Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes
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R. G. King
Abstract
The aim of this study was to compare glucose transport and utilization in human placentae from pregnancies affected by insulin-treated GDM with and without macrosomia, and from non-diabetic control pregnancies.
Placental lobules were perfused for 4 h. Maternal D-glucose concentration was 4, 8, 16, or 24 mM while the fetal D-glucose was maintained at 3mM. [14]C-D-glucose and [3]H-L-glucose were infused into the maternal circulation. Radioactivity, D-glucose and L-lactate levels were measured in the fetal and maternal effluent perfusates.
Glucose uptake from the maternal perfusate, and transfer to the fetal effluent were not significantly different between groups. Insulin-treated GDM group without macrosomia had reduced glucose utilization compared to the control group while the insulin-treated GDM group with macrosomia did not. Lactate release into the fetal effluent was significantly reduced in both insulintreated GDM groups compared to the control group.
In conclusion, placental glucose utilization is different between insulin-treated GDM placentae with and without fetal macrosomia.
Copyright © 2003 by Walter de Gruyter GmbH & Co. KG
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- MRI during pregnancy
- Magnetic resonance imaging and ultrasound in the assessment of the fetal central nervous system
- Maternal erythrocyte malondialdehyde level in preeclampsia prediction: a longitudinal study
- Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes
- Association between maternal-fetal Doppler velocimetry and fetal lung maturity
- Does the thrifty phenotype result from chronic glutamate intoxication? A hypothesis
- Fetal hand movements and facial expression in normal pregnancy studied by four-dimensional sonography
- Stable microbubble test and click test to predict respiratory distress syndrome in preterm infants not requiring ventilation at birth
- Staphylococcal scalded skin syndrome in two very low birth weight infants
- Umbilical glutathione levels are higher after vaginal birth than after cesarean section
- Gastrointestinal contrast studies in high-risk neonates with suspected necrotising enterocolitis – a note of caution
- Fatal intracranial hemorrhage in a pregnant patient with autoimmune thrombocytopenic purpura
- Pregnancy complicated with pure red cell aplasia: a case report
- Mucopolysaccharidosis type VII as a cause of recurrent non-immune hydrops fetalis
- Higher risk of persistent pulmonary hypertension of the newborn after cesarean
- Congress Calendar
Articles in the same Issue
- Author Index
- Subject Index
- Contents
- MRI during pregnancy
- Magnetic resonance imaging and ultrasound in the assessment of the fetal central nervous system
- Maternal erythrocyte malondialdehyde level in preeclampsia prediction: a longitudinal study
- Effect of fetal macrosomia on human placental glucose transport and utilization in insulin-treated gestational diabetes
- Association between maternal-fetal Doppler velocimetry and fetal lung maturity
- Does the thrifty phenotype result from chronic glutamate intoxication? A hypothesis
- Fetal hand movements and facial expression in normal pregnancy studied by four-dimensional sonography
- Stable microbubble test and click test to predict respiratory distress syndrome in preterm infants not requiring ventilation at birth
- Staphylococcal scalded skin syndrome in two very low birth weight infants
- Umbilical glutathione levels are higher after vaginal birth than after cesarean section
- Gastrointestinal contrast studies in high-risk neonates with suspected necrotising enterocolitis – a note of caution
- Fatal intracranial hemorrhage in a pregnant patient with autoimmune thrombocytopenic purpura
- Pregnancy complicated with pure red cell aplasia: a case report
- Mucopolysaccharidosis type VII as a cause of recurrent non-immune hydrops fetalis
- Higher risk of persistent pulmonary hypertension of the newborn after cesarean
- Congress Calendar
