: an echocardiographic study. Am J Obstet Gynecol146 (1983) 400Search in Google Scholar
8 Lang RM, G Pridjian, T Feldman, A Neumann, M Lindheimer, KM Borow: Left ventricular mechanics in pre-eclampsia. Am Heart J121 (1991) 1768Search in Google Scholar
9 Mair J: Role of cardiac natriuretic peptide testing in heart failure. Clin Chem48 (2002) 97710.1093/clinchem/48.7.977Search in Google Scholar
10 McLaughlin MK, JM Roberts: Hemodynamic changes. In: Lindheimer ML, JM Roberts, FG Cunningham (eds): Chesley's Hypertensive Diseases in Pregnancy. 2nd Edition. Appleton & Lange, Stamford, CT 1999 p 69Search in Google Scholar
11 Mukoyama M, Nakao K, Hosoda K, Suga S, Saito Y, Ogawa Y, Shirakami G, Jougasaki M, Obata K, Yasue H: Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest87 (1991) 1402Search in Google Scholar
12 National High Blood Pressure Education Program: Working Group report on high blood pressure in pregnancy. Am J Obstet Gynecol 51 (2000) 18310.1016/S0002-9378(00)40820-3Search in Google Scholar
13 Omland T, A Aakvaag, VVS Bonarjee, K Caidahl, R Terje Lie, DWT Nilsen, JA Sundsfjord, K Dickstein: Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long term survival after acute myocardial infarction. Circulation93 (1996) 1963Search in Google Scholar
14 Richards AM, MG Nicholls, TG Yandle, C Frampton, EA Espiner, JG Turner, RC Buttimore, JG Lainchbury, JM Elliott, H Ikram, IG Crozier, DW Smyth: Plasma N-terminal pro-brain natriuretic peptide and adrenomedullin. New neurohormonal predictors of left ventricular function and prognosis after myocardial infarction. Circulation97 (1998) 1921Search in Google Scholar
15 Teng YC, XW Tang, QD Lin, YX Wu, XI Song: Relationship between left ventricular diastolic function and plasma brain natriuretic peptide concentration during severe pregnancy-induced hypertension syndrome. Zhonghua Yi Xue Za Zhi 83 (2003) 662Search in Google Scholar
16 Valli N, A Gobinet, L Bordenave: Review of 10 years of the clinical use of brain natriuretic peptide in cardiology. J Lab Clin Med134 (1999) 437Search in Google Scholar
©2005 by Walter de Gruyter Berlin New York
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Articles in the same Issue
- Declining fertility in the developed world and high maternal mortality in developing countries – how do we respond?
- Maternal obesity and complications during pregnancy
- Cesarean section upon request: is it appropriate for everybody?
- Reply to: Cesarean section upon request: is it appropriate for everybody?
- Characteristics of mothers who delivered the heaviest, average-weight, and lightest triplet sets
- Gestational age-specific distribution of twin birth weight discordance
- The comparison of amino-terminal probrain natriuretic peptide levels in preeclampsia and normotensive pregnancy
- Optimal timing for postprandial glucose measurement in pregnant women with diabetes and a non-diabetic pregnant population evaluated by the Continuous Glucose Monitoring System (CGMS®)
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- The association of birthweight with maternal and cord serum and amniotic fluid growth hormone and insulin levels, and with neonatal and maternal factors in pregnant women who delivered at term
- Amniotic fluid lamellar body counts for the determination of fetal lung maturity: an update
- Comparison of clinical criteria with echocardiographic findings in diagnosing PDA in preterm infants
- Sudden infant death syndrome “gray zone” disclosed only by a study of the brain stem on serial sections
- Incidence and diagnosis of unilateral arterial cerebral infarction in newborn infants
- Non-hydropic intrauterine fetal death more than 5 months after primary parvovirus B19 infection
- A new syndrome of myopathy with muscle spindle excess*
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